O54992: MAP kinase-activated protein kinase 5

General Information

Protein names	- MAP kinase-activated protein kinase 5 - MAPK-activated protein kinase 5 - MAPKAP kinase 5 - MAPKAPK-5 - 2.7.11.1
Gene names	Mapkapk5
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	O54992

2 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of MAP kinase-activated protein kinase 5 - Isoform 3 of MAP kinase-activated protein kinase 5 - Isoform 4 of MAP kinase-activated protein kinase 5 - Isoform 5 of MAP kinase-activated protein kinase 5

Sequence View

        10         20         30         40         50         60
MSEDSDMEKA IKETSILEEY SINWTQKLGA GISGPVRVCV KKSTQERFAL KILLDRPKAR
        70         80         90        100        110        120
NEVRLHMMCA THPNIVQIIE VFANSVQFPH ESSPRARLLI VMEMMEGGEL FHRISQHRHF
       130        140        150        160        170        180
TEKQASQVTK QIALALQHCH LLNIAHRDLK PENLLFKDNS LDAPVKLCDF GFAKVDQGDL
       190        200        210        220        230        240
MTPQFTPYYV APQVLEAQRR HQKEKSGIIP TSPTPYTYNK SCDLWSLGVI IYVMLCGYPP
       250        260        270        280        290        300
FYSKHHSRTI PKDMRKKIMT GSFEFPEEEW SQISEMAKDV VRKLLKVKPE ERLTIEGVLD
       310        320        330        340        350        360
HPWLNSTEAL DNVLPSAQLM MDKAVVAGIQ QAHAEQLANM RIQDLKVSLK PLHSVNNPIL
       370        380        390        400        410        420
RKRKLLGTKP KDGIYIHDHE NGTEDSNVAL EKLRDVIAQC ILPQAGKGEN EDEKLNEVMQ
       430        440        450        460        470
EAWKYNRECK LLRDALQSFS WNGRGFTDKV DRLKLAEVVK QVIEEQTLPH EPQ         10         20         30         40         50         60
MSEDSDMEKA IKETSILEEY SINWTQKLGA GISGPVRVCV KKSTQERFAL KILLDRPKAR
        70         80         90        100        110        120
NEVRLHMMCA THPNIVQIIE VFANSVQFPH ESSPRARLLI VMEMMEGGEL FHRISQHRHF
       130        140        150        160        170        180
TEKQASQVTK QIALALQHCH LLNIAHRDLK PENLLFKDNS LDAPVKLCDF GFAKVDQGDL
       190        200        210        220        230        240
MTPQFTPYYV APQVLEAQRR HQKEKSGIIP TSPTPYTYNK SCDLWSLGVI IYVMLCGYPP
       250        260        270        280        290        300
FYSKHHSRTI PKDMRKKIMT GSFEFPEEEW SQISEMAKDV VRKLLKVKPE ERLTIEGVLD
       310        320        330        340        350        360
HPWLNSTEAL DNVLPSAQLM MDKAVVAGIQ QAHAEQLANM RIQDLKVSLK PLHSVNNPIL
       370        380        390        400        410        420
RKRKLLGTKP KDGIYIHDHE NGTEDSNVAL EKLRDVIAQC ILPQAGKGEN EDEKLNEVMQ
       430        440        450        460        470
EAWKYNRECK LLRDALQSFS WNGRGFTDKV DRLKLAEVVK QVIEEQTLPH EPQ         10         20         30         40         50         60
MSEDSDMEKA IKETSILEEY SINWTQKLGA GISGPVRVCV KKSTQERFAL KILLDRPKAR
        70         80         90        100        110        120
NEVRLHMMCA THPNIVQIIE VFANSVQFPH ESSPRARLLI VMEMMEGGEL FHRISQHRHF
       130        140        150        160        170        180
TEKQASQVTK QIALALQHCH LLNIAHRDLK PENLLFKDNS LDAPVKLCDF GFAKVDQGDL
       190        200        210        220        230        240
MTPQFTPYYV APQVLEAQRR HQKEKSGIIP TSPTPYTYNK SCDLWSLGVI IYVMLCGYPP
       250        260        270        280        290        300
FYSKHHSRTI PKDMRKKIMT GSFEFPEEEW SQISEMAKDV VRKLLKVKPE ERLTIEGVLD
       310        320        330        340        350        360
HPWLNSTEAL DNVLPSAQLM MDKAVVAGIQ QAHAEQLANM RIQDLKVSLK PLHSVNNPIL
       370        380        390        400        410        420
RKRKLLGTKP KDGIYIHDHE NGTEDSNVAL EKLRDVIAQC ILPQAGKGEN EDEKLNEVMQ
       430        440        450        460        470
EAWKYNRECK LLRDALQSFS WNGRGFTDKV DRLKLAEVVK QVIEEQTLPH EPQ         10         20         30         40         50         60
MSEDSDMEKA IKETSILEEY SINWTQKLGA GISGPVRVCV KKSTQERFAL KILLDRPKAR
        70         80         90        100        110        120
NEVRLHMMCA THPNIVQIIE VFANSVQFPH ESSPRARLLI VMEMMEGGEL FHRISQHRHF
       130        140        150        160        170        180
TEKQASQVTK QIALALQHCH LLNIAHRDLK PENLLFKDNS LDAPVKLCDF GFAKVDQGDL
       190        200        210        220        230        240
MTPQFTPYYV APQVLEAQRR HQKEKSGIIP TSPTPYTYNK SCDLWSLGVI IYVMLCGYPP
       250        260        270        280        290        300
FYSKHHSRTI PKDMRKKIMT GSFEFPEEEW SQISEMAKDV VRKLLKVKPE ERLTIEGVLD
       310        320        330        340        350        360
HPWLNSTEAL DNVLPSAQLM MDKAVVAGIQ QAHAEQLANM RIQDLKVSLK PLHSVNNPIL
       370        380        390        400        410        420
RKRKLLGTKP KDGIYIHDHE NGTEDSNVAL EKLRDVIAQC ILPQAGKGEN EDEKLNEVMQ
       430        440        450        460        470
EAWKYNRECK LLRDALQSFS WNGRGFTDKV DRLKLAEVVK QVIEEQTLPH EPQ

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O54992-1-unknown	MSEDSD...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O54992-1-unknown	MSEDSD...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80388
O54992-1-unknown	MSEDSD...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80391
O54992-102-unknown	MEMMEG...	102	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000107411
O54992-102-unknown	MEMMEG...	102	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196990
O54992-102-unknown	MEMMEG...	102	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196991

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PHEPQ	473	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PHEPQ	473	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76008
...PHEPQ	473	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76007
...PHEPQ	473	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76006
...PHEPQ	473	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76009

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)