O60244: Mediator of RNA polymerase II transcription subunit 14

General Information

Protein names	- Mediator of RNA polymerase II transcription subunit 14 - Activator-recruited cofactor 150 kDa component - ARC150 - Cofactor required for Sp1 transcriptional activation subunit 2 - CRSP complex subunit 2 - Mediator complex subunit 14 - RGR1 homolog - hRGR1 - Thyroid hormone receptor-associated protein complex 170 kDa component - Trap170 - Transcriptional coactivator CRSP150 - Vitamin D3 receptor-interacting protein complex 150 kDa component - DRIP150
Gene names	MED14
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O60244

4 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAPVQLENHQ LVPPGGGGGG SGGPPSAPAP PPPGAAVAAA AAAAASPGYR LSTLIEFLLH
        70         80         90        100        110        120
RAYSELMVLT DLLPRKSDVE RKIEIVQFAS RTRQLFVRLL ALVKWANNAG KVEKCAMISS
       130        140        150        160        170        180
FLDQQAILFV DTADRLASLA RDALVHARLP SFAIPYAIDV LTTGSYPRLP TCIRDKIIPP
       190        200        210        220        230        240
DPITKIEKQA TLHQLNQILR HRLVTTDLPP QLANLTVANG RVKFRVEGEF EATLTVMGDD
       250        260        270        280        290        300
PDVPWRLLKL EILVEDKETG DGRALVHSMQ ISFIHQLVQS RLFADEKPLQ DMYNCLHSFC
       310        320        330        340        350        360
LSLQLEVLHS QTLMLIRERW GDLVQVERYH AGKCLSLSVW NQQVLGRKTG TASVHKVTIK
       370        380        390        400        410        420
IDENDVSKPL QIFHDPPLPA SDSKLVERAM KIDHLSIEKL LIDSVHARAH QKLQELKAIL
       430        440        450        460        470        480
RGFNANENSS IETALPALVV PILEPCGNSE CLHIFVDLHS GMFQLMLYGL DQATLDDMEK
       490        500        510        520        530        540
SVNDDMKRII PWIQQLKFWL GQQRCKQSIK HLPTISSETL QLSNYSTHPI GNLSKNKLFI
       550        560        570        580        590        600
KLTRLPQYYI VVEMLEVPNK PTQLSYKYYF MSVNAADRED SPAMALLLQQ FKENIQDLVF
       610        620        630        640        650        660
RTKTGKQTRT NAKRKLSDDP CPVESKKTKR AGEMCAFNKV LAHFVAMCDT NMPFVGLRLE
       670        680        690        700        710        720
LSNLEIPHQG VQVEGDGFSH AIRLLKIPPC KGITEETQKA LDRSLLDCTF RLQGRNNRTW
       730        740        750        760        770        780
VAELVFANCP LNGTSTREQG PSRHVYLTYE NLLSEPVGGR KVVEMFLNDW NSIARLYECV
       790        800        810        820        830        840
LEFARSLPDI PAHLNIFSEV RVYNYRKLIL CYGTTKGSSI SIQWNSIHQK FHISLGTVGP
       850        860        870        880        890        900
NSGCSNCHNT ILHQLQEMFN KTPNVVQLLQ VLFDTQAPLN AINKLPTVPM LGLTQRTNTA
       910        920        930        940        950        960
YQCFSILPQS STHIRLAFRN MYCIDIYCRS RGVVAIRDGA YSLFDNSKLV EGFYPAPGLK
       970        980        990       1000       1010       1020
TFLNMFVDSN QDARRRSVNE DDNPPSPIGG DMMDSLISQL QPPPQQQPFP KQPGTSGAYP
      1030       1040       1050       1060       1070       1080
LTSPPTSYHS TVNQSPSMMH TQSPGNLHAA SSPSGALRAP SPASFVPTPP PSSHGISIGP
      1090       1100       1110       1120       1130       1140
GASFASPHGT LDPSSPYTMV SPSGRAGNWP GSPQVSGPSP AARMPGMSPA NPSLHSPVPD
      1150       1160       1170       1180       1190       1200
ASHSPRAGTS SQTMPTNMPP PRKLPQRSWA ASIPTILTHS ALNILLLPSP TPGLVPGLAG
      1210       1220       1230       1240       1250       1260
SYLCSPLERF LGSVIMRRHL QRIIQQETLQ LINSNEPGVI MFKTDALKCR VALSPKTNQT
      1270       1280       1290       1300       1310       1320
LQLKVTPENA GQWKPDELQV LEKFFETRVA GPPFKANTLI AFTKLLGAPT HILRDCVHIM
      1330       1340       1350       1360       1370       1380
KLELFPDQAT QLKWNVQFCL TIPPSAPPIA PPGTPAVVLK SKMLFFLQLT QKTSVPPQEP
      1390       1400       1410       1420       1430       1440
VSIIVPIIYD MASGTTQQAD IPRQQNSSVA APMMVSNILK RFAEMNPPRQ GECTIFAAVR
      1450
DLMANLTLPP GGRP

Isoforms

Sequence View

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O60244-1-unknown	MAPVQL...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60244-995-	SLISQL...	995		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O60244-995-	SLISQL...	995		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O60244-1102-unknown	PSGRAG...	1102	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000411357
O60244-1289-unknown	VAGPPF...	1289	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000392586

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...PGGRP	1454	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)