TopFIND 4.0

O43353: Receptor-interacting serine/threonine-protein kinase 2

General Information

Protein names
- Receptor-interacting serine/threonine-protein kinase 2
- 2.7.11.1
- CARD-containing interleukin-1 beta-converting enzyme-associated kinase
- CARD-containing IL-1 beta ICE-kinase
- RIP-like-interacting CLARP kinase
- Receptor-interacting protein 2
- RIP-2
- Tyrosine-protein kinase RIPK2
- 2.7.10.2
Gene names RIPK2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID O43353

2

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MNGEAICSAL PTIPYHKLAD LRYLSRGASG TVSSARHADW RVQVAVKHLH IHTPLLDSER 
        70         80         90        100        110        120 
KDVLREAEIL HKARFSYILP ILGICNEPEF LGIVTEYMPN GSLNELLHRK TEYPDVAWPL 
       130        140        150        160        170        180 
RFRILHEIAL GVNYLHNMTP PLLHHDLKTQ NILLDNEFHV KIADFGLSKW RMMSLSQSRS 
       190        200        210        220        230        240 
SKSAPEGGTI IYMPPENYEP GQKSRASIKH DIYSYAVITW EVLSRKQPFE DVTNPLQIMY 
       250        260        270        280        290        300 
SVSQGHRPVI NEESLPYDIP HRARMISLIE SGWAQNPDER PSFLKCLIEL EPVLRTFEEI 
       310        320        330        340        350        360 
TFLEAVIQLK KTKLQSVSSA IHLCDKKKME LSLNIPVNHG PQEESCGSSQ LHENSGSPET 
       370        380        390        400        410        420 
SRSLPAPQDN DFLSRKAQDC YFMKLHHCPG NHSWDSTISG SQRAAFCDHK TTPCSSAIIN 
       430        440        450        460        470        480 
PLSTAGNSER LQPGIAQQWI QSKREDIVNQ MTEACLNQSL DALLSRDLIM KEDYELVSTK 
       490        500        510        520        530        540 
PTRTSKVRQL LDTTDIQGEE FAKVIVQKLK DNKQMGLQPY PEILVVSRSP SLNLLQNKSM 
   

Isoforms

- Isoform 2 of Receptor-interacting serine/threonine-protein kinase 2

Sequence View

        10         20         30         40         50         60 
MNGEAICSAL PTIPYHKLAD LRYLSRGASG TVSSARHADW RVQVAVKHLH IHTPLLDSER 
        70         80         90        100        110        120 
KDVLREAEIL HKARFSYILP ILGICNEPEF LGIVTEYMPN GSLNELLHRK TEYPDVAWPL 
       130        140        150        160        170        180 
RFRILHEIAL GVNYLHNMTP PLLHHDLKTQ NILLDNEFHV KIADFGLSKW RMMSLSQSRS 
       190        200        210        220        230        240 
SKSAPEGGTI IYMPPENYEP GQKSRASIKH DIYSYAVITW EVLSRKQPFE DVTNPLQIMY 
       250        260        270        280        290        300 
SVSQGHRPVI NEESLPYDIP HRARMISLIE SGWAQNPDER PSFLKCLIEL EPVLRTFEEI 
       310        320        330        340        350        360 
TFLEAVIQLK KTKLQSVSSA IHLCDKKKME LSLNIPVNHG PQEESCGSSQ LHENSGSPET 
       370        380        390        400        410        420 
SRSLPAPQDN DFLSRKAQDC YFMKLHHCPG NHSWDSTISG SQRAAFCDHK TTPCSSAIIN 
       430        440        450        460        470        480 
PLSTAGNSER LQPGIAQQWI QSKREDIVNQ MTEACLNQSL DALLSRDLIM KEDYELVSTK 
       490        500        510        520        530        540 
PTRTSKVRQL LDTTDIQGEE FAKVIVQKLK DNKQMGLQPY PEILVVSRSP SLNLLQNKSM 
   



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Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


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Biological System:


Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    O43353-1-unknown MNGEAI... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    O43353-138-unknown MTPPLL... 138 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt87782

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)