O15091: Mitochondrial ribonuclease P catalytic subunit

General Information

Protein names	- Mitochondrial ribonuclease P catalytic subunit - 3.1.26.5 {ECO:0000269\|PubMed:25953853} - Mitochondrial ribonuclease P protein 3 {ECO:0000303\|PubMed:18984158} - Mitochondrial RNase P protein 3 {ECO:0000303\|PubMed:18984158}
Gene names	KIAA0391
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O15091

6 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Mitochondrial ribonuclease P protein 3 - Isoform 3 of Mitochondrial ribonuclease P protein 3 - Isoform 4 of Mitochondrial ribonuclease P protein 3 - Isoform 2 of Mitochondrial ribonuclease P catalytic subunit - Isoform 3 of Mitochondrial ribonuclease P catalytic subunit - Isoform 4 of Mitochondrial ribonuclease P catalytic subunit

Sequence View

        10         20         30         40         50         60
MTFYLFGIRS FPKLWKSPYL GLGPGHSYVS LFLADRCGIR NQQRLFSLKT MSPQNTKATN
        70         80         90        100        110        120
LIAKARYLRK DEGSNKQVYS VPHFFLAGAA KERSQMNSQT EDHALAPVRN TIQLPTQPLN
       130        140        150        160        170        180
SEEWDKLKED LKENTGKTSF ESWIISQMAG CHSSIDVAKS LLAWVAAKNN GIVSYDLLVK
       190        200        210        220        230        240
YLYLCVFHMQ TSEVIDVFEI MKARYKTLEP RGYSLLIRGL IHSDRWREAL LLLEDIKKVI
       250        260        270        280        290        300
TPSKKNYNDC IQGALLHQDV NTAWNLYQEL LGHDIVPMLE TLKAFFDFGK DIKDDNYSNK
       310        320        330        340        350        360
LLDILSYLRN NQLYPGESFA HSIKTWFESV PGKQWKGQFT TVRKSGQCSG CGKTIESIQL
       370        380        390        400        410        420
SPEEYECLKG KIMRDVIDGG DQYRKTTPQE LKRFENFIKS RPPFDVVIDG LNVAKMFPKV
       430        440        450        460        470        480
RESQLLLNVV SQLAKRNLRL LVLGRKHMLR RSSQWSRDEM EEVQKQASCF FADDISEDDP
       490        500        510        520        530        540
FLLYATLHSG NHCRFITRDL MRDHKACLPD AKTQRLFFKW QQGHQLAIVN RFPGSKLTFQ
       550        560        570        580
RILSYDTVVQ TTGDSWHIPY DEDLVERCSC EVPTKWLCLH QKT         10         20         30         40         50         60
MTFYLFGIRS FPKLWKSPYL GLGPGHSYVS LFLADRCGIR NQQRLFSLKT MSPQNTKATN
        70         80         90        100        110        120
LIAKARYLRK DEGSNKQVYS VPHFFLAGAA KERSQMNSQT EDHALAPVRN TIQLPTQPLN
       130        140        150        160        170        180
SEEWDKLKED LKENTGKTSF ESWIISQMAG CHSSIDVAKS LLAWVAAKNN GIVSYDLLVK
       190        200        210        220        230        240
YLYLCVFHMQ TSEVIDVFEI MKARYKTLEP RGYSLLIRGL IHSDRWREAL LLLEDIKKVI
       250        260        270        280        290        300
TPSKKNYNDC IQGALLHQDV NTAWNLYQEL LGHDIVPMLE TLKAFFDFGK DIKDDNYSNK
       310        320        330        340        350        360
LLDILSYLRN NQLYPGESFA HSIKTWFESV PGKQWKGQFT TVRKSGQCSG CGKTIESIQL
       370        380        390        400        410        420
SPEEYECLKG KIMRDVIDGG DQYRKTTPQE LKRFENFIKS RPPFDVVIDG LNVAKMFPKV
       430        440        450        460        470        480
RESQLLLNVV SQLAKRNLRL LVLGRKHMLR RSSQWSRDEM EEVQKQASCF FADDISEDDP
       490        500        510        520        530        540
FLLYATLHSG NHCRFITRDL MRDHKACLPD AKTQRLFFKW QQGHQLAIVN RFPGSKLTFQ
       550        560        570        580
RILSYDTVVQ TTGDSWHIPY DEDLVERCSC EVPTKWLCLH QKT         10         20         30         40         50         60
MTFYLFGIRS FPKLWKSPYL GLGPGHSYVS LFLADRCGIR NQQRLFSLKT MSPQNTKATN
        70         80         90        100        110        120
LIAKARYLRK DEGSNKQVYS VPHFFLAGAA KERSQMNSQT EDHALAPVRN TIQLPTQPLN
       130        140        150        160        170        180
SEEWDKLKED LKENTGKTSF ESWIISQMAG CHSSIDVAKS LLAWVAAKNN GIVSYDLLVK
       190        200        210        220        230        240
YLYLCVFHMQ TSEVIDVFEI MKARYKTLEP RGYSLLIRGL IHSDRWREAL LLLEDIKKVI
       250        260        270        280        290        300
TPSKKNYNDC IQGALLHQDV NTAWNLYQEL LGHDIVPMLE TLKAFFDFGK DIKDDNYSNK
       310        320        330        340        350        360
LLDILSYLRN NQLYPGESFA HSIKTWFESV PGKQWKGQFT TVRKSGQCSG CGKTIESIQL
       370        380        390        400        410        420
SPEEYECLKG KIMRDVIDGG DQYRKTTPQE LKRFENFIKS RPPFDVVIDG LNVAKMFPKV
       430        440        450        460        470        480
RESQLLLNVV SQLAKRNLRL LVLGRKHMLR RSSQWSRDEM EEVQKQASCF FADDISEDDP
       490        500        510        520        530        540
FLLYATLHSG NHCRFITRDL MRDHKACLPD AKTQRLFFKW QQGHQLAIVN RFPGSKLTFQ
       550        560        570        580
RILSYDTVVQ TTGDSWHIPY DEDLVERCSC EVPTKWLCLH QKT         10         20         30         40         50         60
MTFYLFGIRS FPKLWKSPYL GLGPGHSYVS LFLADRCGIR NQQRLFSLKT MSPQNTKATN
        70         80         90        100        110        120
LIAKARYLRK DEGSNKQVYS VPHFFLAGAA KERSQMNSQT EDHALAPVRN TIQLPTQPLN
       130        140        150        160        170        180
SEEWDKLKED LKENTGKTSF ESWIISQMAG CHSSIDVAKS LLAWVAAKNN GIVSYDLLVK
       190        200        210        220        230        240
YLYLCVFHMQ TSEVIDVFEI MKARYKTLEP RGYSLLIRGL IHSDRWREAL LLLEDIKKVI
       250        260        270        280        290        300
TPSKKNYNDC IQGALLHQDV NTAWNLYQEL LGHDIVPMLE TLKAFFDFGK DIKDDNYSNK
       310        320        330        340        350        360
LLDILSYLRN NQLYPGESFA HSIKTWFESV PGKQWKGQFT TVRKSGQCSG CGKTIESIQL
       370        380        390        400        410        420
SPEEYECLKG KIMRDVIDGG DQYRKTTPQE LKRFENFIKS RPPFDVVIDG LNVAKMFPKV
       430        440        450        460        470        480
RESQLLLNVV SQLAKRNLRL LVLGRKHMLR RSSQWSRDEM EEVQKQASCF FADDISEDDP
       490        500        510        520        530        540
FLLYATLHSG NHCRFITRDL MRDHKACLPD AKTQRLFFKW QQGHQLAIVN RFPGSKLTFQ
       550        560        570        580
RILSYDTVVQ TTGDSWHIPY DEDLVERCSC EVPTKWLCLH QKT         10         20         30         40         50         60
MTFYLFGIRS FPKLWKSPYL GLGPGHSYVS LFLADRCGIR NQQRLFSLKT MSPQNTKATN
        70         80         90        100        110        120
LIAKARYLRK DEGSNKQVYS VPHFFLAGAA KERSQMNSQT EDHALAPVRN TIQLPTQPLN
       130        140        150        160        170        180
SEEWDKLKED LKENTGKTSF ESWIISQMAG CHSSIDVAKS LLAWVAAKNN GIVSYDLLVK
       190        200        210        220        230        240
YLYLCVFHMQ TSEVIDVFEI MKARYKTLEP RGYSLLIRGL IHSDRWREAL LLLEDIKKVI
       250        260        270        280        290        300
TPSKKNYNDC IQGALLHQDV NTAWNLYQEL LGHDIVPMLE TLKAFFDFGK DIKDDNYSNK
       310        320        330        340        350        360
LLDILSYLRN NQLYPGESFA HSIKTWFESV PGKQWKGQFT TVRKSGQCSG CGKTIESIQL
       370        380        390        400        410        420
SPEEYECLKG KIMRDVIDGG DQYRKTTPQE LKRFENFIKS RPPFDVVIDG LNVAKMFPKV
       430        440        450        460        470        480
RESQLLLNVV SQLAKRNLRL LVLGRKHMLR RSSQWSRDEM EEVQKQASCF FADDISEDDP
       490        500        510        520        530        540
FLLYATLHSG NHCRFITRDL MRDHKACLPD AKTQRLFFKW QQGHQLAIVN RFPGSKLTFQ
       550        560        570        580
RILSYDTVVQ TTGDSWHIPY DEDLVERCSC EVPTKWLCLH QKT         10         20         30         40         50         60
MTFYLFGIRS FPKLWKSPYL GLGPGHSYVS LFLADRCGIR NQQRLFSLKT MSPQNTKATN
        70         80         90        100        110        120
LIAKARYLRK DEGSNKQVYS VPHFFLAGAA KERSQMNSQT EDHALAPVRN TIQLPTQPLN
       130        140        150        160        170        180
SEEWDKLKED LKENTGKTSF ESWIISQMAG CHSSIDVAKS LLAWVAAKNN GIVSYDLLVK
       190        200        210        220        230        240
YLYLCVFHMQ TSEVIDVFEI MKARYKTLEP RGYSLLIRGL IHSDRWREAL LLLEDIKKVI
       250        260        270        280        290        300
TPSKKNYNDC IQGALLHQDV NTAWNLYQEL LGHDIVPMLE TLKAFFDFGK DIKDDNYSNK
       310        320        330        340        350        360
LLDILSYLRN NQLYPGESFA HSIKTWFESV PGKQWKGQFT TVRKSGQCSG CGKTIESIQL
       370        380        390        400        410        420
SPEEYECLKG KIMRDVIDGG DQYRKTTPQE LKRFENFIKS RPPFDVVIDG LNVAKMFPKV
       430        440        450        460        470        480
RESQLLLNVV SQLAKRNLRL LVLGRKHMLR RSSQWSRDEM EEVQKQASCF FADDISEDDP
       490        500        510        520        530        540
FLLYATLHSG NHCRFITRDL MRDHKACLPD AKTQRLFFKW QQGHQLAIVN RFPGSKLTFQ
       550        560        570        580
RILSYDTVVQ TTGDSWHIPY DEDLVERCSC EVPTKWLCLH QKT

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O15091-1-unknown	MTFYLF...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81575
O15091-46-unknown	FSLKTM...	46	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O15091-46-unknown	FSLKTM...	46	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115550
O15091-80-	SVPHFF...	80		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O15091-80-unknown	SVPHFF...	80		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O15091-80-unknown	SVPHFF...	80	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159832
O15091-96-unknown	MNSQTE...	96	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81577
O15091-96-unknown	MNSQTE...	96	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt105321
O15091-373-unknown	MRDVID...	373	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81576
O15091-373-unknown	MRDVID...	373	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt105258
O15091-373-unknown	MRDVID...	373	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt105259

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LHQKT	583	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LHQKT	583	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77194
...LHQKT	583	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77195
...LHQKT	583	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77193

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)