O54967: Activated CDC42 kinase 1

General Information

Protein names	- Activated CDC42 kinase 1 - ACK-1 - 2.7.10.2 - 2.7.11.1 - Non-receptor protein tyrosine kinase Ack - Tyrosine kinase non-receptor protein 2
Gene names	Tnk2
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	O54967

2 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Activated CDC42 kinase 1 - Isoform 3 of Activated CDC42 kinase 1

Sequence View

        10         20         30         40         50         60
MQPEEGTGWL LELLSEVQLQ QYFLRLRDDL NITRLSHFEY VKNEDLEKIG MGRPGQRRLW
        70         80         90        100        110        120
EAVKRRKAMC KRKSWMSKVF SGKRLEAEFP SQHSQSTFRK PSPTPGSLPG EGTLQSLTCL
       130        140        150        160        170        180
IGEKDLRLLE KLGDGSFGVV RRGEWDAPAG KTVSVAVKCL KPDVLSQPEA MDDFIREVNA
       190        200        210        220        230        240
MHSLDHRNLI RLYGVVLTLP MKMVTELAPL GSLLDRLRKH QGHFLLGTLS RYAVQVAEGM
       250        260        270        280        290        300
AYLESKRFIH RDLAARNLLL ATRDLVKIGD FGLMRALPQN DDHYVMQEHR KVPFAWCAPE
       310        320        330        340        350        360
SLKTRTFSHA SDTWMFGVTL WEMFTYGQEP WIGLNGSQIL HKIDKEGERL PRPEDCPQDI
       370        380        390        400        410        420
YNVMVQCWAH KPEDRPTFVA LRDFLLEAQP TDMRALQDFE EPDKLHIQMN DVITVIEGRA
       430        440        450        460        470        480
ENYWWRGQNT RTLCVGPFPR NVVTSVAGLS AQDISQPLQN SFIHTGHGDS DPRHCWGFPD
       490        500        510        520        530        540
RIDELYLGNP MDPPDLLSVE LSTSRPTQHL GRVKREPPPR PPQPAIFTQK TTYDPVSEDP
       550        560        570        580        590        600
DPLSSDFKRL GLRKPALPRG LWLAKPSARV PGTKADRSSG GEVTLIDFGE EPVVPTPRPC
       610        620        630        640        650        660
APSLAQLAMD ACSLLDKTPP QSPTRALPRP LHPTPVVDWD ARPLPPPPAY DDVAQDEDDF
       670        680        690        700        710        720
EVCSINSTLV GAGLPAGPSQ GETNYAFVPE QAQMPPALED NLFLPPQGGG KPPSSVQTAE
       730        740        750        760        770        780
IFQALQQECM RQLQVPTGQL TPSPTPGGDD KPQVPPRVPI PPRPTRPRVE LSPAPSGEEE
       790        800        810        820        830        840
TSRWPGPASP PRVPPREPLS PQGSRTPSPL VPPGSSPLPH RLSSSPGKTM PTTQSFASDP
       850        860        870        880        890        900
KYATPQVIQA PGPRAGPCIL PIVRDGRKVS STHYYLLPER PPYLERYQRF LREAQSPEEP
       910        920        930        940        950        960
AALPVPPLLP PPSTPAPAAP TATVRPMPQA APDPKANFST NNSNPGARPP SLRAAARLPQ
       970        980        990       1000       1010       1020
RGCPGDGQEA ARPADKVQML QAMVHGVTTE ECQAALQSHS WSVQRAAQYL KVEQLFGLGL
      1030       1040       1050
RPRVECHKVL EMFDWNLEQA GCHLLGSCGP AHHKR         10         20         30         40         50         60
MQPEEGTGWL LELLSEVQLQ QYFLRLRDDL NITRLSHFEY VKNEDLEKIG MGRPGQRRLW
        70         80         90        100        110        120
EAVKRRKAMC KRKSWMSKVF SGKRLEAEFP SQHSQSTFRK PSPTPGSLPG EGTLQSLTCL
       130        140        150        160        170        180
IGEKDLRLLE KLGDGSFGVV RRGEWDAPAG KTVSVAVKCL KPDVLSQPEA MDDFIREVNA
       190        200        210        220        230        240
MHSLDHRNLI RLYGVVLTLP MKMVTELAPL GSLLDRLRKH QGHFLLGTLS RYAVQVAEGM
       250        260        270        280        290        300
AYLESKRFIH RDLAARNLLL ATRDLVKIGD FGLMRALPQN DDHYVMQEHR KVPFAWCAPE
       310        320        330        340        350        360
SLKTRTFSHA SDTWMFGVTL WEMFTYGQEP WIGLNGSQIL HKIDKEGERL PRPEDCPQDI
       370        380        390        400        410        420
YNVMVQCWAH KPEDRPTFVA LRDFLLEAQP TDMRALQDFE EPDKLHIQMN DVITVIEGRA
       430        440        450        460        470        480
ENYWWRGQNT RTLCVGPFPR NVVTSVAGLS AQDISQPLQN SFIHTGHGDS DPRHCWGFPD
       490        500        510        520        530        540
RIDELYLGNP MDPPDLLSVE LSTSRPTQHL GRVKREPPPR PPQPAIFTQK TTYDPVSEDP
       550        560        570        580        590        600
DPLSSDFKRL GLRKPALPRG LWLAKPSARV PGTKADRSSG GEVTLIDFGE EPVVPTPRPC
       610        620        630        640        650        660
APSLAQLAMD ACSLLDKTPP QSPTRALPRP LHPTPVVDWD ARPLPPPPAY DDVAQDEDDF
       670        680        690        700        710        720
EVCSINSTLV GAGLPAGPSQ GETNYAFVPE QAQMPPALED NLFLPPQGGG KPPSSVQTAE
       730        740        750        760        770        780
IFQALQQECM RQLQVPTGQL TPSPTPGGDD KPQVPPRVPI PPRPTRPRVE LSPAPSGEEE
       790        800        810        820        830        840
TSRWPGPASP PRVPPREPLS PQGSRTPSPL VPPGSSPLPH RLSSSPGKTM PTTQSFASDP
       850        860        870        880        890        900
KYATPQVIQA PGPRAGPCIL PIVRDGRKVS STHYYLLPER PPYLERYQRF LREAQSPEEP
       910        920        930        940        950        960
AALPVPPLLP PPSTPAPAAP TATVRPMPQA APDPKANFST NNSNPGARPP SLRAAARLPQ
       970        980        990       1000       1010       1020
RGCPGDGQEA ARPADKVQML QAMVHGVTTE ECQAALQSHS WSVQRAAQYL KVEQLFGLGL
      1030       1040       1050
RPRVECHKVL EMFDWNLEQA GCHLLGSCGP AHHKR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O54967-1-unknown	MQPEEG...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O54967-1-unknown	MQPEEG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66165
O54967-1-unknown	MQPEEG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66166
O54967-491-unknown	MDPPDL...	491	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000110775
O54967-491-unknown	MDPPDL...	491	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000110773
O54967-491-unknown	MDPPDL...	491	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000129382
O54967-491-unknown	MDPPDL...	491	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000110774
O54967-491-unknown	MDPPDL...	491	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt132984
O54967-491-unknown	MDPPDL...	491	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt132985

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PCAPSL	603	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000129382
...PCAPSL	603	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt115350
...PCAPSL	603	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt115351
...NSTLVG	670	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000125905
...NSTLVG	670	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt115356
...NSTLVG	670	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt115357
...DKPQVP	754	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000110774
...DKPQVP	754	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt115353
...DKPQVP	754	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt115354
...AHHKR	1055	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...AHHKR	1055	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61783
...AHHKR	1055	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61784

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)