TopFIND 4.0

O15460: Prolyl 4-hydroxylase subunit alpha-2

General Information

Protein names
- Prolyl 4-hydroxylase subunit alpha-2
- 4-PH alpha-2
- 1.14.11.2
- Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2
Gene names P4HA2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID O15460

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MKLWVSALLM AWFGVLSCVQ AEFFTSIGHM TDLIYAEKEL VQSLKEYILV EEAKLSKIKS 
        70         80         90        100        110        120 
WANKMEALTS KSAADAEGYL AHPVNAYKLV KRLNTDWPAL EDLVLQDSAA GFIANLSVQR 
       130        140        150        160        170        180 
QFFPTDEDEI GAAKALMRLQ DTYRLDPGTI SRGELPGTKY QAMLSVDDCF GMGRSAYNEG 
       190        200        210        220        230        240 
DYYHTVLWME QVLKQLDAGE EATTTKSQVL DYLSYAVFQL GDLHRALELT RRLLSLDPSH 
       250        260        270        280        290        300 
ERAGGNLRYF EQLLEEEREK TLTNQTEAEL ATPEGIYERP VDYLPERDVY ESLCRGEGVK 
       310        320        330        340        350        360 
LTPRRQKRLF CRYHHGNRAP QLLIAPFKEE DEWDSPHIVR YYDVMSDEEI ERIKEIAKPK 
       370        380        390        400        410        420 
LARATVRDPK TGVLTVASYR VSKSSWLEED DDPVVARVNR RMQHITGLTV KTAELLQVAN 
       430        440        450        460        470        480 
YGVGGQYEPH FDFSRNDERD TFKHLGTGNR VATFLNYMSD VEAGGATVFP DLGAAIWPKK 
       490        500        510        520        530    
GTAVFWYNLL RSGEGDYRTR HAACPVLVGC KWVSNKWFHE RGQEFLRPCG STEVD

Isoforms

- Isoform IIa of Prolyl 4-hydroxylase subunit alpha-2

Sequence View

        10         20         30         40         50         60 
MKLWVSALLM AWFGVLSCVQ AEFFTSIGHM TDLIYAEKEL VQSLKEYILV EEAKLSKIKS 
        70         80         90        100        110        120 
WANKMEALTS KSAADAEGYL AHPVNAYKLV KRLNTDWPAL EDLVLQDSAA GFIANLSVQR 
       130        140        150        160        170        180 
QFFPTDEDEI GAAKALMRLQ DTYRLDPGTI SRGELPGTKY QAMLSVDDCF GMGRSAYNEG 
       190        200        210        220        230        240 
DYYHTVLWME QVLKQLDAGE EATTTKSQVL DYLSYAVFQL GDLHRALELT RRLLSLDPSH 
       250        260        270        280        290        300 
ERAGGNLRYF EQLLEEEREK TLTNQTEAEL ATPEGIYERP VDYLPERDVY ESLCRGEGVK 
       310        320        330        340        350        360 
LTPRRQKRLF CRYHHGNRAP QLLIAPFKEE DEWDSPHIVR YYDVMSDEEI ERIKEIAKPK 
       370        380        390        400        410        420 
LARATVRDPK TGVLTVASYR VSKSSWLEED DDPVVARVNR RMQHITGLTV KTAELLQVAN 
       430        440        450        460        470        480 
YGVGGQYEPH FDFSRNDERD TFKHLGTGNR VATFLNYMSD VEAGGATVFP DLGAAIWPKK 
       490        500        510        520        530    
GTAVFWYNLL RSGEGDYRTR HAACPVLVGC KWVSNKWFHE RGQEFLRPCG STEVD



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(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


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Lab:



Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    O15460-1-unknown MKLWVS... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt84043
    O15460-22-unknown EFFTSI... 22 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    O15460-22-unknown EFFTSI... 22 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt113099

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...STEVD 535 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...STEVD 535 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt79661

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)