TopFIND 4.0

O43541: Mothers against decapentaplegic homolog 6

General Information

Protein names
- Mothers against decapentaplegic homolog 6
- MAD homolog 6
- Mothers against DPP homolog 6
- SMAD family member 6
- SMAD 6
- Smad6
- hSMAD6
Gene names SMAD6
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID O43541

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MFRSKRSGLV RRLWRSRVVP DREEGGSGGG GGGDEDGSLG SRAEPAPRAR EGGGCGRSEV 
        70         80         90        100        110        120 
RPVAPRRPRD AVGQRGAQGA GRRRRAGGPP RPMSEPGAGA GSSLLDVAEP GGPGWLPESD 
       130        140        150        160        170        180 
CETVTCCLFS ERDAAGAPRD ASDPLAGAAL EPAGGGRSRE ARSRLLLLEQ ELKTVTYSLL 
       190        200        210        220        230        240 
KRLKERSLDT LLEAVESRGG VPGGCVLVPR ADLRLGGQPA PPQLLLGRLF RWPDLQHAVE 
       250        260        270        280        290        300 
LKPLCGCHSF AAAADGPTVC CNPYHFSRLC GPESPPPPYS RLSPRDEYKP LDLSDSTLSY 
       310        320        330        340        350        360 
TETEATNSLI TAPGEFSDAS MSPDATKPSH WCSVAYWEHR TRVGRLYAVY DQAVSIFYDL 
       370        380        390        400        410        420 
PQGSGFCLGQ LNLEQRSESV RRTRSKIGFG ILLSKEPDGV WAYNRGEHPI FVNSPTLDAP 
       430        440        450        460        470        480 
GGRALVVRKV PPGYSIKVFD FERSGLQHAP EPDAADGPYD PNSVRISFAK GWGPCYSRQF 
       490    
ITSCPCWLEI LLNNPR

Isoforms

- Isoform B of Mothers against decapentaplegic homolog 6 - Isoform D of Mothers against decapentaplegic homolog 6

Sequence View

        10         20         30         40         50         60 
MFRSKRSGLV RRLWRSRVVP DREEGGSGGG GGGDEDGSLG SRAEPAPRAR EGGGCGRSEV 
        70         80         90        100        110        120 
RPVAPRRPRD AVGQRGAQGA GRRRRAGGPP RPMSEPGAGA GSSLLDVAEP GGPGWLPESD 
       130        140        150        160        170        180 
CETVTCCLFS ERDAAGAPRD ASDPLAGAAL EPAGGGRSRE ARSRLLLLEQ ELKTVTYSLL 
       190        200        210        220        230        240 
KRLKERSLDT LLEAVESRGG VPGGCVLVPR ADLRLGGQPA PPQLLLGRLF RWPDLQHAVE 
       250        260        270        280        290        300 
LKPLCGCHSF AAAADGPTVC CNPYHFSRLC GPESPPPPYS RLSPRDEYKP LDLSDSTLSY 
       310        320        330        340        350        360 
TETEATNSLI TAPGEFSDAS MSPDATKPSH WCSVAYWEHR TRVGRLYAVY DQAVSIFYDL 
       370        380        390        400        410        420 
PQGSGFCLGQ LNLEQRSESV RRTRSKIGFG ILLSKEPDGV WAYNRGEHPI FVNSPTLDAP 
       430        440        450        460        470        480 
GGRALVVRKV PPGYSIKVFD FERSGLQHAP EPDAADGPYD PNSVRISFAK GWGPCYSRQF 
       490    
ITSCPCWLEI LLNNPR         10         20         30         40         50         60 
MFRSKRSGLV RRLWRSRVVP DREEGGSGGG GGGDEDGSLG SRAEPAPRAR EGGGCGRSEV 
        70         80         90        100        110        120 
RPVAPRRPRD AVGQRGAQGA GRRRRAGGPP RPMSEPGAGA GSSLLDVAEP GGPGWLPESD 
       130        140        150        160        170        180 
CETVTCCLFS ERDAAGAPRD ASDPLAGAAL EPAGGGRSRE ARSRLLLLEQ ELKTVTYSLL 
       190        200        210        220        230        240 
KRLKERSLDT LLEAVESRGG VPGGCVLVPR ADLRLGGQPA PPQLLLGRLF RWPDLQHAVE 
       250        260        270        280        290        300 
LKPLCGCHSF AAAADGPTVC CNPYHFSRLC GPESPPPPYS RLSPRDEYKP LDLSDSTLSY 
       310        320        330        340        350        360 
TETEATNSLI TAPGEFSDAS MSPDATKPSH WCSVAYWEHR TRVGRLYAVY DQAVSIFYDL 
       370        380        390        400        410        420 
PQGSGFCLGQ LNLEQRSESV RRTRSKIGFG ILLSKEPDGV WAYNRGEHPI FVNSPTLDAP 
       430        440        450        460        470        480 
GGRALVVRKV PPGYSIKVFD FERSGLQHAP EPDAADGPYD PNSVRISFAK GWGPCYSRQF 
       490    
ITSCPCWLEI LLNNPR



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    O43541-1-unknown MFRSKR... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    O43541-1-unknown MFRSKR... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt89982

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...LNNPR 496 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...LNNPR 496 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt85599

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)