TopFIND 4.0

O15229: Kynurenine 3-monooxygenase {ECO:0000255|HAMAP-Rule:MF_03018}

General Information

Protein names
- Kynurenine 3-monooxygenase {ECO:0000255|HAMAP-Rule:MF_03018}
- 1.14.13.9 {ECO:0000255|HAMAP-Rule:MF_03018}
- Kynurenine 3-hydroxylase {ECO:0000255|HAMAP-Rule:MF_03018}
Gene names KMO
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID O15229

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MDSSVIQRKK VAVIGGGLVG SLQACFLAKR NFQIDVYEAR EDTRVATFTR GRSINLALSH 
        70         80         90        100        110        120 
RGRQALKAVG LEDQIVSQGI PMRARMIHSL SGKKSAIPYG TKSQYILSVS RENLNKDLLT 
       130        140        150        160        170        180 
AAEKYPNVKM HFNHRLLKCN PEEGMITVLG SDKVPKDVTC DLIVGCDGAY STVRSHLMKK 
       190        200        210        220        230        240 
PRFDYSQQYI PHGYMELTIP PKNGDYAMEP NYLHIWPRNT FMMIALPNMN KSFTCTLFMP 
       250        260        270        280        290        300 
FEEFEKLLTS NDVVDFFQKY FPDAIPLIGE KLLVQDFFLL PAQPMISVKC SSFHFKSHCV 
       310        320        330        340        350        360 
LLGDAAHAIV PFFGQGMNAG FEDCLVFDEL MDKFSNDLSL CLPVFSRLRI PDDHAISDLS 
       370        380        390        400        410        420 
MYNYIEMRAH VNSSWFIFQK NMERFLHAIM PSTFIPLYTM VTFSRIRYHE AVQRWHWQKK 
       430        440        450        460        470        480 
VINKGLFFLG SLIAISSTYL LIHYMSPRSF LRLRRPWNWI AHFRNTTCFP AKAVDSLEQI 
   
SNLISR

Isoforms

- Isoform 2 of Kynurenine 3-monooxygenase - Isoform 3 of Kynurenine 3-monooxygenase

Sequence View

        10         20         30         40         50         60 
MDSSVIQRKK VAVIGGGLVG SLQACFLAKR NFQIDVYEAR EDTRVATFTR GRSINLALSH 
        70         80         90        100        110        120 
RGRQALKAVG LEDQIVSQGI PMRARMIHSL SGKKSAIPYG TKSQYILSVS RENLNKDLLT 
       130        140        150        160        170        180 
AAEKYPNVKM HFNHRLLKCN PEEGMITVLG SDKVPKDVTC DLIVGCDGAY STVRSHLMKK 
       190        200        210        220        230        240 
PRFDYSQQYI PHGYMELTIP PKNGDYAMEP NYLHIWPRNT FMMIALPNMN KSFTCTLFMP 
       250        260        270        280        290        300 
FEEFEKLLTS NDVVDFFQKY FPDAIPLIGE KLLVQDFFLL PAQPMISVKC SSFHFKSHCV 
       310        320        330        340        350        360 
LLGDAAHAIV PFFGQGMNAG FEDCLVFDEL MDKFSNDLSL CLPVFSRLRI PDDHAISDLS 
       370        380        390        400        410        420 
MYNYIEMRAH VNSSWFIFQK NMERFLHAIM PSTFIPLYTM VTFSRIRYHE AVQRWHWQKK 
       430        440        450        460        470        480 
VINKGLFFLG SLIAISSTYL LIHYMSPRSF LRLRRPWNWI AHFRNTTCFP AKAVDSLEQI 
   
SNLISR         10         20         30         40         50         60 
MDSSVIQRKK VAVIGGGLVG SLQACFLAKR NFQIDVYEAR EDTRVATFTR GRSINLALSH 
        70         80         90        100        110        120 
RGRQALKAVG LEDQIVSQGI PMRARMIHSL SGKKSAIPYG TKSQYILSVS RENLNKDLLT 
       130        140        150        160        170        180 
AAEKYPNVKM HFNHRLLKCN PEEGMITVLG SDKVPKDVTC DLIVGCDGAY STVRSHLMKK 
       190        200        210        220        230        240 
PRFDYSQQYI PHGYMELTIP PKNGDYAMEP NYLHIWPRNT FMMIALPNMN KSFTCTLFMP 
       250        260        270        280        290        300 
FEEFEKLLTS NDVVDFFQKY FPDAIPLIGE KLLVQDFFLL PAQPMISVKC SSFHFKSHCV 
       310        320        330        340        350        360 
LLGDAAHAIV PFFGQGMNAG FEDCLVFDEL MDKFSNDLSL CLPVFSRLRI PDDHAISDLS 
       370        380        390        400        410        420 
MYNYIEMRAH VNSSWFIFQK NMERFLHAIM PSTFIPLYTM VTFSRIRYHE AVQRWHWQKK 
       430        440        450        460        470        480 
VINKGLFFLG SLIAISSTYL LIHYMSPRSF LRLRRPWNWI AHFRNTTCFP AKAVDSLEQI 
   
SNLISR



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    O15229-1-unknown MDSSVI... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    O15229-1-unknown MDSSVI... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt79174
    O15229-1-unknown MDSSVI... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt79175

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)