O43272: Proline dehydrogenase 1, mitochondrial {ECO:0000305}

General Information

Protein names	- Proline dehydrogenase 1, mitochondrial {ECO:0000305} - 1.5.5.2 {ECO:0000269\|PubMed:15662599} - Proline oxidase - Proline oxidase 2 - p53-induced gene 6 protein
Gene names	PRODH
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O43272

3 N-termini

3 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Proline dehydrogenase 1, mitochondrial - Isoform 3 of Proline dehydrogenase 1, mitochondrial

Sequence View

        10         20         30         40         50         60
MALRRALPAL RPCIPRFVQL STAPASREQP AAGPAAVPGG GSATAVRPPV PAVDFGNAQE
        70         80         90        100        110        120
AYRSRRTWEL ARSLLVLRLC AWPALLARHE QLLYVSRKLL GQRLFNKLMK MTFYGHFVAG
       130        140        150        160        170        180
EDQESIQPLL RHYRAFGVSA ILDYGVEEDL SPEEAEHKEM ESCTSAAERD GSGTNKRDKQ
       190        200        210        220        230        240
YQAHRAFGDR RNGVISARTY FYANEAKCDS HMETFLRCIE ASGRVSDDGF IAIKLTALGR
       250        260        270        280        290        300
PQFLLQFSEV LAKWRCFFHQ MAVEQGQAGL AAMDTKLEVA VLQESVAKLG IASRAEIEDW
       310        320        330        340        350        360
FTAETLGVSG TMDLLDWSSL IDSRTKLSKH LVVPNAQTGQ LEPLLSRFTE EEELQMTRML
       370        380        390        400        410        420
QRMDVLAKKA TEMGVRLMVD AEQTYFQPAI SRLTLEMQRK FNVEKPLIFN TYQCYLKDAY
       430        440        450        460        470        480
DNVTLDVELA RREGWCFGAK LVRGAYLAQE RARAAEIGYE DPINPTYEAT NAMYHRCLDY
       490        500        510        520        530        540
VLEELKHNAK AKVMVASHNE DTVRFALRRM EELGLHPADH QVYFGQLLGM CDQISFPLGQ
       550        560        570        580        590        600
AGYPVYKYVP YGPVMEVLPY LSRRALENSS LMKGTHRERQ LLWLELLRRL RTGNLFHRPA

        10         20         30         40         50         60
MALRRALPAL RPCIPRFVQL STAPASREQP AAGPAAVPGG GSATAVRPPV PAVDFGNAQE
        70         80         90        100        110        120
AYRSRRTWEL ARSLLVLRLC AWPALLARHE QLLYVSRKLL GQRLFNKLMK MTFYGHFVAG
       130        140        150        160        170        180
EDQESIQPLL RHYRAFGVSA ILDYGVEEDL SPEEAEHKEM ESCTSAAERD GSGTNKRDKQ
       190        200        210        220        230        240
YQAHRAFGDR RNGVISARTY FYANEAKCDS HMETFLRCIE ASGRVSDDGF IAIKLTALGR
       250        260        270        280        290        300
PQFLLQFSEV LAKWRCFFHQ MAVEQGQAGL AAMDTKLEVA VLQESVAKLG IASRAEIEDW
       310        320        330        340        350        360
FTAETLGVSG TMDLLDWSSL IDSRTKLSKH LVVPNAQTGQ LEPLLSRFTE EEELQMTRML
       370        380        390        400        410        420
QRMDVLAKKA TEMGVRLMVD AEQTYFQPAI SRLTLEMQRK FNVEKPLIFN TYQCYLKDAY
       430        440        450        460        470        480
DNVTLDVELA RREGWCFGAK LVRGAYLAQE RARAAEIGYE DPINPTYEAT NAMYHRCLDY
       490        500        510        520        530        540
VLEELKHNAK AKVMVASHNE DTVRFALRRM EELGLHPADH QVYFGQLLGM CDQISFPLGQ
       550        560        570        580        590        600
AGYPVYKYVP YGPVMEVLPY LSRRALENSS LMKGTHRERQ LLWLELLRRL RTGNLFHRPA

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O43272-0-unknown	AMALRR...	0	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O43272-109-unknown	MKMTFY...	109	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86232
O43272-109-unknown	MKMTFY...	109	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000410805
O43272-109-unknown	MKMTFY...	109	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000334726
O43272-160-unknown	MESCTS...	160	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000396806
O43272-160-unknown	MESCTS...	160	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt130990

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GIASRA	294	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000396806
...GIASRA	294	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt110860
...LIDSRT	324	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000409742
...LIDSRT	324	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt110857
...FHRPA	600	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...FHRPA	600	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81850

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)