TopFIND 4.0

O15344: E3 ubiquitin-protein ligase Midline-1

General Information

Protein names
- E3 ubiquitin-protein ligase Midline-1
- 2.3.2.27
- Midin
- Putative transcription factor XPRF
- RING finger protein 59
- RING finger protein Midline-1
- RING-type E3 ubiquitin transferase Midline-1 {ECO:0000305}
- Tripartite motif-containing protein 18
Gene names MID1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID O15344

1

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
METLESELTC PICLELFEDP LLLPCAHSLC FNCAHRILVS HCATNESVES ITAFQCPTCR 
        70         80         90        100        110        120 
HVITLSQRGL DGLKRNVTLQ NIIDRFQKAS VSGPNSPSET RRERAFDANT MTSAEKVLCQ 
       130        140        150        160        170        180 
FCDQDPAQDA VKTCVTCEVS YCDECLKATH PNKKPFTGHR LIEPIPDSHI RGLMCLEHED 
       190        200        210        220        230        240 
EKVNMYCVTD DQLICALCKL VGRHRDHQVA ALSERYDKLK QNLESNLTNL IKRNTELETL 
       250        260        270        280        290        300 
LAKLIQTCQH VEVNASRQEA KLTEECDLLI EIIQQRRQII GTKIKEGKVM RLRKLAQQIA 
       310        320        330        340        350        360 
NCKQCIERSA SLISQAEHSL KENDHARFLQ TAKNITERVS MATASSQVLI PEINLNDTFD 
       370        380        390        400        410        420 
TFALDFSREK KLLECLDYLT APNPPTIREE LCTASYDTIT VHWTSDDEFS VVSYELQYTI 
       430        440        450        460        470        480 
FTGQANVVSL CNSADSWMIV PNIKQNHYTV HGLQSGTKYI FMVKAINQAG SRSSEPGKLK 
       490        500        510        520        530        540 
TNSQPFKLDP KSAHRKLKVS HDNLTVERDE SSSKKSHTPE RFTSQGSYGV AGNVFIDSGR 
       550        560        570        580        590        600 
HYWEVVISGS TWYAIGLAYK SAPKHEWIGK NSASWALCRC NNNWVVRHNS KEIPIEPAPH 
       610        620        630        640        650        660 
LRRVGILLDY DNGSIAFYDA LNSIHLYTFD VAFAQPVCPT FTVWNKCLTI ITGLPIPDHL 
   
DCTEQLP

Isoforms

- Isoform 2 of E3 ubiquitin-protein ligase Midline-1

Sequence View

        10         20         30         40         50         60 
METLESELTC PICLELFEDP LLLPCAHSLC FNCAHRILVS HCATNESVES ITAFQCPTCR 
        70         80         90        100        110        120 
HVITLSQRGL DGLKRNVTLQ NIIDRFQKAS VSGPNSPSET RRERAFDANT MTSAEKVLCQ 
       130        140        150        160        170        180 
FCDQDPAQDA VKTCVTCEVS YCDECLKATH PNKKPFTGHR LIEPIPDSHI RGLMCLEHED 
       190        200        210        220        230        240 
EKVNMYCVTD DQLICALCKL VGRHRDHQVA ALSERYDKLK QNLESNLTNL IKRNTELETL 
       250        260        270        280        290        300 
LAKLIQTCQH VEVNASRQEA KLTEECDLLI EIIQQRRQII GTKIKEGKVM RLRKLAQQIA 
       310        320        330        340        350        360 
NCKQCIERSA SLISQAEHSL KENDHARFLQ TAKNITERVS MATASSQVLI PEINLNDTFD 
       370        380        390        400        410        420 
TFALDFSREK KLLECLDYLT APNPPTIREE LCTASYDTIT VHWTSDDEFS VVSYELQYTI 
       430        440        450        460        470        480 
FTGQANVVSL CNSADSWMIV PNIKQNHYTV HGLQSGTKYI FMVKAINQAG SRSSEPGKLK 
       490        500        510        520        530        540 
TNSQPFKLDP KSAHRKLKVS HDNLTVERDE SSSKKSHTPE RFTSQGSYGV AGNVFIDSGR 
       550        560        570        580        590        600 
HYWEVVISGS TWYAIGLAYK SAPKHEWIGK NSASWALCRC NNNWVVRHNS KEIPIEPAPH 
       610        620        630        640        650        660 
LRRVGILLDY DNGSIAFYDA LNSIHLYTFD VAFAQPVCPT FTVWNKCLTI ITGLPIPDHL 
   
DCTEQLP



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Protein Neighborhood

Domains & Features

1 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    O15344-1-unknown METLES... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    O15344-1-unknown METLES... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt93001

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...SGSTWY 552 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt88619
    ...TEQLP 667 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)