TopFIND 4.0

O43781: Dual specificity tyrosine-phosphorylation-regulated kinase 3

General Information

Protein names
- Dual specificity tyrosine-phosphorylation-regulated kinase 3
- 2.7.12.1 {ECO:0000269|PubMed:23415227, ECO:0000269|PubMed:29634919, ECO:0000269|PubMed:29973724, ECO:0000269|PubMed:9748265}
- Regulatory erythroid kinase {ECO:0000303|PubMed:10779429}
- REDK {ECO:0000303|PubMed:10779429}
Gene names DYRK3
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID O43781

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MGGTARGPGR KDAGPPGAGL PPQQRRLGDG VYDTFMMIDE TKCPPCSNVL CNPSEPPPPR 
        70         80         90        100        110        120 
RLNMTTEQFT GDHTQHFLDG GEMKVEQLFQ EFGNRKSNTI QSDGISDSEK CSPTVSQGKS 
       130        140        150        160        170        180 
SDCLNTVKSN SSSKAPKVVP LTPEQALKQY KHHLTAYEKL EIINYPEIYF VGPNAKKRHG 
       190        200        210        220        230        240 
VIGGPNNGGY DDADGAYIHV PRDHLAYRYE VLKIIGKGSF GQVARVYDHK LRQYVALKMV 
       250        260        270        280        290        300 
RNEKRFHRQA AEEIRILEHL KKQDKTGSMN VIHMLESFTF RNHVCMAFEL LSIDLYELIK 
       310        320        330        340        350        360 
KNKFQGFSVQ LVRKFAQSIL QSLDALHKNK IIHCDLKPEN ILLKHHGRSS TKVIDFGSSC 
       370        380        390        400        410        420 
FEYQKLYTYI QSRFYRAPEI ILGSRYSTPI DIWSFGCILA ELLTGQPLFP GEDEGDQLAC 
       430        440        450        460        470        480 
MMELLGMPPP KLLEQSKRAK YFINSKGIPR YCSVTTQADG RVVLVGGRSR RGKKRGPPGS 
       490        500        510        520        530        540 
KDWGTALKGC DDYLFIEFLK RCLHWDPSAR LTPAQALRHP WISKSVPRPL TTIDKVSGKR 
       550        560        570        580    
VVNPASAFQG LGSKLPPVVG IANKLKANLM SETNGSIPLC SVLPKLIS

Isoforms

- Isoform 2 of Dual specificity tyrosine-phosphorylation-regulated kinase 3

Sequence View

        10         20         30         40         50         60 
MGGTARGPGR KDAGPPGAGL PPQQRRLGDG VYDTFMMIDE TKCPPCSNVL CNPSEPPPPR 
        70         80         90        100        110        120 
RLNMTTEQFT GDHTQHFLDG GEMKVEQLFQ EFGNRKSNTI QSDGISDSEK CSPTVSQGKS 
       130        140        150        160        170        180 
SDCLNTVKSN SSSKAPKVVP LTPEQALKQY KHHLTAYEKL EIINYPEIYF VGPNAKKRHG 
       190        200        210        220        230        240 
VIGGPNNGGY DDADGAYIHV PRDHLAYRYE VLKIIGKGSF GQVARVYDHK LRQYVALKMV 
       250        260        270        280        290        300 
RNEKRFHRQA AEEIRILEHL KKQDKTGSMN VIHMLESFTF RNHVCMAFEL LSIDLYELIK 
       310        320        330        340        350        360 
KNKFQGFSVQ LVRKFAQSIL QSLDALHKNK IIHCDLKPEN ILLKHHGRSS TKVIDFGSSC 
       370        380        390        400        410        420 
FEYQKLYTYI QSRFYRAPEI ILGSRYSTPI DIWSFGCILA ELLTGQPLFP GEDEGDQLAC 
       430        440        450        460        470        480 
MMELLGMPPP KLLEQSKRAK YFINSKGIPR YCSVTTQADG RVVLVGGRSR RGKKRGPPGS 
       490        500        510        520        530        540 
KDWGTALKGC DDYLFIEFLK RCLHWDPSAR LTPAQALRHP WISKSVPRPL TTIDKVSGKR 
       550        560        570        580    
VVNPASAFQG LGSKLPPVVG IANKLKANLM SETNGSIPLC SVLPKLIS



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(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    O43781-1-unknown MGGTAR... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...PKLIS 588 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...PKLIS 588 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt69066

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)