TopFIND 4.0

O55187: E3 SUMO-protein ligase CBX4

General Information

Protein names
- E3 SUMO-protein ligase CBX4
- 2.3.2.-
- Chromobox protein homolog 4
- E3 SUMO-protein transferase CBX4 {ECO:0000305}
- Polycomb 2 homolog
- Pc2
- mPc2
Gene names Cbx4
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID O55187

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MELPAVGEHV FAVESIEKKR IRKGRVEYLV KWRGWSPKYN TWEPEENILD PRLLIAFQNR 
        70         80         90        100        110        120 
ERQEQLMGYR KRGPKPKPLV VQVPTFARRS NVLTGLQDSS ADNRAKLELG TQGKGQGHQY 
       130        140        150        160        170        180 
ELNSKKHHQY QPHSKERSGK PPPPGKSGKY YYQLNSKKHH PYQPDPKMYD LQYQGGHKEA 
       190        200        210        220        230        240 
PSPTCPDLGT KSHPPDKWAH GAAAKGYLGA VKPLGGGAGA PGKGSEKGPP NGMTPAPKEA 
       250        260        270        280        290        300 
VTGNGIGGKM KIVKNKNKNG RIVIVMSKYM ENGMQAVKIK SGEAAEGEAR SPSHKKRAAE 
       310        320        330        340        350        360 
ERHPQGDRTF KKAAGASEEK KAEVPCKRRE EEALVSGDAQ PQDLGSRKLS PTKEAFGEQP 
       370        380        390        400        410        420 
LQLTTKPDLL AWDPARSSHP PAHHHHHHHH HHHHHTVGLN LSHARKRCLS ETHGEREPCK 
       430        440        450        460        470        480 
KRLTARSIST PTCLGGSPVS EHPANVSPTA ASLPQPEVIL LDSDLDEPID LRCVKMRSDA 
       490        500        510        520        530        540 
GEPPSTLQVK PEAPAVAAVV APAPASEKPP AEAQEEPVEP LSEFKPFFGN IIITDVTANC 
       550    
LTVTFKEYVT V

Isoforms

- Isoform 2 of E3 SUMO-protein ligase CBX4

Sequence View

        10         20         30         40         50         60 
MELPAVGEHV FAVESIEKKR IRKGRVEYLV KWRGWSPKYN TWEPEENILD PRLLIAFQNR 
        70         80         90        100        110        120 
ERQEQLMGYR KRGPKPKPLV VQVPTFARRS NVLTGLQDSS ADNRAKLELG TQGKGQGHQY 
       130        140        150        160        170        180 
ELNSKKHHQY QPHSKERSGK PPPPGKSGKY YYQLNSKKHH PYQPDPKMYD LQYQGGHKEA 
       190        200        210        220        230        240 
PSPTCPDLGT KSHPPDKWAH GAAAKGYLGA VKPLGGGAGA PGKGSEKGPP NGMTPAPKEA 
       250        260        270        280        290        300 
VTGNGIGGKM KIVKNKNKNG RIVIVMSKYM ENGMQAVKIK SGEAAEGEAR SPSHKKRAAE 
       310        320        330        340        350        360 
ERHPQGDRTF KKAAGASEEK KAEVPCKRRE EEALVSGDAQ PQDLGSRKLS PTKEAFGEQP 
       370        380        390        400        410        420 
LQLTTKPDLL AWDPARSSHP PAHHHHHHHH HHHHHTVGLN LSHARKRCLS ETHGEREPCK 
       430        440        450        460        470        480 
KRLTARSIST PTCLGGSPVS EHPANVSPTA ASLPQPEVIL LDSDLDEPID LRCVKMRSDA 
       490        500        510        520        530        540 
GEPPSTLQVK PEAPAVAAVV APAPASEKPP AEAQEEPVEP LSEFKPFFGN IIITDVTANC 
       550    
LTVTFKEYVT V



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    O55187-1-unknown MELPAV... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    O55187-67-unknown MGYRKR... 67 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt69488

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...EYVTV 551 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...EYVTV 551 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt65106

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)