O15393: Transmembrane protease serine 2

General Information

Protein names	- Transmembrane protease serine 2 - 3.4.21.- - Serine protease 10 - Transmembrane protease serine 2 non-catalytic chain - Transmembrane protease serine 2 catalytic chain
Gene names	TMPRSS2
Organism	Homo sapiens
Protease Family
Protease ID	S01.247
Chromosome location
UniProt ID	O15393

2 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MALNSGSPPA IGPYYENHGY QPENPYPAQP TVVPTVYEVH PAQYYPSPVP QYAPRVLTQA
        70         80         90        100        110        120
SNPVVCTQPK SPSGTVCTSK TKKALCITLT LGTFLVGAAL AAGLLWKFMG SKCSNSGIEC
       130        140        150        160        170        180
DSSGTCINPS NWCDGVSHCP GGEDENRCVR LYGPNFILQV YSSQRKSWHP VCQDDWNENY
       190        200        210        220        230        240
GRAACRDMGY KNNFYSSQGI VDDSGSTSFM KLNTSAGNVD IYKKLYHSDA CSSKAVVSLR
       250        260        270        280        290        300
CIACGVNLNS SRQSRIVGGE SALPGAWPWQ VSLHVQNVHV CGGSIITPEW IVTAAHCVEK
       310        320        330        340        350        360
PLNNPWHWTA FAGILRQSFM FYGAGYQVEK VISHPNYDSK TKNNDIALMK LQKPLTFNDL
       370        380        390        400        410        420
VKPVCLPNPG MMLQPEQLCW ISGWGATEEK GKTSEVLNAA KVLLIETQRC NSRYVYDNLI
       430        440        450        460        470        480
TPAMICAGFL QGNVDSCQGD SGGPLVTSKN NIWWLIGDTS WGSGCAKAYR PGVYGNVMVF
       490
TDWIYRQMRA DG

Isoforms

- Isoform 2 of Transmembrane protease serine 2

Sequence View

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O15393-1-unknown	MALNSG...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O15393-1-unknown	MALNSG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt100873
O15393-256-unknown	IVGGES...	256	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O15393-256-unknown	IVGGES...	256	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116103

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SRQSRI	255	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SRQSRI	255	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92106
...MRADG	492	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...MRADG	492	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88156

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

TopFIND

O15393: Transmembrane protease serine 2

General Information

2

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

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Physiological Relevance:

Evidence Codes:

Methodology:

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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates