O35569: Pro-neuregulin-2, membrane-bound isoform

General Information

Protein names	- Pro-neuregulin-2, membrane-bound isoform - Pro-NRG2 - Neuregulin-2 - NRG-2 - Neural- and thymus-derived activator for ERBB kinases - NTAK
Gene names	Nrg2
Organism	Rattus norvegicus
Protease Family
Protease ID
Chromosome location
UniProt ID	O35569

3 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Pro-neuregulin-2, membrane-bound isoform - Isoform 3 of Pro-neuregulin-2, membrane-bound isoform - Isoform 4 of Pro-neuregulin-2, membrane-bound isoform - Isoform 5 of Pro-neuregulin-2, membrane-bound isoform - Isoform 6 of Pro-neuregulin-2, membrane-bound isoform - Isoform 7 of Pro-neuregulin-2, membrane-bound isoform

Sequence View

        10         20         30         40         50         60
MRQVCCSALP PPLEKARCSS YSYSDSSSSS SSNNSSSSTS SRSSSRSSSR SSRGSTTTTS
        70         80         90        100        110        120
SSENSGSNSG SIFRPAAPPE PRPQPQPQPR SPAARRAAAR SRAAAAGGMR RDPAPGSSML
       130        140        150        160        170        180
LFGVSLACYS PSLKSVQDQA YKAPVVVEGK VQGLAPAGGS SSNSTREPPA SGRVALVKVL
       190        200        210        220        230        240
DKWPLRSGGL QREQVISVGS CAPLERNQRY IFFLEPTEQP LVFKTAFAPV DPNGKNIKKE
       250        260        270        280        290        300
VGKILCTDCA TRPKLKKMKS QTGEVGEKQS LKCEAAAGNP QPSYRWFKDG KELNRSRDIR
       310        320        330        340        350        360
IKYGNGRKNS RLQFNKVKVE DAGEYVCEAE NILGKDTVRG RLHVNSVSTT LSSWSGHARK
       370        380        390        400        410        420
CNETAKSYCV NGGVCYYIEG INQLSCKCPN GFFGQRCLEK LPLRLYMPDP KQKHLGFELK
       430        440        450        460        470        480
EAEELYQKRV LTITGICVAL LVVGIVCVVA YCKTKKQRRQ MHHHLRQNMC PAHQNRSLAN
       490        500        510        520        530        540
GPSHPRLDPE EIQMADYISK NVPATDHVIR REAETTFSGS HSCSPSHHCS TATPTSSHRH
       550        560        570        580        590        600
ESHTWSLERS ESLTSDSQSG IMLSSVGTSK CNSPACVEAR ARRAAAYSQE ERRRAAMPPY
       610        620        630        640        650        660
HDSIDSLRDS PHSERYVSAL TTPARLSPVD FHYSLATQVP TFEITSPNSA HAVSLPPAAP
       670        680        690        700        710        720
ISYRLAEQQP LLRHPAPPGP GPGPGADMQR SYDSYYYPAA GPGPRRGACA LGGSLGSLPA
       730        740        750        760        770        780
SPFRIPEDDE YETTQECAPP PPPRPRTRGA SRRTSAGPRR WRRSRLNGLA AQRARAARDS
       790        800        810        820        830        840
LSLSSGSGCG SASASDDDAD DADGALAAES TPFLGLRAAH DALRSDSPPL CPAADSRTYY
       850        860
SLDSHSTRAS SRHSRGPPTR AKQDSGPL         10         20         30         40         50         60
MRQVCCSALP PPLEKARCSS YSYSDSSSSS SSNNSSSSTS SRSSSRSSSR SSRGSTTTTS
        70         80         90        100        110        120
SSENSGSNSG SIFRPAAPPE PRPQPQPQPR SPAARRAAAR SRAAAAGGMR RDPAPGSSML
       130        140        150        160        170        180
LFGVSLACYS PSLKSVQDQA YKAPVVVEGK VQGLAPAGGS SSNSTREPPA SGRVALVKVL
       190        200        210        220        230        240
DKWPLRSGGL QREQVISVGS CAPLERNQRY IFFLEPTEQP LVFKTAFAPV DPNGKNIKKE
       250        260        270        280        290        300
VGKILCTDCA TRPKLKKMKS QTGEVGEKQS LKCEAAAGNP QPSYRWFKDG KELNRSRDIR
       310        320        330        340        350        360
IKYGNGRKNS RLQFNKVKVE DAGEYVCEAE NILGKDTVRG RLHVNSVSTT LSSWSGHARK
       370        380        390        400        410        420
CNETAKSYCV NGGVCYYIEG INQLSCKCPN GFFGQRCLEK LPLRLYMPDP KQKHLGFELK
       430        440        450        460        470        480
EAEELYQKRV LTITGICVAL LVVGIVCVVA YCKTKKQRRQ MHHHLRQNMC PAHQNRSLAN
       490        500        510        520        530        540
GPSHPRLDPE EIQMADYISK NVPATDHVIR REAETTFSGS HSCSPSHHCS TATPTSSHRH
       550        560        570        580        590        600
ESHTWSLERS ESLTSDSQSG IMLSSVGTSK CNSPACVEAR ARRAAAYSQE ERRRAAMPPY
       610        620        630        640        650        660
HDSIDSLRDS PHSERYVSAL TTPARLSPVD FHYSLATQVP TFEITSPNSA HAVSLPPAAP
       670        680        690        700        710        720
ISYRLAEQQP LLRHPAPPGP GPGPGADMQR SYDSYYYPAA GPGPRRGACA LGGSLGSLPA
       730        740        750        760        770        780
SPFRIPEDDE YETTQECAPP PPPRPRTRGA SRRTSAGPRR WRRSRLNGLA AQRARAARDS
       790        800        810        820        830        840
LSLSSGSGCG SASASDDDAD DADGALAAES TPFLGLRAAH DALRSDSPPL CPAADSRTYY
       850        860
SLDSHSTRAS SRHSRGPPTR AKQDSGPL         10         20         30         40         50         60
MRQVCCSALP PPLEKARCSS YSYSDSSSSS SSNNSSSSTS SRSSSRSSSR SSRGSTTTTS
        70         80         90        100        110        120
SSENSGSNSG SIFRPAAPPE PRPQPQPQPR SPAARRAAAR SRAAAAGGMR RDPAPGSSML
       130        140        150        160        170        180
LFGVSLACYS PSLKSVQDQA YKAPVVVEGK VQGLAPAGGS SSNSTREPPA SGRVALVKVL
       190        200        210        220        230        240
DKWPLRSGGL QREQVISVGS CAPLERNQRY IFFLEPTEQP LVFKTAFAPV DPNGKNIKKE
       250        260        270        280        290        300
VGKILCTDCA TRPKLKKMKS QTGEVGEKQS LKCEAAAGNP QPSYRWFKDG KELNRSRDIR
       310        320        330        340        350        360
IKYGNGRKNS RLQFNKVKVE DAGEYVCEAE NILGKDTVRG RLHVNSVSTT LSSWSGHARK
       370        380        390        400        410        420
CNETAKSYCV NGGVCYYIEG INQLSCKCPN GFFGQRCLEK LPLRLYMPDP KQKHLGFELK
       430        440        450        460        470        480
EAEELYQKRV LTITGICVAL LVVGIVCVVA YCKTKKQRRQ MHHHLRQNMC PAHQNRSLAN
       490        500        510        520        530        540
GPSHPRLDPE EIQMADYISK NVPATDHVIR REAETTFSGS HSCSPSHHCS TATPTSSHRH
       550        560        570        580        590        600
ESHTWSLERS ESLTSDSQSG IMLSSVGTSK CNSPACVEAR ARRAAAYSQE ERRRAAMPPY
       610        620        630        640        650        660
HDSIDSLRDS PHSERYVSAL TTPARLSPVD FHYSLATQVP TFEITSPNSA HAVSLPPAAP
       670        680        690        700        710        720
ISYRLAEQQP LLRHPAPPGP GPGPGADMQR SYDSYYYPAA GPGPRRGACA LGGSLGSLPA
       730        740        750        760        770        780
SPFRIPEDDE YETTQECAPP PPPRPRTRGA SRRTSAGPRR WRRSRLNGLA AQRARAARDS
       790        800        810        820        830        840
LSLSSGSGCG SASASDDDAD DADGALAAES TPFLGLRAAH DALRSDSPPL CPAADSRTYY
       850        860
SLDSHSTRAS SRHSRGPPTR AKQDSGPL         10         20         30         40         50         60
MRQVCCSALP PPLEKARCSS YSYSDSSSSS SSNNSSSSTS SRSSSRSSSR SSRGSTTTTS
        70         80         90        100        110        120
SSENSGSNSG SIFRPAAPPE PRPQPQPQPR SPAARRAAAR SRAAAAGGMR RDPAPGSSML
       130        140        150        160        170        180
LFGVSLACYS PSLKSVQDQA YKAPVVVEGK VQGLAPAGGS SSNSTREPPA SGRVALVKVL
       190        200        210        220        230        240
DKWPLRSGGL QREQVISVGS CAPLERNQRY IFFLEPTEQP LVFKTAFAPV DPNGKNIKKE
       250        260        270        280        290        300
VGKILCTDCA TRPKLKKMKS QTGEVGEKQS LKCEAAAGNP QPSYRWFKDG KELNRSRDIR
       310        320        330        340        350        360
IKYGNGRKNS RLQFNKVKVE DAGEYVCEAE NILGKDTVRG RLHVNSVSTT LSSWSGHARK
       370        380        390        400        410        420
CNETAKSYCV NGGVCYYIEG INQLSCKCPN GFFGQRCLEK LPLRLYMPDP KQKHLGFELK
       430        440        450        460        470        480
EAEELYQKRV LTITGICVAL LVVGIVCVVA YCKTKKQRRQ MHHHLRQNMC PAHQNRSLAN
       490        500        510        520        530        540
GPSHPRLDPE EIQMADYISK NVPATDHVIR REAETTFSGS HSCSPSHHCS TATPTSSHRH
       550        560        570        580        590        600
ESHTWSLERS ESLTSDSQSG IMLSSVGTSK CNSPACVEAR ARRAAAYSQE ERRRAAMPPY
       610        620        630        640        650        660
HDSIDSLRDS PHSERYVSAL TTPARLSPVD FHYSLATQVP TFEITSPNSA HAVSLPPAAP
       670        680        690        700        710        720
ISYRLAEQQP LLRHPAPPGP GPGPGADMQR SYDSYYYPAA GPGPRRGACA LGGSLGSLPA
       730        740        750        760        770        780
SPFRIPEDDE YETTQECAPP PPPRPRTRGA SRRTSAGPRR WRRSRLNGLA AQRARAARDS
       790        800        810        820        830        840
LSLSSGSGCG SASASDDDAD DADGALAAES TPFLGLRAAH DALRSDSPPL CPAADSRTYY
       850        860
SLDSHSTRAS SRHSRGPPTR AKQDSGPL         10         20         30         40         50         60
MRQVCCSALP PPLEKARCSS YSYSDSSSSS SSNNSSSSTS SRSSSRSSSR SSRGSTTTTS
        70         80         90        100        110        120
SSENSGSNSG SIFRPAAPPE PRPQPQPQPR SPAARRAAAR SRAAAAGGMR RDPAPGSSML
       130        140        150        160        170        180
LFGVSLACYS PSLKSVQDQA YKAPVVVEGK VQGLAPAGGS SSNSTREPPA SGRVALVKVL
       190        200        210        220        230        240
DKWPLRSGGL QREQVISVGS CAPLERNQRY IFFLEPTEQP LVFKTAFAPV DPNGKNIKKE
       250        260        270        280        290        300
VGKILCTDCA TRPKLKKMKS QTGEVGEKQS LKCEAAAGNP QPSYRWFKDG KELNRSRDIR
       310        320        330        340        350        360
IKYGNGRKNS RLQFNKVKVE DAGEYVCEAE NILGKDTVRG RLHVNSVSTT LSSWSGHARK
       370        380        390        400        410        420
CNETAKSYCV NGGVCYYIEG INQLSCKCPN GFFGQRCLEK LPLRLYMPDP KQKHLGFELK
       430        440        450        460        470        480
EAEELYQKRV LTITGICVAL LVVGIVCVVA YCKTKKQRRQ MHHHLRQNMC PAHQNRSLAN
       490        500        510        520        530        540
GPSHPRLDPE EIQMADYISK NVPATDHVIR REAETTFSGS HSCSPSHHCS TATPTSSHRH
       550        560        570        580        590        600
ESHTWSLERS ESLTSDSQSG IMLSSVGTSK CNSPACVEAR ARRAAAYSQE ERRRAAMPPY
       610        620        630        640        650        660
HDSIDSLRDS PHSERYVSAL TTPARLSPVD FHYSLATQVP TFEITSPNSA HAVSLPPAAP
       670        680        690        700        710        720
ISYRLAEQQP LLRHPAPPGP GPGPGADMQR SYDSYYYPAA GPGPRRGACA LGGSLGSLPA
       730        740        750        760        770        780
SPFRIPEDDE YETTQECAPP PPPRPRTRGA SRRTSAGPRR WRRSRLNGLA AQRARAARDS
       790        800        810        820        830        840
LSLSSGSGCG SASASDDDAD DADGALAAES TPFLGLRAAH DALRSDSPPL CPAADSRTYY
       850        860
SLDSHSTRAS SRHSRGPPTR AKQDSGPL         10         20         30         40         50         60
MRQVCCSALP PPLEKARCSS YSYSDSSSSS SSNNSSSSTS SRSSSRSSSR SSRGSTTTTS
        70         80         90        100        110        120
SSENSGSNSG SIFRPAAPPE PRPQPQPQPR SPAARRAAAR SRAAAAGGMR RDPAPGSSML
       130        140        150        160        170        180
LFGVSLACYS PSLKSVQDQA YKAPVVVEGK VQGLAPAGGS SSNSTREPPA SGRVALVKVL
       190        200        210        220        230        240
DKWPLRSGGL QREQVISVGS CAPLERNQRY IFFLEPTEQP LVFKTAFAPV DPNGKNIKKE
       250        260        270        280        290        300
VGKILCTDCA TRPKLKKMKS QTGEVGEKQS LKCEAAAGNP QPSYRWFKDG KELNRSRDIR
       310        320        330        340        350        360
IKYGNGRKNS RLQFNKVKVE DAGEYVCEAE NILGKDTVRG RLHVNSVSTT LSSWSGHARK
       370        380        390        400        410        420
CNETAKSYCV NGGVCYYIEG INQLSCKCPN GFFGQRCLEK LPLRLYMPDP KQKHLGFELK
       430        440        450        460        470        480
EAEELYQKRV LTITGICVAL LVVGIVCVVA YCKTKKQRRQ MHHHLRQNMC PAHQNRSLAN
       490        500        510        520        530        540
GPSHPRLDPE EIQMADYISK NVPATDHVIR REAETTFSGS HSCSPSHHCS TATPTSSHRH
       550        560        570        580        590        600
ESHTWSLERS ESLTSDSQSG IMLSSVGTSK CNSPACVEAR ARRAAAYSQE ERRRAAMPPY
       610        620        630        640        650        660
HDSIDSLRDS PHSERYVSAL TTPARLSPVD FHYSLATQVP TFEITSPNSA HAVSLPPAAP
       670        680        690        700        710        720
ISYRLAEQQP LLRHPAPPGP GPGPGADMQR SYDSYYYPAA GPGPRRGACA LGGSLGSLPA
       730        740        750        760        770        780
SPFRIPEDDE YETTQECAPP PPPRPRTRGA SRRTSAGPRR WRRSRLNGLA AQRARAARDS
       790        800        810        820        830        840
LSLSSGSGCG SASASDDDAD DADGALAAES TPFLGLRAAH DALRSDSPPL CPAADSRTYY
       850        860
SLDSHSTRAS SRHSRGPPTR AKQDSGPL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O35569-1-unknown	MRQVCC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt193111
O35569-1-unknown	MRQVCC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt193112
O35569-1-unknown	MRQVCC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt193113
O35569-1-unknown	MRQVCC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt193114
O35569-1-unknown	MRQVCC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt193115
O35569-109-unknown	MRRDPA...	109	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt193116
O35569-109-unknown	MRRDPA...	109	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt193942
O35569-109-unknown	MRRDPA...	109	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt193943
O35569-109-unknown	MRRDPA...	109	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt193944
O35569-109-unknown	MRRDPA...	109	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt193945
O35569-109-unknown	MRRDPA...	109	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt193946
O35569-128-unknown	CYSPSL...	128	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O35569-128-unknown	CYSPSL...	128	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197377
O35569-128-unknown	CYSPSL...	128	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197378
O35569-128-unknown	CYSPSL...	128	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197379
O35569-128-unknown	CYSPSL...	128	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197380
O35569-128-unknown	CYSPSL...	128	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197381
O35569-128-unknown	CYSPSL...	128	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197382

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ELYQKR	428	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DSGPL	868	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DSGPL	868	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153062
...DSGPL	868	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153059
...DSGPL	868	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153057
...DSGPL	868	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153058

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)