O43521: Bcl-2-like protein 11

General Information

Protein names	- Bcl-2-like protein 11 - Bcl2-L-11 - Bcl2-interacting mediator of cell death
Gene names	BCL2L11
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O43521

4 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform BimL of Bcl-2-like protein 11 - Isoform BimS of Bcl-2-like protein 11 - Isoform Bim-alpha1 of Bcl-2-like protein 11 - Isoform Bim-alpha2 of Bcl-2-like protein 11 - Isoform Bim-alpha3 of Bcl-2-like protein 11 - Isoform Bim-alpha4 of Bcl-2-like protein 11 - Isoform Bim-alpha5 of Bcl-2-like protein 11 - Isoform Bim-alpha6 of Bcl-2-like protein 11 - Isoform Bim-beta1 of Bcl-2-like protein 11 - Isoform Bim-beta2 of Bcl-2-like protein 11 - Isoform Bim-beta3 of Bcl-2-like protein 11 - Isoform Bim-beta4 of Bcl-2-like protein 11 - Isoform Bim-beta5 of Bcl-2-like protein 11 - Isoform Bim-beta6 of Bcl-2-like protein 11 - Isoform Bim-beta7 of Bcl-2-like protein 11 - Isoform Bim-gamma of Bcl-2-like protein 11 - Isoform BimABC of Bcl-2-like protein 11 - Isoform BimAC of Bcl-2-like protein 11 - Isoform BimA of Bcl-2-like protein 11

Sequence View

        10         20         30         40         50         60
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP
        70         80         90        100        110        120
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP
       130        140        150        160        170        180
CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR
       190
MVILRLLRYI VRLVWRMH         10         20         30         40         50         60
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP
        70         80         90        100        110        120
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP
       130        140        150        160        170        180
CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR
       190
MVILRLLRYI VRLVWRMH         10         20         30         40         50         60
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP
        70         80         90        100        110        120
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP
       130        140        150        160        170        180
CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR
       190
MVILRLLRYI VRLVWRMH         10         20         30         40         50         60
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP
        70         80         90        100        110        120
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP
       130        140        150        160        170        180
CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR
       190
MVILRLLRYI VRLVWRMH         10         20         30         40         50         60
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP
        70         80         90        100        110        120
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP
       130        140        150        160        170        180
CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR
       190
MVILRLLRYI VRLVWRMH         10         20         30         40         50         60
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP
        70         80         90        100        110        120
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP
       130        140        150        160        170        180
CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR
       190
MVILRLLRYI VRLVWRMH         10         20         30         40         50         60
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP
        70         80         90        100        110        120
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP
       130        140        150        160        170        180
CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR
       190
MVILRLLRYI VRLVWRMH         10         20         30         40         50         60
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP
        70         80         90        100        110        120
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP
       130        140        150        160        170        180
CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR
       190
MVILRLLRYI VRLVWRMH         10         20         30         40         50         60
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP
        70         80         90        100        110        120
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP
       130        140        150        160        170        180
CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR
       190
MVILRLLRYI VRLVWRMH         10         20         30         40         50         60
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP
        70         80         90        100        110        120
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP
       130        140        150        160        170        180
CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR
       190
MVILRLLRYI VRLVWRMH         10         20         30         40         50         60
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP
        70         80         90        100        110        120
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP
       130        140        150        160        170        180
CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR
       190
MVILRLLRYI VRLVWRMH         10         20         30         40         50         60
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP
        70         80         90        100        110        120
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP
       130        140        150        160        170        180
CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR
       190
MVILRLLRYI VRLVWRMH         10         20         30         40         50         60
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP
        70         80         90        100        110        120
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP
       130        140        150        160        170        180
CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR
       190
MVILRLLRYI VRLVWRMH         10         20         30         40         50         60
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP
        70         80         90        100        110        120
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP
       130        140        150        160        170        180
CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR
       190
MVILRLLRYI VRLVWRMH         10         20         30         40         50         60
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP
        70         80         90        100        110        120
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP
       130        140        150        160        170        180
CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR
       190
MVILRLLRYI VRLVWRMH         10         20         30         40         50         60
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP
        70         80         90        100        110        120
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP
       130        140        150        160        170        180
CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR
       190
MVILRLLRYI VRLVWRMH         10         20         30         40         50         60
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP
        70         80         90        100        110        120
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP
       130        140        150        160        170        180
CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR
       190
MVILRLLRYI VRLVWRMH         10         20         30         40         50         60
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP
        70         80         90        100        110        120
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP
       130        140        150        160        170        180
CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR
       190
MVILRLLRYI VRLVWRMH         10         20         30         40         50         60
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP
        70         80         90        100        110        120
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP
       130        140        150        160        170        180
CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR
       190
MVILRLLRYI VRLVWRMH

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O43521-1-unknown	MAKQPS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O43521-1-unknown	MAKQPS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68062
O43521-1-unknown	MAKQPS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68063
O43521-1-unknown	MAKQPS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68064
O43521-1-unknown	MAKQPS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68065
O43521-1-unknown	MAKQPS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68066
O43521-1-unknown	MAKQPS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68067
O43521-1-unknown	MAKQPS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68068
O43521-1-unknown	MAKQPS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68069
O43521-1-unknown	MAKQPS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68080
O43521-2-acetylation	AKQPSD...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O43521-2-acetylation	AKQPSD...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178629
O43521-2-acetylation	AKQPSD...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178640
O43521-2-acetylation	AKQPSD...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178641
O43521-2-acetylation	AKQPSD...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178642
O43521-2-acetylation	AKQPSD...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178643
O43521-2-acetylation	AKQPSD...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178644
O43521-2-acetylation	AKQPSD...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178645
O43521-2-acetylation	AKQPSD...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178646
O43521-2-acetylation	AKQPSD...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178647
O43521-3-unknown	KQPSDV...	3		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000389225
O43521-3-unknown	KQPSDV...	3		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194573
O43521-3-unknown	KQPSDV...	3		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194574
O43521-3-unknown	KQPSDV...	3		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194575
O43521-3-unknown	KQPSDV...	3		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194576
O43521-3-unknown	KQPSDV...	3		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194577
O43521-3-unknown	KQPSDV...	3		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194578
O43521-3-unknown	KQPSDV...	3		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194579
O43521-3-unknown	KQPSDV...	3		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194580
O43521-3-unknown	KQPSDV...	3		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194581
O43521-14-unknown	REGRQL...	14		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1417
O43521-14-unknown	REGRQL...	14		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136482
O43521-14-unknown	REGRQL...	14		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136484
O43521-14-unknown	REGRQL...	14		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136485
O43521-14-unknown	REGRQL...	14		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136486
O43521-14-unknown	REGRQL...	14		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136487
O43521-14-unknown	REGRQL...	14		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136488
O43521-14-unknown	REGRQL...	14		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136490
O43521-14-unknown	REGRQL...	14		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136491
O43521-14-unknown	REGRQL...	14		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136493

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SSECDR	13	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1417
...PASPGP	71	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000376941
...PASPGP	71	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154061
...PASPGP	71	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154062
...SPPCQA	122	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000411870
...SPPCQA	122	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154626
...SPPCQA	122	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154628
...SPPCQA	122	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154625
...SPPCQA	122	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154627
...VWRMH	198	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VWRMH	198	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63698
...VWRMH	198	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63681
...VWRMH	198	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63680

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	13	ECDR.\|.REGR	inferred from experiment	unknown	MEROPS	Zhou Q	Chen D et al.:Caspase cleavage of BimEL trigg... (C14.003)	14732682,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)