O15350: Tumor protein p73

General Information

Protein names	- Tumor protein p73 - p53-like transcription factor - p53-related protein
Gene names	TP73
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O15350

2 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform Beta of Tumor protein p73 - Isoform Gamma of Tumor protein p73 - Isoform Delta of Tumor protein p73 - Isoform Epsilon of Tumor protein p73 - Isoform Zeta of Tumor protein p73 - Isoform dN-Alpha of Tumor protein p73 - Isoform dN-Beta of Tumor protein p73 - Isoform dN-Gamma of Tumor protein p73 - Isoform 10 of Tumor protein p73 - Isoform 11 of Tumor protein p73 - Isoform 12 of Tumor protein p73

Sequence View

        10         20         30         40         50         60
MAQSTATSPD GGTTFEHLWS SLEPDSTYFD LPQSSRGNNE VVGGTDSSMD VFHLEGMTTS
        70         80         90        100        110        120
VMAQFNLLSS TMDQMSSRAA SASPYTPEHA ASVPTHSPYA QPSSTFDTMS PAPVIPSNTD
       130        140        150        160        170        180
YPGPHHFEVT FQQSSTAKSA TWTYSPLLKK LYCQIAKTCP IQIKVSTPPP PGTAIRAMPV
       190        200        210        220        230        240
YKKAEHVTDV VKRCPNHELG RDFNEGQSAP ASHLIRVEGN NLSQYVDDPV TGRQSVVVPY
       250        260        270        280        290        300
EPPQVGTEFT TILYNFMCNS SCVGGMNRRP ILIIITLEMR DGQVLGRRSF EGRICACPGR
       310        320        330        340        350        360
DRKADEDHYR EQQALNESSA KNGAASKRAF KQSPPAVPAL GAGVKKRRHG DEDTYYLQVR
       370        380        390        400        410        420
GRENFEILMK LKESLELMEL VPQPLVDSYR QQQQLLQRPS HLQPPSYGPV LSPMNKVHGG
       430        440        450        460        470        480
MNKLPSVNQL VGQPPPHSSA ATPNLGPVGP GMLNNHGHAV PANGEMSSSH SAQSMVSGSH
       490        500        510        520        530        540
CTPPPPYHAD PSLVSFLTGL GCPNCIEYFT SQGLQSIYHL QNLTIEDLGA LKIPEQYRMT
       550        560        570        580        590        600
IWRGLQDLKQ GHDYSTAQQL LRSSNAATIS IGGSGELQRQ RVMEAVHFRV RHTITIPNRG
       610        620        630
GPGGGPDEWA DFGFDLPDCK ARKQPIKEEF TEAEIH         10         20         30         40         50         60
MAQSTATSPD GGTTFEHLWS SLEPDSTYFD LPQSSRGNNE VVGGTDSSMD VFHLEGMTTS
        70         80         90        100        110        120
VMAQFNLLSS TMDQMSSRAA SASPYTPEHA ASVPTHSPYA QPSSTFDTMS PAPVIPSNTD
       130        140        150        160        170        180
YPGPHHFEVT FQQSSTAKSA TWTYSPLLKK LYCQIAKTCP IQIKVSTPPP PGTAIRAMPV
       190        200        210        220        230        240
YKKAEHVTDV VKRCPNHELG RDFNEGQSAP ASHLIRVEGN NLSQYVDDPV TGRQSVVVPY
       250        260        270        280        290        300
EPPQVGTEFT TILYNFMCNS SCVGGMNRRP ILIIITLEMR DGQVLGRRSF EGRICACPGR
       310        320        330        340        350        360
DRKADEDHYR EQQALNESSA KNGAASKRAF KQSPPAVPAL GAGVKKRRHG DEDTYYLQVR
       370        380        390        400        410        420
GRENFEILMK LKESLELMEL VPQPLVDSYR QQQQLLQRPS HLQPPSYGPV LSPMNKVHGG
       430        440        450        460        470        480
MNKLPSVNQL VGQPPPHSSA ATPNLGPVGP GMLNNHGHAV PANGEMSSSH SAQSMVSGSH
       490        500        510        520        530        540
CTPPPPYHAD PSLVSFLTGL GCPNCIEYFT SQGLQSIYHL QNLTIEDLGA LKIPEQYRMT
       550        560        570        580        590        600
IWRGLQDLKQ GHDYSTAQQL LRSSNAATIS IGGSGELQRQ RVMEAVHFRV RHTITIPNRG
       610        620        630
GPGGGPDEWA DFGFDLPDCK ARKQPIKEEF TEAEIH         10         20         30         40         50         60
MAQSTATSPD GGTTFEHLWS SLEPDSTYFD LPQSSRGNNE VVGGTDSSMD VFHLEGMTTS
        70         80         90        100        110        120
VMAQFNLLSS TMDQMSSRAA SASPYTPEHA ASVPTHSPYA QPSSTFDTMS PAPVIPSNTD
       130        140        150        160        170        180
YPGPHHFEVT FQQSSTAKSA TWTYSPLLKK LYCQIAKTCP IQIKVSTPPP PGTAIRAMPV
       190        200        210        220        230        240
YKKAEHVTDV VKRCPNHELG RDFNEGQSAP ASHLIRVEGN NLSQYVDDPV TGRQSVVVPY
       250        260        270        280        290        300
EPPQVGTEFT TILYNFMCNS SCVGGMNRRP ILIIITLEMR DGQVLGRRSF EGRICACPGR
       310        320        330        340        350        360
DRKADEDHYR EQQALNESSA KNGAASKRAF KQSPPAVPAL GAGVKKRRHG DEDTYYLQVR
       370        380        390        400        410        420
GRENFEILMK LKESLELMEL VPQPLVDSYR QQQQLLQRPS HLQPPSYGPV LSPMNKVHGG
       430        440        450        460        470        480
MNKLPSVNQL VGQPPPHSSA ATPNLGPVGP GMLNNHGHAV PANGEMSSSH SAQSMVSGSH
       490        500        510        520        530        540
CTPPPPYHAD PSLVSFLTGL GCPNCIEYFT SQGLQSIYHL QNLTIEDLGA LKIPEQYRMT
       550        560        570        580        590        600
IWRGLQDLKQ GHDYSTAQQL LRSSNAATIS IGGSGELQRQ RVMEAVHFRV RHTITIPNRG
       610        620        630
GPGGGPDEWA DFGFDLPDCK ARKQPIKEEF TEAEIH         10         20         30         40         50         60
MAQSTATSPD GGTTFEHLWS SLEPDSTYFD LPQSSRGNNE VVGGTDSSMD VFHLEGMTTS
        70         80         90        100        110        120
VMAQFNLLSS TMDQMSSRAA SASPYTPEHA ASVPTHSPYA QPSSTFDTMS PAPVIPSNTD
       130        140        150        160        170        180
YPGPHHFEVT FQQSSTAKSA TWTYSPLLKK LYCQIAKTCP IQIKVSTPPP PGTAIRAMPV
       190        200        210        220        230        240
YKKAEHVTDV VKRCPNHELG RDFNEGQSAP ASHLIRVEGN NLSQYVDDPV TGRQSVVVPY
       250        260        270        280        290        300
EPPQVGTEFT TILYNFMCNS SCVGGMNRRP ILIIITLEMR DGQVLGRRSF EGRICACPGR
       310        320        330        340        350        360
DRKADEDHYR EQQALNESSA KNGAASKRAF KQSPPAVPAL GAGVKKRRHG DEDTYYLQVR
       370        380        390        400        410        420
GRENFEILMK LKESLELMEL VPQPLVDSYR QQQQLLQRPS HLQPPSYGPV LSPMNKVHGG
       430        440        450        460        470        480
MNKLPSVNQL VGQPPPHSSA ATPNLGPVGP GMLNNHGHAV PANGEMSSSH SAQSMVSGSH
       490        500        510        520        530        540
CTPPPPYHAD PSLVSFLTGL GCPNCIEYFT SQGLQSIYHL QNLTIEDLGA LKIPEQYRMT
       550        560        570        580        590        600
IWRGLQDLKQ GHDYSTAQQL LRSSNAATIS IGGSGELQRQ RVMEAVHFRV RHTITIPNRG
       610        620        630
GPGGGPDEWA DFGFDLPDCK ARKQPIKEEF TEAEIH         10         20         30         40         50         60
MAQSTATSPD GGTTFEHLWS SLEPDSTYFD LPQSSRGNNE VVGGTDSSMD VFHLEGMTTS
        70         80         90        100        110        120
VMAQFNLLSS TMDQMSSRAA SASPYTPEHA ASVPTHSPYA QPSSTFDTMS PAPVIPSNTD
       130        140        150        160        170        180
YPGPHHFEVT FQQSSTAKSA TWTYSPLLKK LYCQIAKTCP IQIKVSTPPP PGTAIRAMPV
       190        200        210        220        230        240
YKKAEHVTDV VKRCPNHELG RDFNEGQSAP ASHLIRVEGN NLSQYVDDPV TGRQSVVVPY
       250        260        270        280        290        300
EPPQVGTEFT TILYNFMCNS SCVGGMNRRP ILIIITLEMR DGQVLGRRSF EGRICACPGR
       310        320        330        340        350        360
DRKADEDHYR EQQALNESSA KNGAASKRAF KQSPPAVPAL GAGVKKRRHG DEDTYYLQVR
       370        380        390        400        410        420
GRENFEILMK LKESLELMEL VPQPLVDSYR QQQQLLQRPS HLQPPSYGPV LSPMNKVHGG
       430        440        450        460        470        480
MNKLPSVNQL VGQPPPHSSA ATPNLGPVGP GMLNNHGHAV PANGEMSSSH SAQSMVSGSH
       490        500        510        520        530        540
CTPPPPYHAD PSLVSFLTGL GCPNCIEYFT SQGLQSIYHL QNLTIEDLGA LKIPEQYRMT
       550        560        570        580        590        600
IWRGLQDLKQ GHDYSTAQQL LRSSNAATIS IGGSGELQRQ RVMEAVHFRV RHTITIPNRG
       610        620        630
GPGGGPDEWA DFGFDLPDCK ARKQPIKEEF TEAEIH         10         20         30         40         50         60
MAQSTATSPD GGTTFEHLWS SLEPDSTYFD LPQSSRGNNE VVGGTDSSMD VFHLEGMTTS
        70         80         90        100        110        120
VMAQFNLLSS TMDQMSSRAA SASPYTPEHA ASVPTHSPYA QPSSTFDTMS PAPVIPSNTD
       130        140        150        160        170        180
YPGPHHFEVT FQQSSTAKSA TWTYSPLLKK LYCQIAKTCP IQIKVSTPPP PGTAIRAMPV
       190        200        210        220        230        240
YKKAEHVTDV VKRCPNHELG RDFNEGQSAP ASHLIRVEGN NLSQYVDDPV TGRQSVVVPY
       250        260        270        280        290        300
EPPQVGTEFT TILYNFMCNS SCVGGMNRRP ILIIITLEMR DGQVLGRRSF EGRICACPGR
       310        320        330        340        350        360
DRKADEDHYR EQQALNESSA KNGAASKRAF KQSPPAVPAL GAGVKKRRHG DEDTYYLQVR
       370        380        390        400        410        420
GRENFEILMK LKESLELMEL VPQPLVDSYR QQQQLLQRPS HLQPPSYGPV LSPMNKVHGG
       430        440        450        460        470        480
MNKLPSVNQL VGQPPPHSSA ATPNLGPVGP GMLNNHGHAV PANGEMSSSH SAQSMVSGSH
       490        500        510        520        530        540
CTPPPPYHAD PSLVSFLTGL GCPNCIEYFT SQGLQSIYHL QNLTIEDLGA LKIPEQYRMT
       550        560        570        580        590        600
IWRGLQDLKQ GHDYSTAQQL LRSSNAATIS IGGSGELQRQ RVMEAVHFRV RHTITIPNRG
       610        620        630
GPGGGPDEWA DFGFDLPDCK ARKQPIKEEF TEAEIH         10         20         30         40         50         60
MAQSTATSPD GGTTFEHLWS SLEPDSTYFD LPQSSRGNNE VVGGTDSSMD VFHLEGMTTS
        70         80         90        100        110        120
VMAQFNLLSS TMDQMSSRAA SASPYTPEHA ASVPTHSPYA QPSSTFDTMS PAPVIPSNTD
       130        140        150        160        170        180
YPGPHHFEVT FQQSSTAKSA TWTYSPLLKK LYCQIAKTCP IQIKVSTPPP PGTAIRAMPV
       190        200        210        220        230        240
YKKAEHVTDV VKRCPNHELG RDFNEGQSAP ASHLIRVEGN NLSQYVDDPV TGRQSVVVPY
       250        260        270        280        290        300
EPPQVGTEFT TILYNFMCNS SCVGGMNRRP ILIIITLEMR DGQVLGRRSF EGRICACPGR
       310        320        330        340        350        360
DRKADEDHYR EQQALNESSA KNGAASKRAF KQSPPAVPAL GAGVKKRRHG DEDTYYLQVR
       370        380        390        400        410        420
GRENFEILMK LKESLELMEL VPQPLVDSYR QQQQLLQRPS HLQPPSYGPV LSPMNKVHGG
       430        440        450        460        470        480
MNKLPSVNQL VGQPPPHSSA ATPNLGPVGP GMLNNHGHAV PANGEMSSSH SAQSMVSGSH
       490        500        510        520        530        540
CTPPPPYHAD PSLVSFLTGL GCPNCIEYFT SQGLQSIYHL QNLTIEDLGA LKIPEQYRMT
       550        560        570        580        590        600
IWRGLQDLKQ GHDYSTAQQL LRSSNAATIS IGGSGELQRQ RVMEAVHFRV RHTITIPNRG
       610        620        630
GPGGGPDEWA DFGFDLPDCK ARKQPIKEEF TEAEIH         10         20         30         40         50         60
MAQSTATSPD GGTTFEHLWS SLEPDSTYFD LPQSSRGNNE VVGGTDSSMD VFHLEGMTTS
        70         80         90        100        110        120
VMAQFNLLSS TMDQMSSRAA SASPYTPEHA ASVPTHSPYA QPSSTFDTMS PAPVIPSNTD
       130        140        150        160        170        180
YPGPHHFEVT FQQSSTAKSA TWTYSPLLKK LYCQIAKTCP IQIKVSTPPP PGTAIRAMPV
       190        200        210        220        230        240
YKKAEHVTDV VKRCPNHELG RDFNEGQSAP ASHLIRVEGN NLSQYVDDPV TGRQSVVVPY
       250        260        270        280        290        300
EPPQVGTEFT TILYNFMCNS SCVGGMNRRP ILIIITLEMR DGQVLGRRSF EGRICACPGR
       310        320        330        340        350        360
DRKADEDHYR EQQALNESSA KNGAASKRAF KQSPPAVPAL GAGVKKRRHG DEDTYYLQVR
       370        380        390        400        410        420
GRENFEILMK LKESLELMEL VPQPLVDSYR QQQQLLQRPS HLQPPSYGPV LSPMNKVHGG
       430        440        450        460        470        480
MNKLPSVNQL VGQPPPHSSA ATPNLGPVGP GMLNNHGHAV PANGEMSSSH SAQSMVSGSH
       490        500        510        520        530        540
CTPPPPYHAD PSLVSFLTGL GCPNCIEYFT SQGLQSIYHL QNLTIEDLGA LKIPEQYRMT
       550        560        570        580        590        600
IWRGLQDLKQ GHDYSTAQQL LRSSNAATIS IGGSGELQRQ RVMEAVHFRV RHTITIPNRG
       610        620        630
GPGGGPDEWA DFGFDLPDCK ARKQPIKEEF TEAEIH         10         20         30         40         50         60
MAQSTATSPD GGTTFEHLWS SLEPDSTYFD LPQSSRGNNE VVGGTDSSMD VFHLEGMTTS
        70         80         90        100        110        120
VMAQFNLLSS TMDQMSSRAA SASPYTPEHA ASVPTHSPYA QPSSTFDTMS PAPVIPSNTD
       130        140        150        160        170        180
YPGPHHFEVT FQQSSTAKSA TWTYSPLLKK LYCQIAKTCP IQIKVSTPPP PGTAIRAMPV
       190        200        210        220        230        240
YKKAEHVTDV VKRCPNHELG RDFNEGQSAP ASHLIRVEGN NLSQYVDDPV TGRQSVVVPY
       250        260        270        280        290        300
EPPQVGTEFT TILYNFMCNS SCVGGMNRRP ILIIITLEMR DGQVLGRRSF EGRICACPGR
       310        320        330        340        350        360
DRKADEDHYR EQQALNESSA KNGAASKRAF KQSPPAVPAL GAGVKKRRHG DEDTYYLQVR
       370        380        390        400        410        420
GRENFEILMK LKESLELMEL VPQPLVDSYR QQQQLLQRPS HLQPPSYGPV LSPMNKVHGG
       430        440        450        460        470        480
MNKLPSVNQL VGQPPPHSSA ATPNLGPVGP GMLNNHGHAV PANGEMSSSH SAQSMVSGSH
       490        500        510        520        530        540
CTPPPPYHAD PSLVSFLTGL GCPNCIEYFT SQGLQSIYHL QNLTIEDLGA LKIPEQYRMT
       550        560        570        580        590        600
IWRGLQDLKQ GHDYSTAQQL LRSSNAATIS IGGSGELQRQ RVMEAVHFRV RHTITIPNRG
       610        620        630
GPGGGPDEWA DFGFDLPDCK ARKQPIKEEF TEAEIH         10         20         30         40         50         60
MAQSTATSPD GGTTFEHLWS SLEPDSTYFD LPQSSRGNNE VVGGTDSSMD VFHLEGMTTS
        70         80         90        100        110        120
VMAQFNLLSS TMDQMSSRAA SASPYTPEHA ASVPTHSPYA QPSSTFDTMS PAPVIPSNTD
       130        140        150        160        170        180
YPGPHHFEVT FQQSSTAKSA TWTYSPLLKK LYCQIAKTCP IQIKVSTPPP PGTAIRAMPV
       190        200        210        220        230        240
YKKAEHVTDV VKRCPNHELG RDFNEGQSAP ASHLIRVEGN NLSQYVDDPV TGRQSVVVPY
       250        260        270        280        290        300
EPPQVGTEFT TILYNFMCNS SCVGGMNRRP ILIIITLEMR DGQVLGRRSF EGRICACPGR
       310        320        330        340        350        360
DRKADEDHYR EQQALNESSA KNGAASKRAF KQSPPAVPAL GAGVKKRRHG DEDTYYLQVR
       370        380        390        400        410        420
GRENFEILMK LKESLELMEL VPQPLVDSYR QQQQLLQRPS HLQPPSYGPV LSPMNKVHGG
       430        440        450        460        470        480
MNKLPSVNQL VGQPPPHSSA ATPNLGPVGP GMLNNHGHAV PANGEMSSSH SAQSMVSGSH
       490        500        510        520        530        540
CTPPPPYHAD PSLVSFLTGL GCPNCIEYFT SQGLQSIYHL QNLTIEDLGA LKIPEQYRMT
       550        560        570        580        590        600
IWRGLQDLKQ GHDYSTAQQL LRSSNAATIS IGGSGELQRQ RVMEAVHFRV RHTITIPNRG
       610        620        630
GPGGGPDEWA DFGFDLPDCK ARKQPIKEEF TEAEIH         10         20         30         40         50         60
MAQSTATSPD GGTTFEHLWS SLEPDSTYFD LPQSSRGNNE VVGGTDSSMD VFHLEGMTTS
        70         80         90        100        110        120
VMAQFNLLSS TMDQMSSRAA SASPYTPEHA ASVPTHSPYA QPSSTFDTMS PAPVIPSNTD
       130        140        150        160        170        180
YPGPHHFEVT FQQSSTAKSA TWTYSPLLKK LYCQIAKTCP IQIKVSTPPP PGTAIRAMPV
       190        200        210        220        230        240
YKKAEHVTDV VKRCPNHELG RDFNEGQSAP ASHLIRVEGN NLSQYVDDPV TGRQSVVVPY
       250        260        270        280        290        300
EPPQVGTEFT TILYNFMCNS SCVGGMNRRP ILIIITLEMR DGQVLGRRSF EGRICACPGR
       310        320        330        340        350        360
DRKADEDHYR EQQALNESSA KNGAASKRAF KQSPPAVPAL GAGVKKRRHG DEDTYYLQVR
       370        380        390        400        410        420
GRENFEILMK LKESLELMEL VPQPLVDSYR QQQQLLQRPS HLQPPSYGPV LSPMNKVHGG
       430        440        450        460        470        480
MNKLPSVNQL VGQPPPHSSA ATPNLGPVGP GMLNNHGHAV PANGEMSSSH SAQSMVSGSH
       490        500        510        520        530        540
CTPPPPYHAD PSLVSFLTGL GCPNCIEYFT SQGLQSIYHL QNLTIEDLGA LKIPEQYRMT
       550        560        570        580        590        600
IWRGLQDLKQ GHDYSTAQQL LRSSNAATIS IGGSGELQRQ RVMEAVHFRV RHTITIPNRG
       610        620        630
GPGGGPDEWA DFGFDLPDCK ARKQPIKEEF TEAEIH

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O15350-1-unknown	MAQSTA...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O15350-1-unknown	MAQSTA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84096
O15350-1-unknown	MAQSTA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84097
O15350-1-unknown	MAQSTA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84098
O15350-1-unknown	MAQSTA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84099
O15350-1-unknown	MAQSTA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84100
O15350-72-unknown	MDQMSS...	72	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000367539
O15350-72-unknown	MDQMSS...	72	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196516
O15350-72-unknown	MDQMSS...	72	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196517
O15350-72-unknown	MDQMSS...	72	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196518
O15350-72-unknown	MDQMSS...	72	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196519
O15350-72-unknown	MDQMSS...	72	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196520
O15350-72-unknown	MDQMSS...	72	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196521
O15350-72-unknown	MDQMSS...	72	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196522

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EAEIH	636	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EAEIH	636	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79718
...EAEIH	636	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79717
...EAEIH	636	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79719

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)