O15105: Mothers against decapentaplegic homolog 7

General Information

Protein names	- Mothers against decapentaplegic homolog 7 - MAD homolog 7 - Mothers against DPP homolog 7 - Mothers against decapentaplegic homolog 8 - MAD homolog 8 - Mothers against DPP homolog 8 - SMAD family member 7 - SMAD 7 - Smad7 - hSMAD7
Gene names	SMAD7
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O15105

4 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Mothers against decapentaplegic homolog 7 - Isoform 3 of Mothers against decapentaplegic homolog 7

Sequence View

        10         20         30         40         50         60
MFRTKRSALV RRLWRSRAPG GEDEEEGAGG GGGGGELRGE GATDSRAHGA GGGGPGRAGC
        70         80         90        100        110        120
CLGKAVRGAK GHHHPHPPAA GAGAAGGAEA DLKALTHSVL KKLKERQLEL LLQAVESRGG
       130        140        150        160        170        180
TRTACLLLPG RLDCRLGPGA PAGAQPAQPP SSYSLPLLLC KVFRWPDLRH SSEVKRLCCC
       190        200        210        220        230        240
ESYGKINPEL VCCNPHHLSR LCELESPPPP YSRYPMDFLK PTADCPDAVP SSAETGGTNY
       250        260        270        280        290        300
LAPGGLSDSQ LLLEPGDRSH WCVVAYWEEK TRVGRLYCVQ EPSLDIFYDL PQGNGFCLGQ
       310        320        330        340        350        360
LNSDNKSQLV QKVRSKIGCG IQLTREVDGV WVYNRSSYPI FIKSATLDNP DSRTLLVHKV
       370        380        390        400        410        420
FPGFSIKAFD YEKAYSLQRP NDHEFMQQPW TGFTVQISFV KGWGQCYTRQ FISSCPCWLE

VIFNSR         10         20         30         40         50         60
MFRTKRSALV RRLWRSRAPG GEDEEEGAGG GGGGGELRGE GATDSRAHGA GGGGPGRAGC
        70         80         90        100        110        120
CLGKAVRGAK GHHHPHPPAA GAGAAGGAEA DLKALTHSVL KKLKERQLEL LLQAVESRGG
       130        140        150        160        170        180
TRTACLLLPG RLDCRLGPGA PAGAQPAQPP SSYSLPLLLC KVFRWPDLRH SSEVKRLCCC
       190        200        210        220        230        240
ESYGKINPEL VCCNPHHLSR LCELESPPPP YSRYPMDFLK PTADCPDAVP SSAETGGTNY
       250        260        270        280        290        300
LAPGGLSDSQ LLLEPGDRSH WCVVAYWEEK TRVGRLYCVQ EPSLDIFYDL PQGNGFCLGQ
       310        320        330        340        350        360
LNSDNKSQLV QKVRSKIGCG IQLTREVDGV WVYNRSSYPI FIKSATLDNP DSRTLLVHKV
       370        380        390        400        410        420
FPGFSIKAFD YEKAYSLQRP NDHEFMQQPW TGFTVQISFV KGWGQCYTRQ FISSCPCWLE

VIFNSR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O15105-1-unknown	MFRTKR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O15105-1-unknown	MFRTKR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt89984
O15105-216-unknown	MDFLKP...	216	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt89983
O15105-228-	AVPSSA...	228		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O15105-228-unknown	AVPSSA...	228	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176447
O15105-228-unknown	AVPSSA...	228	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176446

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IFNSR	426	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...IFNSR	426	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85601
...IFNSR	426	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85602

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)