O14965: Aurora kinase A

General Information

Protein names	- Aurora kinase A - 2.7.11.1 {ECO:0000269\|PubMed:27837025} - Aurora 2 - Aurora/IPL1-related kinase 1 - ARK-1 - Aurora-related kinase 1 - hARK1 - Breast tumor-amplified kinase - Serine/threonine-protein kinase 15 - Serine/threonine-protein kinase 6 - Serine/threonine-protein kinase aurora-A
Gene names	AURKA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O14965

1 N-termini

6 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDRSKENCIS GPVKATAPVG GPKRVLVTQQ FPCQNPLPVN SGQAQRVLCP SNSSQRVPLQ
        70         80         90        100        110        120
AQKLVSSHKP VQNQKQKQLQ ATSVPHPVSR PLNNTQKSKQ PLPSAPENNP EEELASKQKN
       130        140        150        160        170        180
EESKKRQWAL EDFEIGRPLG KGKFGNVYLA REKQSKFILA LKVLFKAQLE KAGVEHQLRR
       190        200        210        220        230        240
EVEIQSHLRH PNILRLYGYF HDATRVYLIL EYAPLGTVYR ELQKLSKFDE QRTATYITEL
       250        260        270        280        290        300
ANALSYCHSK RVIHRDIKPE NLLLGSAGEL KIADFGWSVH APSSRRTTLC GTLDYLPPEM
       310        320        330        340        350        360
IEGRMHDEKV DLWSLGVLCY EFLVGKPPFE ANTYQETYKR ISRVEFTFPD FVTEGARDLI
       370        380        390        400
SRLLKHNPSQ RPMLREVLEH PWITANSSKP SNCQNKESAS KQS

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

1 N-termini - 6 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O14965-1-unknown	MDRSKE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KQKQLQ	79	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000401358
...LPSAPE	106	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000405170
...GKFGNV	146	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000405042
...IQSHLR	188	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000388073
...AGELKI	271	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000393452
...ASKQS	403	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)