TopFIND 4.0

O35453: Serine protease hepsin

General Information

Protein names
- Serine protease hepsin
- 3.4.21.106 {ECO:0000305|PubMed:26673890, ECO:0000305|PubMed:9395459}
- Serine protease hepsin non-catalytic chain
- Serine protease hepsin catalytic chain
Gene names Hpn
Organism Mus musculus
Protease Family S01.224
Protease ID S01.224
Chromosome location
UniProt ID O35453

2

N-termini

2

C-termini

0

Cleavages

1

Substrates

Sequence

        10         20         30         40         50         60 
MAKEDEEPGA HRGGSTCSRP QPGKGGRTAA CCSRPKVAAL IVGTLLFLTG IGAASWAIVT 
        70         80         90        100        110        120 
ILLQSDQEPL YQVQLSPGDS RLAVFDKTEG TWRLLCSSRS NARVAGLGCE EMGFLRALAH 
       130        140        150        160        170        180 
SELDVRTAGA NGTSGFFCVD EGGLPLAQRL LDVISVCDCP RGRFLTATCQ DCGRRKLPVD 
       190        200        210        220        230        240 
RIVGGQDSSL GRWPWQVSLR YDGTHLCGGS LLSGDWVLTA AHCFPERNRV LSRWRVFAGA 
       250        260        270        280        290        300 
VARTSPHAVQ LGVQAVIYHG GYLPFRDPTI DENSNDIALV HLSSSLPLTE YIQPVCLPAA 
       310        320        330        340        350        360 
GQALVDGKVC TVTGWGNTQF YGQQAMVLQE ARVPIISNEV CNSPDFYGNQ IKPKMFCAGY 
       370        380        390        400        410        420 
PEGGIDACQG DSGGPFVCED SISGTSRWRL CGIVSWGTGC ALARKPGVYT KVTDFREWIF 
       430    
KAIKTHSEAS GMVTQP

Isoforms

- Isoform 2 of Serine protease hepsin

Sequence View

        10         20         30         40         50         60 
MAKEDEEPGA HRGGSTCSRP QPGKGGRTAA CCSRPKVAAL IVGTLLFLTG IGAASWAIVT 
        70         80         90        100        110        120 
ILLQSDQEPL YQVQLSPGDS RLAVFDKTEG TWRLLCSSRS NARVAGLGCE EMGFLRALAH 
       130        140        150        160        170        180 
SELDVRTAGA NGTSGFFCVD EGGLPLAQRL LDVISVCDCP RGRFLTATCQ DCGRRKLPVD 
       190        200        210        220        230        240 
RIVGGQDSSL GRWPWQVSLR YDGTHLCGGS LLSGDWVLTA AHCFPERNRV LSRWRVFAGA 
       250        260        270        280        290        300 
VARTSPHAVQ LGVQAVIYHG GYLPFRDPTI DENSNDIALV HLSSSLPLTE YIQPVCLPAA 
       310        320        330        340        350        360 
GQALVDGKVC TVTGWGNTQF YGQQAMVLQE ARVPIISNEV CNSPDFYGNQ IKPKMFCAGY 
       370        380        390        400        410        420 
PEGGIDACQG DSGGPFVCED SISGTSRWRL CGIVSWGTGC ALARKPGVYT KVTDFREWIF 
       430    
KAIKTHSEAS GMVTQP



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Biological System:


Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 1 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    O35453-1-unknown MAKEDE... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    O35453-1-unknown MAKEDE... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt76920
    O35453-182-unknown IVGGQD... 182 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    O35453-182-unknown IVGGQD... 182 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt115997

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates