O15519: CASP8 and FADD-like apoptosis regulator

General Information

Protein names	- CASP8 and FADD-like apoptosis regulator - Caspase homolog - CASH - Caspase-eight-related protein - Casper - Caspase-like apoptosis regulatory protein - CLARP - Cellular FLICE-like inhibitory protein - c-FLIP - FADD-like antiapoptotic molecule 1 - FLAME-1 - Inhibitor of FLICE - I-FLICE - MACH-related inducer of toxicity - MRIT - Usurpin - CASP8 and FADD-like apoptosis regulator subunit p43 - CASP8 and FADD-like apoptosis regulator subunit p12
Gene names	CFLAR
Organism	Homo sapiens
Protease Family
Protease ID	C14.971
Chromosome location
UniProt ID	O15519

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of CASP8 and FADD-like apoptosis regulator - Isoform 3 of CASP8 and FADD-like apoptosis regulator - Isoform 4 of CASP8 and FADD-like apoptosis regulator - Isoform 5 of CASP8 and FADD-like apoptosis regulator - Isoform 6 of CASP8 and FADD-like apoptosis regulator - Isoform 7 of CASP8 and FADD-like apoptosis regulator - Isoform 8 of CASP8 and FADD-like apoptosis regulator - Isoform 9 of CASP8 and FADD-like apoptosis regulator - Isoform 10 of CASP8 and FADD-like apoptosis regulator - Isoform 11 of CASP8 and FADD-like apoptosis regulator - Isoform 12 of CASP8 and FADD-like apoptosis regulator - Isoform 13 of CASP8 and FADD-like apoptosis regulator - Isoform 14 of CASP8 and FADD-like apoptosis regulator - Isoform 15 of CASP8 and FADD-like apoptosis regulator

Sequence View

        10         20         30         40         50         60
MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY
        70         80         90        100        110        120
RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM
       130        140        150        160        170        180
GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT
       190        200        210        220        230        240
SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP
       250        260        270        280        290        300
EERYKMKSKP LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP
       310        320        330        340        350        360
EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG KPKMFFIQNY
       370        380        390        400        410        420
VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD FFWSLCTADM SLLEQSHSSP
       430        440        450        460        470        480
SLYLQCLSQK LRQERKRPLL DLHIELNGYM YDWNSRVSAK EKYYVWLQHT LRKKLILSYT

        10         20         30         40         50         60
MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY
        70         80         90        100        110        120
RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM
       130        140        150        160        170        180
GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT
       190        200        210        220        230        240
SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP
       250        260        270        280        290        300
EERYKMKSKP LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP
       310        320        330        340        350        360
EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG KPKMFFIQNY
       370        380        390        400        410        420
VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD FFWSLCTADM SLLEQSHSSP
       430        440        450        460        470        480
SLYLQCLSQK LRQERKRPLL DLHIELNGYM YDWNSRVSAK EKYYVWLQHT LRKKLILSYT

        10         20         30         40         50         60
MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY
        70         80         90        100        110        120
RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM
       130        140        150        160        170        180
GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT
       190        200        210        220        230        240
SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP
       250        260        270        280        290        300
EERYKMKSKP LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP
       310        320        330        340        350        360
EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG KPKMFFIQNY
       370        380        390        400        410        420
VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD FFWSLCTADM SLLEQSHSSP
       430        440        450        460        470        480
SLYLQCLSQK LRQERKRPLL DLHIELNGYM YDWNSRVSAK EKYYVWLQHT LRKKLILSYT

        10         20         30         40         50         60
MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY
        70         80         90        100        110        120
RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM
       130        140        150        160        170        180
GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT
       190        200        210        220        230        240
SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP
       250        260        270        280        290        300
EERYKMKSKP LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP
       310        320        330        340        350        360
EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG KPKMFFIQNY
       370        380        390        400        410        420
VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD FFWSLCTADM SLLEQSHSSP
       430        440        450        460        470        480
SLYLQCLSQK LRQERKRPLL DLHIELNGYM YDWNSRVSAK EKYYVWLQHT LRKKLILSYT

        10         20         30         40         50         60
MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY
        70         80         90        100        110        120
RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM
       130        140        150        160        170        180
GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT
       190        200        210        220        230        240
SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP
       250        260        270        280        290        300
EERYKMKSKP LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP
       310        320        330        340        350        360
EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG KPKMFFIQNY
       370        380        390        400        410        420
VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD FFWSLCTADM SLLEQSHSSP
       430        440        450        460        470        480
SLYLQCLSQK LRQERKRPLL DLHIELNGYM YDWNSRVSAK EKYYVWLQHT LRKKLILSYT

        10         20         30         40         50         60
MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY
        70         80         90        100        110        120
RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM
       130        140        150        160        170        180
GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT
       190        200        210        220        230        240
SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP
       250        260        270        280        290        300
EERYKMKSKP LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP
       310        320        330        340        350        360
EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG KPKMFFIQNY
       370        380        390        400        410        420
VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD FFWSLCTADM SLLEQSHSSP
       430        440        450        460        470        480
SLYLQCLSQK LRQERKRPLL DLHIELNGYM YDWNSRVSAK EKYYVWLQHT LRKKLILSYT

        10         20         30         40         50         60
MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY
        70         80         90        100        110        120
RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM
       130        140        150        160        170        180
GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT
       190        200        210        220        230        240
SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP
       250        260        270        280        290        300
EERYKMKSKP LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP
       310        320        330        340        350        360
EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG KPKMFFIQNY
       370        380        390        400        410        420
VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD FFWSLCTADM SLLEQSHSSP
       430        440        450        460        470        480
SLYLQCLSQK LRQERKRPLL DLHIELNGYM YDWNSRVSAK EKYYVWLQHT LRKKLILSYT

        10         20         30         40         50         60
MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY
        70         80         90        100        110        120
RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM
       130        140        150        160        170        180
GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT
       190        200        210        220        230        240
SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP
       250        260        270        280        290        300
EERYKMKSKP LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP
       310        320        330        340        350        360
EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG KPKMFFIQNY
       370        380        390        400        410        420
VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD FFWSLCTADM SLLEQSHSSP
       430        440        450        460        470        480
SLYLQCLSQK LRQERKRPLL DLHIELNGYM YDWNSRVSAK EKYYVWLQHT LRKKLILSYT

        10         20         30         40         50         60
MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY
        70         80         90        100        110        120
RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM
       130        140        150        160        170        180
GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT
       190        200        210        220        230        240
SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP
       250        260        270        280        290        300
EERYKMKSKP LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP
       310        320        330        340        350        360
EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG KPKMFFIQNY
       370        380        390        400        410        420
VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD FFWSLCTADM SLLEQSHSSP
       430        440        450        460        470        480
SLYLQCLSQK LRQERKRPLL DLHIELNGYM YDWNSRVSAK EKYYVWLQHT LRKKLILSYT

        10         20         30         40         50         60
MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY
        70         80         90        100        110        120
RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM
       130        140        150        160        170        180
GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT
       190        200        210        220        230        240
SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP
       250        260        270        280        290        300
EERYKMKSKP LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP
       310        320        330        340        350        360
EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG KPKMFFIQNY
       370        380        390        400        410        420
VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD FFWSLCTADM SLLEQSHSSP
       430        440        450        460        470        480
SLYLQCLSQK LRQERKRPLL DLHIELNGYM YDWNSRVSAK EKYYVWLQHT LRKKLILSYT

        10         20         30         40         50         60
MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY
        70         80         90        100        110        120
RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM
       130        140        150        160        170        180
GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT
       190        200        210        220        230        240
SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP
       250        260        270        280        290        300
EERYKMKSKP LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP
       310        320        330        340        350        360
EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG KPKMFFIQNY
       370        380        390        400        410        420
VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD FFWSLCTADM SLLEQSHSSP
       430        440        450        460        470        480
SLYLQCLSQK LRQERKRPLL DLHIELNGYM YDWNSRVSAK EKYYVWLQHT LRKKLILSYT

        10         20         30         40         50         60
MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY
        70         80         90        100        110        120
RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM
       130        140        150        160        170        180
GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT
       190        200        210        220        230        240
SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP
       250        260        270        280        290        300
EERYKMKSKP LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP
       310        320        330        340        350        360
EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG KPKMFFIQNY
       370        380        390        400        410        420
VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD FFWSLCTADM SLLEQSHSSP
       430        440        450        460        470        480
SLYLQCLSQK LRQERKRPLL DLHIELNGYM YDWNSRVSAK EKYYVWLQHT LRKKLILSYT

        10         20         30         40         50         60
MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY
        70         80         90        100        110        120
RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM
       130        140        150        160        170        180
GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT
       190        200        210        220        230        240
SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP
       250        260        270        280        290        300
EERYKMKSKP LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP
       310        320        330        340        350        360
EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG KPKMFFIQNY
       370        380        390        400        410        420
VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD FFWSLCTADM SLLEQSHSSP
       430        440        450        460        470        480
SLYLQCLSQK LRQERKRPLL DLHIELNGYM YDWNSRVSAK EKYYVWLQHT LRKKLILSYT

        10         20         30         40         50         60
MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY
        70         80         90        100        110        120
RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM
       130        140        150        160        170        180
GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT
       190        200        210        220        230        240
SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP
       250        260        270        280        290        300
EERYKMKSKP LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP
       310        320        330        340        350        360
EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG KPKMFFIQNY
       370        380        390        400        410        420
VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD FFWSLCTADM SLLEQSHSSP
       430        440        450        460        470        480
SLYLQCLSQK LRQERKRPLL DLHIELNGYM YDWNSRVSAK EKYYVWLQHT LRKKLILSYT

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O15519-1-unknown	MSAEVI...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O15519-1-unknown	MSAEVI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt70420
O15519-1-unknown	MSAEVI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt70423
O15519-1-unknown	MSAEVI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt70426
O15519-1-unknown	MSAEVI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt70427
O15519-97-unknown	MAEIGE...	97	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt70421
O15519-97-unknown	MAEIGE...	97	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt70425
O15519-97-unknown	MAEIGE...	97	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97065
O15519-97-unknown	MAEIGE...	97	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97063
O15519-97-unknown	MAEIGE...	97	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97064
O15519-97-unknown	MAEIGE...	97	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97066
O15519-97-unknown	MAEIGE...	97	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97067
O15519-246-unknown	MKSKPL...	246	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt70422
O15519-246-unknown	MKSKPL...	246	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97124
O15519-246-unknown	MKSKPL...	246	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97127
O15519-246-unknown	MKSKPL...	246	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97122
O15519-246-unknown	MKSKPL...	246	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97123
O15519-246-unknown	MKSKPL...	246	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97125
O15519-246-unknown	MKSKPL...	246	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97126
O15519-377-unknown	GPAMKN...	377	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O15519-377-unknown	GPAMKN...	377	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2984
O15519-377-unknown	GPAMKN...	377	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116180
O15519-377-unknown	GPAMKN...	377	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116177
O15519-377-unknown	GPAMKN...	377	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116181
O15519-377-unknown	GPAMKN...	377	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116176
O15519-377-unknown	GPAMKN...	377	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116178
O15519-377-unknown	GPAMKN...	377	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116179

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LLEVDG	376	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LLEVDG	376	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2984
...LLEVDG	376	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92584
...LLEVDG	376	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92581
...LLEVDG	376	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92585
...LLEVDG	376	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92580
...LLEVDG	376	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92582
...LLEVDG	376	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92583
...ILSYT	480	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ILSYT	480	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66040
...ILSYT	480	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66044

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP8_HUMAN	376	EVDG.\|.GPAM	inferred from experiment	unknown	MEROPS	Imajoh-Ohmi S	Niikura Y et al.:Monitoring of caspase-8/FLICE p... (C14.009)	12097160,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)