O43166: Signal-induced proliferation-associated 1-like protein 1
| Protein names | - Signal-induced proliferation-associated 1-like protein 1 - SIPA1-like protein 1 - High-risk human papilloma viruses E6 oncoproteins targeted protein 1 - E6-targeted protein 1 |
|---|---|
| Gene names | SIPA1L1 |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | O43166 |
3
N-termini
3
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MTSLKRSQTE RPLATDRASV VGTDGTPKVH TDDFYMRRFR SQNGSLGSSV MAPVGPPRSE
70 80 90 100 110 120
GSHHITSTPG VPKMGVRARI ADWPPRKENI KESSRSSQEI ETSSCLDSLS SKSSPVSQGS
130 140 150 160 170 180
SVSLNSNDSA MLKSIQNTLK NKTRPSENMD SRFLMPEAYP SSPRKALRRI RQRSNSDITI
190 200 210 220 230 240
SELDVDSFDE CISPTYKTGP SLHREYGSTS SIDKQGTSGE SFFDLLKGYK DDKSDRGPTP
250 260 270 280 290 300
TKLSDFLITG GGKGSGFSLD VIDGPISQRE NLRLFKEREK PLKRRSKSET GDSSIFRKLR
310 320 330 340 350 360
NAKGEELGKS SDLEDNRSED SVRPWTCPKC FAHYDVQSIL FDLNEAIMNR HNVIKRRNTT
370 380 390 400 410 420
TGASAAAVAS LVSGPLSHSA SFSSPMGSTE DLNSKGSLSM DQGDDKSNEL VMSCPYFRNE
430 440 450 460 470 480
IGGEGERKIS LSKSNSGSFS GCESASFEST LSSHCTNAGV AVLEVPKENL VLHLDRVKRY
490 500 510 520 530 540
IVEHVDLGAY YYRKFFYQKE HWNYFGADEN LGPVAVSIRR EKPDEMKENG SPYNYRIIFR
550 560 570 580 590 600
TSELMTLRGS VLEDAIPSTA KHSTARGLPL KEVLEHVVPE LNVQCLRLAF NTPKVTEQLM
610 620 630 640 650 660
KLDEQGLNYQ QKVGIMYCKA GQSTEEEMYN NESAGPAFEE FLQLLGERVR LKGFEKYRAQ
670 680 690 700 710 720
LDTKTDSTGT HSLYTTYKDY EIMFHVSTML PYTPNNKQQL LRKRHIGNDI VTIVFQEPGA
730 740 750 760 770 780
QPFSPKNIRS HFQHVFVIVR VHNPCSDSVC YSVAVTRSRD VPSFGPPIPK GVTFPKSNVF
790 800 810 820 830 840
RDFLLAKVIN AENAAHKSEK FRAMATRTRQ EYLKDLAEKN VTNTPIDPSG KFPFISLASK
850 860 870 880 890 900
KKEKSKPYPG AELSSMGAIV WAVRAEDYNK AMELDCLLGI SNEFIVLIEQ ETKSVVFNCS
910 920 930 940 950 960
CRDVIGWTST DTSLKIFYER GECVSVGSFI NIEEIKEIVK RLQFVSKGCE SVEMTLRRNG
970 980 990 1000 1010 1020
LGQLGFHVNY EGIVADVEPY GYAWQAGLRQ GSRLVEICKV AVATLSHEQM IDLLRTSVTV
1030 1040 1050 1060 1070 1080
KVVIIPPHDD CTPRRSCSET YRMPVMEYKM NEGVSYEFKF PFRNNNKWQR NASKGPHSPQ
1090 1100 1110 1120 1130 1140
VPSQVQSPMT SRLNAGKGDG KMPPPERAAN IPRSISSDGR PLERRLSPGS DIYVTVSSMA
1150 1160 1170 1180 1190 1200
LARSQCRNSP SNLSSSSDTG SVGGTYRQKS MPEGFGVSRR SPASIDRQNT QSDIGGSGKS
1210 1220 1230 1240 1250 1260
TPSWQRSEDS IADQMAYSYR GPQDFNSFVL EQHEYTEPTC HLPAVSKVLP AFRESPSGRL
1270 1280 1290 1300 1310 1320
MRQDPVVHLS PNKQGHSDSH YSSHSSSNTL SSNASSAHSD EKWYDGDRTE SELNSYNYLQ
1330 1340 1350 1360 1370 1380
GTSADSGIDT TSYGPSHGST ASLGAATSSP RSGPGKEKVA PLWHSSSEVI SMADRTLETE
1390 1400 1410 1420 1430 1440
SHGLDRKTES SLSLDIHSKS QAGSTPLTRE NSTFSINDAA SHTSTMSSRH SASPVVFTSA
1450 1460 1470 1480 1490 1500
RSSPKEELHP AAPSQLAPSF SSSSSSSSGP RSFYPRQGAT SKYLIGWKKP EGTINSVGFM
1510 1520 1530 1540 1550 1560
DTRKRHQSDG NEIAHTRLRA STRDLRASPK PTSKSTIEED LKKLIDLESP TPESQKSFKF
1570 1580 1590 1600 1610 1620
HALSSPQSPF PSTPTSRRAL HRTLSDESIY NSQREHFFTS RASLLDQALP NDVLFSSTYP
1630 1640 1650 1660 1670 1680
SLPKSLPLRR PSYTLGMKSL HGEFSASDSS LTDIQETRRQ PMPDPGLMPL PDTAADLDWS
1690 1700 1710 1720 1730 1740
NLVDAAKAYE VQRASFFAAS DENHRPLSAA SNSDQLEDQA LAQMKPYSSS KDSSPTLASK
1750 1760 1770 1780 1790 1800
VDQLEGMLKM LREDLKKEKE DKAHLQAEVQ HLREDNLRLQ EESQNASDKL KKFTEWVFNT
IDMS
Isoforms
- Isoform 2 of Signal-induced proliferation-associated 1-like protein 1 - Isoform 3 of Signal-induced proliferation-associated 1-like protein 1Sequence View
10 20 30 40 50 60
MTSLKRSQTE RPLATDRASV VGTDGTPKVH TDDFYMRRFR SQNGSLGSSV MAPVGPPRSE
70 80 90 100 110 120
GSHHITSTPG VPKMGVRARI ADWPPRKENI KESSRSSQEI ETSSCLDSLS SKSSPVSQGS
130 140 150 160 170 180
SVSLNSNDSA MLKSIQNTLK NKTRPSENMD SRFLMPEAYP SSPRKALRRI RQRSNSDITI
190 200 210 220 230 240
SELDVDSFDE CISPTYKTGP SLHREYGSTS SIDKQGTSGE SFFDLLKGYK DDKSDRGPTP
250 260 270 280 290 300
TKLSDFLITG GGKGSGFSLD VIDGPISQRE NLRLFKEREK PLKRRSKSET GDSSIFRKLR
310 320 330 340 350 360
NAKGEELGKS SDLEDNRSED SVRPWTCPKC FAHYDVQSIL FDLNEAIMNR HNVIKRRNTT
370 380 390 400 410 420
TGASAAAVAS LVSGPLSHSA SFSSPMGSTE DLNSKGSLSM DQGDDKSNEL VMSCPYFRNE
430 440 450 460 470 480
IGGEGERKIS LSKSNSGSFS GCESASFEST LSSHCTNAGV AVLEVPKENL VLHLDRVKRY
490 500 510 520 530 540
IVEHVDLGAY YYRKFFYQKE HWNYFGADEN LGPVAVSIRR EKPDEMKENG SPYNYRIIFR
550 560 570 580 590 600
TSELMTLRGS VLEDAIPSTA KHSTARGLPL KEVLEHVVPE LNVQCLRLAF NTPKVTEQLM
610 620 630 640 650 660
KLDEQGLNYQ QKVGIMYCKA GQSTEEEMYN NESAGPAFEE FLQLLGERVR LKGFEKYRAQ
670 680 690 700 710 720
LDTKTDSTGT HSLYTTYKDY EIMFHVSTML PYTPNNKQQL LRKRHIGNDI VTIVFQEPGA
730 740 750 760 770 780
QPFSPKNIRS HFQHVFVIVR VHNPCSDSVC YSVAVTRSRD VPSFGPPIPK GVTFPKSNVF
790 800 810 820 830 840
RDFLLAKVIN AENAAHKSEK FRAMATRTRQ EYLKDLAEKN VTNTPIDPSG KFPFISLASK
850 860 870 880 890 900
KKEKSKPYPG AELSSMGAIV WAVRAEDYNK AMELDCLLGI SNEFIVLIEQ ETKSVVFNCS
910 920 930 940 950 960
CRDVIGWTST DTSLKIFYER GECVSVGSFI NIEEIKEIVK RLQFVSKGCE SVEMTLRRNG
970 980 990 1000 1010 1020
LGQLGFHVNY EGIVADVEPY GYAWQAGLRQ GSRLVEICKV AVATLSHEQM IDLLRTSVTV
1030 1040 1050 1060 1070 1080
KVVIIPPHDD CTPRRSCSET YRMPVMEYKM NEGVSYEFKF PFRNNNKWQR NASKGPHSPQ
1090 1100 1110 1120 1130 1140
VPSQVQSPMT SRLNAGKGDG KMPPPERAAN IPRSISSDGR PLERRLSPGS DIYVTVSSMA
1150 1160 1170 1180 1190 1200
LARSQCRNSP SNLSSSSDTG SVGGTYRQKS MPEGFGVSRR SPASIDRQNT QSDIGGSGKS
1210 1220 1230 1240 1250 1260
TPSWQRSEDS IADQMAYSYR GPQDFNSFVL EQHEYTEPTC HLPAVSKVLP AFRESPSGRL
1270 1280 1290 1300 1310 1320
MRQDPVVHLS PNKQGHSDSH YSSHSSSNTL SSNASSAHSD EKWYDGDRTE SELNSYNYLQ
1330 1340 1350 1360 1370 1380
GTSADSGIDT TSYGPSHGST ASLGAATSSP RSGPGKEKVA PLWHSSSEVI SMADRTLETE
1390 1400 1410 1420 1430 1440
SHGLDRKTES SLSLDIHSKS QAGSTPLTRE NSTFSINDAA SHTSTMSSRH SASPVVFTSA
1450 1460 1470 1480 1490 1500
RSSPKEELHP AAPSQLAPSF SSSSSSSSGP RSFYPRQGAT SKYLIGWKKP EGTINSVGFM
1510 1520 1530 1540 1550 1560
DTRKRHQSDG NEIAHTRLRA STRDLRASPK PTSKSTIEED LKKLIDLESP TPESQKSFKF
1570 1580 1590 1600 1610 1620
HALSSPQSPF PSTPTSRRAL HRTLSDESIY NSQREHFFTS RASLLDQALP NDVLFSSTYP
1630 1640 1650 1660 1670 1680
SLPKSLPLRR PSYTLGMKSL HGEFSASDSS LTDIQETRRQ PMPDPGLMPL PDTAADLDWS
1690 1700 1710 1720 1730 1740
NLVDAAKAYE VQRASFFAAS DENHRPLSAA SNSDQLEDQA LAQMKPYSSS KDSSPTLASK
1750 1760 1770 1780 1790 1800
VDQLEGMLKM LREDLKKEKE DKAHLQAEVQ HLREDNLRLQ EESQNASDKL KKFTEWVFNT
IDMS
10 20 30 40 50 60
MTSLKRSQTE RPLATDRASV VGTDGTPKVH TDDFYMRRFR SQNGSLGSSV MAPVGPPRSE
70 80 90 100 110 120
GSHHITSTPG VPKMGVRARI ADWPPRKENI KESSRSSQEI ETSSCLDSLS SKSSPVSQGS
130 140 150 160 170 180
SVSLNSNDSA MLKSIQNTLK NKTRPSENMD SRFLMPEAYP SSPRKALRRI RQRSNSDITI
190 200 210 220 230 240
SELDVDSFDE CISPTYKTGP SLHREYGSTS SIDKQGTSGE SFFDLLKGYK DDKSDRGPTP
250 260 270 280 290 300
TKLSDFLITG GGKGSGFSLD VIDGPISQRE NLRLFKEREK PLKRRSKSET GDSSIFRKLR
310 320 330 340 350 360
NAKGEELGKS SDLEDNRSED SVRPWTCPKC FAHYDVQSIL FDLNEAIMNR HNVIKRRNTT
370 380 390 400 410 420
TGASAAAVAS LVSGPLSHSA SFSSPMGSTE DLNSKGSLSM DQGDDKSNEL VMSCPYFRNE
430 440 450 460 470 480
IGGEGERKIS LSKSNSGSFS GCESASFEST LSSHCTNAGV AVLEVPKENL VLHLDRVKRY
490 500 510 520 530 540
IVEHVDLGAY YYRKFFYQKE HWNYFGADEN LGPVAVSIRR EKPDEMKENG SPYNYRIIFR
550 560 570 580 590 600
TSELMTLRGS VLEDAIPSTA KHSTARGLPL KEVLEHVVPE LNVQCLRLAF NTPKVTEQLM
610 620 630 640 650 660
KLDEQGLNYQ QKVGIMYCKA GQSTEEEMYN NESAGPAFEE FLQLLGERVR LKGFEKYRAQ
670 680 690 700 710 720
LDTKTDSTGT HSLYTTYKDY EIMFHVSTML PYTPNNKQQL LRKRHIGNDI VTIVFQEPGA
730 740 750 760 770 780
QPFSPKNIRS HFQHVFVIVR VHNPCSDSVC YSVAVTRSRD VPSFGPPIPK GVTFPKSNVF
790 800 810 820 830 840
RDFLLAKVIN AENAAHKSEK FRAMATRTRQ EYLKDLAEKN VTNTPIDPSG KFPFISLASK
850 860 870 880 890 900
KKEKSKPYPG AELSSMGAIV WAVRAEDYNK AMELDCLLGI SNEFIVLIEQ ETKSVVFNCS
910 920 930 940 950 960
CRDVIGWTST DTSLKIFYER GECVSVGSFI NIEEIKEIVK RLQFVSKGCE SVEMTLRRNG
970 980 990 1000 1010 1020
LGQLGFHVNY EGIVADVEPY GYAWQAGLRQ GSRLVEICKV AVATLSHEQM IDLLRTSVTV
1030 1040 1050 1060 1070 1080
KVVIIPPHDD CTPRRSCSET YRMPVMEYKM NEGVSYEFKF PFRNNNKWQR NASKGPHSPQ
1090 1100 1110 1120 1130 1140
VPSQVQSPMT SRLNAGKGDG KMPPPERAAN IPRSISSDGR PLERRLSPGS DIYVTVSSMA
1150 1160 1170 1180 1190 1200
LARSQCRNSP SNLSSSSDTG SVGGTYRQKS MPEGFGVSRR SPASIDRQNT QSDIGGSGKS
1210 1220 1230 1240 1250 1260
TPSWQRSEDS IADQMAYSYR GPQDFNSFVL EQHEYTEPTC HLPAVSKVLP AFRESPSGRL
1270 1280 1290 1300 1310 1320
MRQDPVVHLS PNKQGHSDSH YSSHSSSNTL SSNASSAHSD EKWYDGDRTE SELNSYNYLQ
1330 1340 1350 1360 1370 1380
GTSADSGIDT TSYGPSHGST ASLGAATSSP RSGPGKEKVA PLWHSSSEVI SMADRTLETE
1390 1400 1410 1420 1430 1440
SHGLDRKTES SLSLDIHSKS QAGSTPLTRE NSTFSINDAA SHTSTMSSRH SASPVVFTSA
1450 1460 1470 1480 1490 1500
RSSPKEELHP AAPSQLAPSF SSSSSSSSGP RSFYPRQGAT SKYLIGWKKP EGTINSVGFM
1510 1520 1530 1540 1550 1560
DTRKRHQSDG NEIAHTRLRA STRDLRASPK PTSKSTIEED LKKLIDLESP TPESQKSFKF
1570 1580 1590 1600 1610 1620
HALSSPQSPF PSTPTSRRAL HRTLSDESIY NSQREHFFTS RASLLDQALP NDVLFSSTYP
1630 1640 1650 1660 1670 1680
SLPKSLPLRR PSYTLGMKSL HGEFSASDSS LTDIQETRRQ PMPDPGLMPL PDTAADLDWS
1690 1700 1710 1720 1730 1740
NLVDAAKAYE VQRASFFAAS DENHRPLSAA SNSDQLEDQA LAQMKPYSSS KDSSPTLASK
1750 1760 1770 1780 1790 1800
VDQLEGMLKM LREDLKKEKE DKAHLQAEVQ HLREDNLRLQ EESQNASDKL KKFTEWVFNT
IDMS
Protein Neighborhood
Domains & Features
3 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| O43166-1-unknown | MTSLKR... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| O43166-1-unknown | MTSLKR... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt89671 | |||
| O43166-1-unknown | MTSLKR... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt89672 | |||
| O43166-500-unknown | EHWNYF... | 500 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000452450 | |||
| O43166-500-unknown | EHWNYF... | 500 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt131115 | |||
| O43166-500-unknown | EHWNYF... | 500 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt131116 | |||
| O43166-526-unknown | MKENGS... | 526 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000440682 | |||
| O43166-526-unknown | MKENGS... | 526 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt131112 | |||
| O43166-526-unknown | MKENGS... | 526 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt131113 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...KVHTDD | 32 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000452080 | |||
| ...KVHTDD | 32 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt111122 | |||
| ...KVHTDD | 32 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt111123 | |||
| ...VHNPCS | 745 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000452450 | |||
| ...VHNPCS | 745 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt111125 | |||
| ...VHNPCS | 745 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt111126 | |||
| ...TIDMS | 1804 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...TIDMS | 1804 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt85290 | |||
| ...TIDMS | 1804 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt85289 |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|