O15151: Protein Mdm4

General Information

Protein names	- Protein Mdm4 - Double minute 4 protein - Mdm2-like p53-binding protein - Protein Mdmx - p53-binding protein Mdm4
Gene names	MDM4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O15151

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Protein Mdm4 - Isoform 3 of Protein Mdm4 - Isoform HDMX211 of Protein Mdm4 - Isoform 5 of Protein Mdm4

Sequence View

        10         20         30         40         50         60
MTSFSTSAQC STSDSACRIS PGQINQVRPK LPLLKILHAA GAQGEMFTVK EVMHYLGQYI
        70         80         90        100        110        120
MVKQLYDQQE QHMVYCGGDL LGELLGRQSF SVKDPSPLYD MLRKNLVTLA TATTDAAQTL
       130        140        150        160        170        180
ALAQDHSMDI PSQDQLKQSA EESSTSRKRT TEDDIPTLPT SEHKCIHSRE DEDLIENLAQ
       190        200        210        220        230        240
DETSRLDLGF EEWDVAGLPW WFLGNLRSNY TPRSNGSTDL QTNQDVGTAI VSDTTDDLWF
       250        260        270        280        290        300
LNESVSEQLG VGIKVEAADT EQTSEEVGKV SDKKVIEVGK NDDLEDSKSL SDDTDVEVTS
       310        320        330        340        350        360
EDEWQCTECK KFNSPSKRYC FRCWALRKDW YSDCSKLTHS LSTSDITAIP EKENEGNDVP
       370        380        390        400        410        420
DCRRTISAPV VRPKDAYIKK ENSKLFDPCN SVEFLDLAHS SESQETISSM GEQLDNLSEQ
       430        440        450        460        470        480
RTDTENMEDC QNLLKPCSLC EKRPRDGNII HGRTGHLVTC FHCARRLKKA GASCPICKKE
       490
IQLVIKVFIA         10         20         30         40         50         60
MTSFSTSAQC STSDSACRIS PGQINQVRPK LPLLKILHAA GAQGEMFTVK EVMHYLGQYI
        70         80         90        100        110        120
MVKQLYDQQE QHMVYCGGDL LGELLGRQSF SVKDPSPLYD MLRKNLVTLA TATTDAAQTL
       130        140        150        160        170        180
ALAQDHSMDI PSQDQLKQSA EESSTSRKRT TEDDIPTLPT SEHKCIHSRE DEDLIENLAQ
       190        200        210        220        230        240
DETSRLDLGF EEWDVAGLPW WFLGNLRSNY TPRSNGSTDL QTNQDVGTAI VSDTTDDLWF
       250        260        270        280        290        300
LNESVSEQLG VGIKVEAADT EQTSEEVGKV SDKKVIEVGK NDDLEDSKSL SDDTDVEVTS
       310        320        330        340        350        360
EDEWQCTECK KFNSPSKRYC FRCWALRKDW YSDCSKLTHS LSTSDITAIP EKENEGNDVP
       370        380        390        400        410        420
DCRRTISAPV VRPKDAYIKK ENSKLFDPCN SVEFLDLAHS SESQETISSM GEQLDNLSEQ
       430        440        450        460        470        480
RTDTENMEDC QNLLKPCSLC EKRPRDGNII HGRTGHLVTC FHCARRLKKA GASCPICKKE
       490
IQLVIKVFIA         10         20         30         40         50         60
MTSFSTSAQC STSDSACRIS PGQINQVRPK LPLLKILHAA GAQGEMFTVK EVMHYLGQYI
        70         80         90        100        110        120
MVKQLYDQQE QHMVYCGGDL LGELLGRQSF SVKDPSPLYD MLRKNLVTLA TATTDAAQTL
       130        140        150        160        170        180
ALAQDHSMDI PSQDQLKQSA EESSTSRKRT TEDDIPTLPT SEHKCIHSRE DEDLIENLAQ
       190        200        210        220        230        240
DETSRLDLGF EEWDVAGLPW WFLGNLRSNY TPRSNGSTDL QTNQDVGTAI VSDTTDDLWF
       250        260        270        280        290        300
LNESVSEQLG VGIKVEAADT EQTSEEVGKV SDKKVIEVGK NDDLEDSKSL SDDTDVEVTS
       310        320        330        340        350        360
EDEWQCTECK KFNSPSKRYC FRCWALRKDW YSDCSKLTHS LSTSDITAIP EKENEGNDVP
       370        380        390        400        410        420
DCRRTISAPV VRPKDAYIKK ENSKLFDPCN SVEFLDLAHS SESQETISSM GEQLDNLSEQ
       430        440        450        460        470        480
RTDTENMEDC QNLLKPCSLC EKRPRDGNII HGRTGHLVTC FHCARRLKKA GASCPICKKE
       490
IQLVIKVFIA         10         20         30         40         50         60
MTSFSTSAQC STSDSACRIS PGQINQVRPK LPLLKILHAA GAQGEMFTVK EVMHYLGQYI
        70         80         90        100        110        120
MVKQLYDQQE QHMVYCGGDL LGELLGRQSF SVKDPSPLYD MLRKNLVTLA TATTDAAQTL
       130        140        150        160        170        180
ALAQDHSMDI PSQDQLKQSA EESSTSRKRT TEDDIPTLPT SEHKCIHSRE DEDLIENLAQ
       190        200        210        220        230        240
DETSRLDLGF EEWDVAGLPW WFLGNLRSNY TPRSNGSTDL QTNQDVGTAI VSDTTDDLWF
       250        260        270        280        290        300
LNESVSEQLG VGIKVEAADT EQTSEEVGKV SDKKVIEVGK NDDLEDSKSL SDDTDVEVTS
       310        320        330        340        350        360
EDEWQCTECK KFNSPSKRYC FRCWALRKDW YSDCSKLTHS LSTSDITAIP EKENEGNDVP
       370        380        390        400        410        420
DCRRTISAPV VRPKDAYIKK ENSKLFDPCN SVEFLDLAHS SESQETISSM GEQLDNLSEQ
       430        440        450        460        470        480
RTDTENMEDC QNLLKPCSLC EKRPRDGNII HGRTGHLVTC FHCARRLKKA GASCPICKKE
       490
IQLVIKVFIA

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O15151-1-unknown	MTSFST...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O15151-1-unknown	MTSFST...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80734
O15151-1-unknown	MTSFST...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80735
O15151-1-unknown	MTSFST...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80736
O15151-1-unknown	MTSFST...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80737
O15151-2-acetylation	TSFSTS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O15151-2-acetylation	TSFSTS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162882
O15151-2-acetylation	TSFSTS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162883
O15151-2-acetylation	TSFSTS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162884
O15151-2-acetylation	TSFSTS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162885
O15151-362-unknown	CRRTIS...	362		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1399
O15151-362-unknown	CRRTIS...	362		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150159
O15151-362-unknown	CRRTIS...	362		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198926

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NDVPDC	361	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1399
...NDVPDC	361	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133552
...KVFIA	490	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KVFIA	490	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76354
...KVFIA	490	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76355

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	361	VPDC.\|.CRRT	inferred from experiment	unknown	MEROPS	Moretti F	Gentiletti F et al.:MDMX stability is regulated by ... (C14.003)	11840332,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)