O15265: Ataxin-7

General Information

Protein names	- Ataxin-7 - Spinocerebellar ataxia type 7 protein
Gene names	ATXN7
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O15265

3 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform b of Ataxin-7 - Isoform 3 of Ataxin-7

Sequence View

        10         20         30         40         50         60
MSERAADDVR GEPRRAAAAA GGAAAAAARQ QQQQQQQQQP PPPQPQRQQH PPPPPRRTRP
        70         80         90        100        110        120
EDGGPGAAST SAAAMATVGE RRPLPSPEVM LGQSWNLWVE ASKLPGKDGT ELDESFKEFG
       130        140        150        160        170        180
KNREVMGLCR EDMPIFGFCP AHDDFYLVVC NDCNQVVKPQ AFQSHYERRH SSSSKPPLAV
       190        200        210        220        230        240
PPTSVFSFFP SLSKSKGGSA SGSNRSSSGG VLSASSSSSK LLKSPKEKLQ LRGNTRPMHP
       250        260        270        280        290        300
IQQSRVPHGR IMTPSVKVEK IHPKMDGTLL KSAVGPTCPA TVSSLVKPGL NCPSIPKPTL
       310        320        330        340        350        360
PSPGQILNGK GLPAPPTLEK KPEDNSNNRK FLNKRLSERE FDPDIHCGVI DLDTKKPCTR
       370        380        390        400        410        420
SLTCKTHSLT QRRAVQGRRK RFDVLLAEHK NKTREKELIR HPDSQQPPQP LRDPHPAPPR
       430        440        450        460        470        480
TSQEPHQNPH GVIPSESKPF VASKPKPHTP SLPRPPGCPA QQGGSAPIDP PPVHESPHPP
       490        500        510        520        530        540
LPATEPASRL SSEEGEGDDK EESVEKLDCH YSGHHPQPAS FCTFGSRQIG RGYYVFDSRW
       550        560        570        580        590        600
NRLRCALNLM VEKHLNAQLW KKIPPVPSTT SPISTRIPHR TNSVPTSQCG VSYLAAATVS
       610        620        630        640        650        660
TSPVLLSSTC ISPNSKSVPA HGTTLNAQPA ASGAMDPVCS MQSRQVSSSS SSPSTPSGLS
       670        680        690        700        710        720
SVPSSPMSRK PQKLKSSKSL RPKESSGNST NCQNASSSTS GGSGKKRKNS SPLLVHSSSS
       730        740        750        760        770        780
SSSSSSSSHS MESFRKNCVA HSGPPYPSTV TSSHSIGLNC VTNKANAVNV RHDQSGRGPP
       790        800        810        820        830        840
TGSPAESIKR MSVMVNSSDS TLSLGPFIHQ SNELPVNSHG SFSHSHTPLD KLIGKKRKCS
       850        860        870        880        890
PSSSSINNSS SKPTKVAKVP AVNNVHMKHT GTIPGAQGLM NSSLLHQPKA RP         10         20         30         40         50         60
MSERAADDVR GEPRRAAAAA GGAAAAAARQ QQQQQQQQQP PPPQPQRQQH PPPPPRRTRP
        70         80         90        100        110        120
EDGGPGAAST SAAAMATVGE RRPLPSPEVM LGQSWNLWVE ASKLPGKDGT ELDESFKEFG
       130        140        150        160        170        180
KNREVMGLCR EDMPIFGFCP AHDDFYLVVC NDCNQVVKPQ AFQSHYERRH SSSSKPPLAV
       190        200        210        220        230        240
PPTSVFSFFP SLSKSKGGSA SGSNRSSSGG VLSASSSSSK LLKSPKEKLQ LRGNTRPMHP
       250        260        270        280        290        300
IQQSRVPHGR IMTPSVKVEK IHPKMDGTLL KSAVGPTCPA TVSSLVKPGL NCPSIPKPTL
       310        320        330        340        350        360
PSPGQILNGK GLPAPPTLEK KPEDNSNNRK FLNKRLSERE FDPDIHCGVI DLDTKKPCTR
       370        380        390        400        410        420
SLTCKTHSLT QRRAVQGRRK RFDVLLAEHK NKTREKELIR HPDSQQPPQP LRDPHPAPPR
       430        440        450        460        470        480
TSQEPHQNPH GVIPSESKPF VASKPKPHTP SLPRPPGCPA QQGGSAPIDP PPVHESPHPP
       490        500        510        520        530        540
LPATEPASRL SSEEGEGDDK EESVEKLDCH YSGHHPQPAS FCTFGSRQIG RGYYVFDSRW
       550        560        570        580        590        600
NRLRCALNLM VEKHLNAQLW KKIPPVPSTT SPISTRIPHR TNSVPTSQCG VSYLAAATVS
       610        620        630        640        650        660
TSPVLLSSTC ISPNSKSVPA HGTTLNAQPA ASGAMDPVCS MQSRQVSSSS SSPSTPSGLS
       670        680        690        700        710        720
SVPSSPMSRK PQKLKSSKSL RPKESSGNST NCQNASSSTS GGSGKKRKNS SPLLVHSSSS
       730        740        750        760        770        780
SSSSSSSSHS MESFRKNCVA HSGPPYPSTV TSSHSIGLNC VTNKANAVNV RHDQSGRGPP
       790        800        810        820        830        840
TGSPAESIKR MSVMVNSSDS TLSLGPFIHQ SNELPVNSHG SFSHSHTPLD KLIGKKRKCS
       850        860        870        880        890
PSSSSINNSS SKPTKVAKVP AVNNVHMKHT GTIPGAQGLM NSSLLHQPKA RP

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O15265-1-unknown	MSERAA...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O15265-1-unknown	MSERAA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt68012
O15265-267-unknown	GTLLKS...	267	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2770
O15265-267-unknown	GTLLKS...	267	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143574
O15265-267-unknown	GTLLKS...	267	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149061
O15265-345-unknown	IHCGVI...	345	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2773
O15265-345-unknown	IHCGVI...	345	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146578
O15265-345-unknown	IHCGVI...	345	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150853

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HPKMDG	266	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2770
...HPKMDG	266	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126816
...HPKMDG	266	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132445
...EFDPDI	344	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2773
...EFDPDI	344	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129885
...EFDPDI	344	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134254
...PKARP	892	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PKARP	892	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63631

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP7_HUMAN	266	KMDG.\|.GTLL	inferred from experiment	unknown	MEROPS	Ellerby LM	Young JE et al.:Proteolytic cleavage of ataxin-... (C14.004)	17646170,
CASP7_HUMAN	344	DPDI.\|.IHCG	inferred from experiment	unknown	MEROPS	Ellerby LM	Young JE et al.:Proteolytic cleavage of ataxin-... (C14.004)	17646170,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)