TopFIND 4.0

O35732: CASP8 and FADD-like apoptosis regulator

General Information

Protein names
- CASP8 and FADD-like apoptosis regulator
- Caspase homolog
- CASH
- Caspase-eight-related protein
- Casper
- Caspase-like apoptosis regulatory protein
- CLARP
- Cellular FLICE-like inhibitory protein
- c-FLIP
- FADD-like antiapoptotic molecule 1
- FLAME-1
- Inhibitor of FLICE
- I-FLICE
- MACH-related inducer of toxicity
- MRIT
- Usurpin
- CASP8 and FADD-like apoptosis regulator subunit p43
- CASP8 and FADD-like apoptosis regulator subunit p12
Gene names Cflar
Organism Mus musculus
Protease Family
Protease ID C14.974
Chromosome location
UniProt ID O35732

2

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAQSPVSAEV IHQVEECLDE DEKEMMLFLC RDVTENLAAP NVRDLLDSLS ERGQLSFATL 
        70         80         90        100        110        120 
AELLYRVRRF DLLKRILKTD KATVEDHLRR NPHLVSDYRV LLMEIGESLD QNDVSSLVFL 
       130        140        150        160        170        180 
TRDYTGRGKI AKDKSFLDLV IELEKLNLIA SDQLNLLEKC LKNIHRIDLN TKIQKYTQSS 
       190        200        210        220        230        240 
QGARSNMNTL QASLPKLSIK YNSRLQNGRS KEPRFVEYRD SQRTLVKTSI QESGAFLPPH 
       250        260        270        280        290        300 
IREETYRMQS KPLGICLIID CIGNDTKYLQ ETFTSLGYHI QLFLFPKSHD ITQIVRRYAS 
       310        320        330        340        350        360 
MAQHQDYDSF ACVLVSLGGS QSMMGRDQVH SGFSLDHVKN MFTGDTCPSL RGKPKLFFIQ 
       370        380        390        400        410        420 
NYESLGSQLE DSSLEVDGPS IKNVDSKPLQ PRHCTTHPEA DIFWSLCTAD VSHLEKPSSS 
       430        440        450        460        470        480 
SSVYLQKLSQ QLKQGRRRPL VDLHVELMDK VYAWNSGVSS KEKYSLSLQH TLRKKLILAP 
   
T

Isoforms

- Isoform 2 of CASP8 and FADD-like apoptosis regulator - Isoform 2 of CASP8 and FADD-like apoptosis regulator

Sequence View

        10         20         30         40         50         60 
MAQSPVSAEV IHQVEECLDE DEKEMMLFLC RDVTENLAAP NVRDLLDSLS ERGQLSFATL 
        70         80         90        100        110        120 
AELLYRVRRF DLLKRILKTD KATVEDHLRR NPHLVSDYRV LLMEIGESLD QNDVSSLVFL 
       130        140        150        160        170        180 
TRDYTGRGKI AKDKSFLDLV IELEKLNLIA SDQLNLLEKC LKNIHRIDLN TKIQKYTQSS 
       190        200        210        220        230        240 
QGARSNMNTL QASLPKLSIK YNSRLQNGRS KEPRFVEYRD SQRTLVKTSI QESGAFLPPH 
       250        260        270        280        290        300 
IREETYRMQS KPLGICLIID CIGNDTKYLQ ETFTSLGYHI QLFLFPKSHD ITQIVRRYAS 
       310        320        330        340        350        360 
MAQHQDYDSF ACVLVSLGGS QSMMGRDQVH SGFSLDHVKN MFTGDTCPSL RGKPKLFFIQ 
       370        380        390        400        410        420 
NYESLGSQLE DSSLEVDGPS IKNVDSKPLQ PRHCTTHPEA DIFWSLCTAD VSHLEKPSSS 
       430        440        450        460        470        480 
SSVYLQKLSQ QLKQGRRRPL VDLHVELMDK VYAWNSGVSS KEKYSLSLQH TLRKKLILAP 
   
T         10         20         30         40         50         60 
MAQSPVSAEV IHQVEECLDE DEKEMMLFLC RDVTENLAAP NVRDLLDSLS ERGQLSFATL 
        70         80         90        100        110        120 
AELLYRVRRF DLLKRILKTD KATVEDHLRR NPHLVSDYRV LLMEIGESLD QNDVSSLVFL 
       130        140        150        160        170        180 
TRDYTGRGKI AKDKSFLDLV IELEKLNLIA SDQLNLLEKC LKNIHRIDLN TKIQKYTQSS 
       190        200        210        220        230        240 
QGARSNMNTL QASLPKLSIK YNSRLQNGRS KEPRFVEYRD SQRTLVKTSI QESGAFLPPH 
       250        260        270        280        290        300 
IREETYRMQS KPLGICLIID CIGNDTKYLQ ETFTSLGYHI QLFLFPKSHD ITQIVRRYAS 
       310        320        330        340        350        360 
MAQHQDYDSF ACVLVSLGGS QSMMGRDQVH SGFSLDHVKN MFTGDTCPSL RGKPKLFFIQ 
       370        380        390        400        410        420 
NYESLGSQLE DSSLEVDGPS IKNVDSKPLQ PRHCTTHPEA DIFWSLCTAD VSHLEKPSSS 
       430        440        450        460        470        480 
SSVYLQKLSQ QLKQGRRRPL VDLHVELMDK VYAWNSGVSS KEKYSLSLQH TLRKKLILAP 
   
T



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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...VDGPSI 380 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...PT 484 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)