TopFIND 4.0

O43291: Kunitz-type protease inhibitor 2

General Information

Protein names
- Kunitz-type protease inhibitor 2
- Hepatocyte growth factor activator inhibitor type 2
- HAI-2
- Placental bikunin
Gene names SPINT2
Organism Homo sapiens
Protease Family
Protease ID I02.009
Chromosome location
UniProt ID O43291

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAQLCGLRRS RAFLALLGSL LLSGVLAADR ERSIHDFCLV SKVVGRCRAS MPRWWYNVTD 
        70         80         90        100        110        120 
GSCQLFVYGG CDGNSNNYLT KEECLKKCAT VTENATGDLA TSRNAADSSV PSAPRRQDSE 
       130        140        150        160        170        180 
DHSSDMFNYE EYCTANAVTG PCRASFPRWY FDVERNSCNN FIYGGCRGNK NSYRSEEACM 
       190        200        210        220        230        240 
LRCFRQQENP PLPLGSKVVV LAGLFVMVLI LFLGASMVYL IRVARRNQER ALRTVWSSGD 
       250    
DKEQLVKNTY VL

Isoforms

- Isoform 2 of Kunitz-type protease inhibitor 2

Sequence View

        10         20         30         40         50         60 
MAQLCGLRRS RAFLALLGSL LLSGVLAADR ERSIHDFCLV SKVVGRCRAS MPRWWYNVTD 
        70         80         90        100        110        120 
GSCQLFVYGG CDGNSNNYLT KEECLKKCAT VTENATGDLA TSRNAADSSV PSAPRRQDSE 
       130        140        150        160        170        180 
DHSSDMFNYE EYCTANAVTG PCRASFPRWY FDVERNSCNN FIYGGCRGNK NSYRSEEACM 
       190        200        210        220        230        240 
LRCFRQQENP PLPLGSKVVV LAGLFVMVLI LFLGASMVYL IRVARRNQER ALRTVWSSGD 
       250    
DKEQLVKNTY VL



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Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    O43291-1-unknown MAQLCG... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt90473
    O43291-28-unknown ADRERS... 28 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...NTYVL 252 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...NTYVL 252 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt86091

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)