TopFIND 4.0

O43508: Tumor necrosis factor ligand superfamily member 12

General Information

Protein names
- Tumor necrosis factor ligand superfamily member 12
- APO3 ligand
- TNF-related weak inducer of apoptosis
- TWEAK
- Tumor necrosis factor ligand superfamily member 12, membrane form
- Tumor necrosis factor ligand superfamily member 12, secreted form
Gene names TNFSF12
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID O43508

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAARRSQRRR GRRGEPGTAL LVPLALGLGL ALACLGLLLA VVSLGSRASL SAQEPAQEEL 
        70         80         90        100        110        120 
VAEEDQDPSE LNPQTEESQD PAPFLNRLVR PRRSAPKGRK TRARRAIAAH YEVHPRPGQD 
       130        140        150        160        170        180 
GAQAGVDGTV SGWEEARINS SSPLRYNRQI GEFIVTRAGL YYLYCQVHFD EGKAVYLKLD 
       190        200        210        220        230        240 
LLVDGVLALR CLEEFSATAA SSLGPQLRLC QVSGLLALRP GSSLRIRTLP WAHLKAAPFL 
   
TYFGLFQVH

Isoforms

- Isoform TWE-PRIL of Tumor necrosis factor ligand superfamily member 12

Sequence View

        10         20         30         40         50         60 
MAARRSQRRR GRRGEPGTAL LVPLALGLGL ALACLGLLLA VVSLGSRASL SAQEPAQEEL 
        70         80         90        100        110        120 
VAEEDQDPSE LNPQTEESQD PAPFLNRLVR PRRSAPKGRK TRARRAIAAH YEVHPRPGQD 
       130        140        150        160        170        180 
GAQAGVDGTV SGWEEARINS SSPLRYNRQI GEFIVTRAGL YYLYCQVHFD EGKAVYLKLD 
       190        200        210        220        230        240 
LLVDGVLALR CLEEFSATAA SSLGPQLRLC QVSGLLALRP GSSLRIRTLP WAHLKAAPFL 
   
TYFGLFQVH



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...LFQVH 249 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)