TopFIND 4.0

O14975: Very long-chain acyl-CoA synthetase

General Information

Protein names
- Very long-chain acyl-CoA synthetase
- VLACS
- VLCS
- 6.2.1.-
- Fatty acid transport protein 2
- FATP-2
- Fatty-acid-coenzyme A ligase, very long-chain 1
- Long-chain-fatty-acid--CoA ligase
- 6.2.1.3
- Solute carrier family 27 member 2
- THCA-CoA ligase
- Very long-chain-fatty-acid-CoA ligase
Gene names SLC27A2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID O14975

3

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MLSAIYTVLA GLLFLPLLVN LCCPYFFQDI GYFLKVAAVG RRVRSYGKRR PARTILRAFL 
        70         80         90        100        110        120 
EKARQTPHKP FLLFRDETLT YAQVDRRSNQ VARALHDHLG LRQGDCVALL MGNEPAYVWL 
       130        140        150        160        170        180 
WLGLVKLGCA MACLNYNIRA KSLLHCFQCC GAKVLLVSPE LQAAVEEILP SLKKDDVSIY 
       190        200        210        220        230        240 
YVSRTSNTDG IDSFLDKVDE VSTEPIPESW RSEVTFSTPA LYIYTSGTTG LPKAAMITHQ 
       250        260        270        280        290        300 
RIWYGTGLTF VSGLKADDVI YITLPFYHSA ALLIGIHGCI VAGATLALRT KFSASQFWDD 
       310        320        330        340        350        360 
CRKYNVTVIQ YIGELLRYLC NSPQKPNDRD HKVRLALGNG LRGDVWRQFV KRFGDICIYE 
       370        380        390        400        410        420 
FYAATEGNIG FMNYARKVGA VGRVNYLQKK IITYDLIKYD VEKDEPVRDE NGYCVRVPKG 
       430        440        450        460        470        480 
EVGLLVCKIT QLTPFNGYAG AKAQTEKKKL RDVFKKGDLY FNSGDLLMVD HENFIYFHDR 
       490        500        510        520        530        540 
VGDTFRWKGE NVATTEVADT VGLVDFVQEV NVYGVHVPDH EGRIGMASIK MKENHEFDGK 
       550        560        570        580        590        600 
KLFQHIADYL PSYARPRFLR IQDTIEITGT FKHRKMTLVE EGFNPAVIKD ALYFLDDTAK 
       610        620    
MYVPMTEDIY NAISAKTLKL 

Isoforms

- Isoform 2 of Very long-chain acyl-CoA synthetase

Sequence View

        10         20         30         40         50         60 
MLSAIYTVLA GLLFLPLLVN LCCPYFFQDI GYFLKVAAVG RRVRSYGKRR PARTILRAFL 
        70         80         90        100        110        120 
EKARQTPHKP FLLFRDETLT YAQVDRRSNQ VARALHDHLG LRQGDCVALL MGNEPAYVWL 
       130        140        150        160        170        180 
WLGLVKLGCA MACLNYNIRA KSLLHCFQCC GAKVLLVSPE LQAAVEEILP SLKKDDVSIY 
       190        200        210        220        230        240 
YVSRTSNTDG IDSFLDKVDE VSTEPIPESW RSEVTFSTPA LYIYTSGTTG LPKAAMITHQ 
       250        260        270        280        290        300 
RIWYGTGLTF VSGLKADDVI YITLPFYHSA ALLIGIHGCI VAGATLALRT KFSASQFWDD 
       310        320        330        340        350        360 
CRKYNVTVIQ YIGELLRYLC NSPQKPNDRD HKVRLALGNG LRGDVWRQFV KRFGDICIYE 
       370        380        390        400        410        420 
FYAATEGNIG FMNYARKVGA VGRVNYLQKK IITYDLIKYD VEKDEPVRDE NGYCVRVPKG 
       430        440        450        460        470        480 
EVGLLVCKIT QLTPFNGYAG AKAQTEKKKL RDVFKKGDLY FNSGDLLMVD HENFIYFHDR 
       490        500        510        520        530        540 
VGDTFRWKGE NVATTEVADT VGLVDFVQEV NVYGVHVPDH EGRIGMASIK MKENHEFDGK 
       550        560        570        580        590        600 
KLFQHIADYL PSYARPRFLR IQDTIEITGT FKHRKMTLVE EGFNPAVIKD ALYFLDDTAK 
       610        620    
MYVPMTEDIY NAISAKTLKL 



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Protease Assignment Confidence:


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Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...KTLKL 620 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...KTLKL 620 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt84244

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)