TopFIND 4.0

O54785: LIM domain kinase 2

General Information

Protein names
- LIM domain kinase 2
- LIMK-2
- 2.7.11.1
Gene names Limk2
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID O54785

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAALAGDEAW RCRGCGTYVP LSQRLYRTAN EAWHGSCFRC SECQESLTNW YYEKDGKLYC 
        70         80         90        100        110        120 
HKDYWAKFGE FCHGCSLLMT GPAMVAGEFK YHPECFACMS CKVIIEDGDA YALVQHATLY 
       130        140        150        160        170        180 
CGKCHNEVVL APMFERLSTE SVQDQLPYSV TLISMPATTE CRRGFSVTVE SASSNYATTV 
       190        200        210        220        230        240 
QVKEVNRMHI SPNNRNAIHP GDRILEINGT PVRTLRVEEV EDAIKQTSQT LQLLIEHDPV 
       250        260        270        280        290        300 
PQRLDQLRLD ARLPPHMQST GHTLMLSTLD TKENQEGTLR RRSLRRSNSI SKSPGPSSPK 
       310        320        330        340        350        360 
EPLLLSRDIS RSESLRCSSS YSQQIFRPCD LIHGEVLGKG FFGQAIKVTH KATGKVMVMK 
       370        380        390        400        410        420 
ELIRCDEETQ KTFLTEVKVM RSLDHPNVLK FIGVLYKDKK LNLLTEYIEG GTLKDFLRSV 
       430        440        450        460        470        480 
DPFPWQQKVR FAKGISSGMA YLHSMCIIHR DLNSHNCLIK LDKTVVVADF GLSRLIVEER 
       490        500        510        520        530        540 
KRPPVEKATT KKRTLRKSDR KKRYTVVGNP YWMAPEMLNG KSYDETVDVF SFGIVLCEII 
       550        560        570        580        590        600 
GQVYADPDCL PRTLDFGLNV KLFWEKFVPT DCPPAFFPLA AICCKLEPES RPAFSKLEDS 
       610        620        630    
FEALSLFLGE LAIPLPAELE DLDHTVSMEY GLTRDSPP

Isoforms

- Isoform 2 of LIM domain kinase 2 - Isoform 3 of LIM domain kinase 2

Sequence View

        10         20         30         40         50         60 
MAALAGDEAW RCRGCGTYVP LSQRLYRTAN EAWHGSCFRC SECQESLTNW YYEKDGKLYC 
        70         80         90        100        110        120 
HKDYWAKFGE FCHGCSLLMT GPAMVAGEFK YHPECFACMS CKVIIEDGDA YALVQHATLY 
       130        140        150        160        170        180 
CGKCHNEVVL APMFERLSTE SVQDQLPYSV TLISMPATTE CRRGFSVTVE SASSNYATTV 
       190        200        210        220        230        240 
QVKEVNRMHI SPNNRNAIHP GDRILEINGT PVRTLRVEEV EDAIKQTSQT LQLLIEHDPV 
       250        260        270        280        290        300 
PQRLDQLRLD ARLPPHMQST GHTLMLSTLD TKENQEGTLR RRSLRRSNSI SKSPGPSSPK 
       310        320        330        340        350        360 
EPLLLSRDIS RSESLRCSSS YSQQIFRPCD LIHGEVLGKG FFGQAIKVTH KATGKVMVMK 
       370        380        390        400        410        420 
ELIRCDEETQ KTFLTEVKVM RSLDHPNVLK FIGVLYKDKK LNLLTEYIEG GTLKDFLRSV 
       430        440        450        460        470        480 
DPFPWQQKVR FAKGISSGMA YLHSMCIIHR DLNSHNCLIK LDKTVVVADF GLSRLIVEER 
       490        500        510        520        530        540 
KRPPVEKATT KKRTLRKSDR KKRYTVVGNP YWMAPEMLNG KSYDETVDVF SFGIVLCEII 
       550        560        570        580        590        600 
GQVYADPDCL PRTLDFGLNV KLFWEKFVPT DCPPAFFPLA AICCKLEPES RPAFSKLEDS 
       610        620        630    
FEALSLFLGE LAIPLPAELE DLDHTVSMEY GLTRDSPP         10         20         30         40         50         60 
MAALAGDEAW RCRGCGTYVP LSQRLYRTAN EAWHGSCFRC SECQESLTNW YYEKDGKLYC 
        70         80         90        100        110        120 
HKDYWAKFGE FCHGCSLLMT GPAMVAGEFK YHPECFACMS CKVIIEDGDA YALVQHATLY 
       130        140        150        160        170        180 
CGKCHNEVVL APMFERLSTE SVQDQLPYSV TLISMPATTE CRRGFSVTVE SASSNYATTV 
       190        200        210        220        230        240 
QVKEVNRMHI SPNNRNAIHP GDRILEINGT PVRTLRVEEV EDAIKQTSQT LQLLIEHDPV 
       250        260        270        280        290        300 
PQRLDQLRLD ARLPPHMQST GHTLMLSTLD TKENQEGTLR RRSLRRSNSI SKSPGPSSPK 
       310        320        330        340        350        360 
EPLLLSRDIS RSESLRCSSS YSQQIFRPCD LIHGEVLGKG FFGQAIKVTH KATGKVMVMK 
       370        380        390        400        410        420 
ELIRCDEETQ KTFLTEVKVM RSLDHPNVLK FIGVLYKDKK LNLLTEYIEG GTLKDFLRSV 
       430        440        450        460        470        480 
DPFPWQQKVR FAKGISSGMA YLHSMCIIHR DLNSHNCLIK LDKTVVVADF GLSRLIVEER 
       490        500        510        520        530        540 
KRPPVEKATT KKRTLRKSDR KKRYTVVGNP YWMAPEMLNG KSYDETVDVF SFGIVLCEII 
       550        560        570        580        590        600 
GQVYADPDCL PRTLDFGLNV KLFWEKFVPT DCPPAFFPLA AICCKLEPES RPAFSKLEDS 
       610        620        630    
FEALSLFLGE LAIPLPAELE DLDHTVSMEY GLTRDSPP



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    O54785-1-unknown MAALAG... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    O54785-188-unknown MHISPN... 188 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt79602
    O54785-188-unknown MHISPN... 188 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt109306

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)