TopFIND 4.0

O60427: Acyl-CoA (8-3)-desaturase {ECO:0000305}

General Information

Protein names
- Acyl-CoA (8-3)-desaturase {ECO:0000305}
- 1.14.19.44 {ECO:0000269|PubMed:10601301, ECO:0000269|PubMed:10769175}
- Delta(5) fatty acid desaturase
- D5D {ECO:0000250|UniProtKB:Q920L1}
- Delta(5) desaturase {ECO:0000250|UniProtKB:Q920L1}
- Delta-5 desaturase {ECO:0000303|PubMed:10601301, ECO:0000303|PubMed:10769175}
- Fatty acid desaturase 1 {ECO:0000303|PubMed:10860662}
Gene names FADS1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID O60427

3

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAPDPVAAET AAQGPTPRYF TWDEVAQRSG CEERWLVIDR KVYNISEFTR RHPGGSRVIS 
        70         80         90        100        110        120 
HYAGQDATDP FVAFHINKGL VKKYMNSLLI GELSPEQPSF EPTKNKELTD EFRELRATVE 
       130        140        150        160        170        180 
RMGLMKANHV FFLLYLLHIL LLDGAAWLTL WVFGTSFLPF LLCAVLLSAV QAQAGWLQHD 
       190        200        210        220        230        240 
FGHLSVFSTS KWNHLLHHFV IGHLKGAPAS WWNHMHFQHH AKPNCFRKDP DINMHPFFFA 
       250        260        270        280        290        300 
LGKILSVELG KQKKKYMPYN HQHKYFFLIG PPALLPLYFQ WYIFYFVIQR KKWVDLAWMI 
       310        320        330        340        350        360 
TFYVRFFLTY VPLLGLKAFL GLFFIVRFLE SNWFVWVTQM NHIPMHIDHD RNMDWVSTQL 
       370        380        390        400        410        420 
QATCNVHKSA FNDWFSGHLN FQIEHHLFPT MPRHNYHKVA PLVQSLCAKH GIEYQSKPLL 
       430        440    
SAFADIIHSL KESGQLWLDA YLHQ

Isoforms

- Isoform 2 of Fatty acid desaturase 1 - Isoform 2 of Acyl-CoA (8-3)-desaturase

Sequence View

        10         20         30         40         50         60 
MAPDPVAAET AAQGPTPRYF TWDEVAQRSG CEERWLVIDR KVYNISEFTR RHPGGSRVIS 
        70         80         90        100        110        120 
HYAGQDATDP FVAFHINKGL VKKYMNSLLI GELSPEQPSF EPTKNKELTD EFRELRATVE 
       130        140        150        160        170        180 
RMGLMKANHV FFLLYLLHIL LLDGAAWLTL WVFGTSFLPF LLCAVLLSAV QAQAGWLQHD 
       190        200        210        220        230        240 
FGHLSVFSTS KWNHLLHHFV IGHLKGAPAS WWNHMHFQHH AKPNCFRKDP DINMHPFFFA 
       250        260        270        280        290        300 
LGKILSVELG KQKKKYMPYN HQHKYFFLIG PPALLPLYFQ WYIFYFVIQR KKWVDLAWMI 
       310        320        330        340        350        360 
TFYVRFFLTY VPLLGLKAFL GLFFIVRFLE SNWFVWVTQM NHIPMHIDHD RNMDWVSTQL 
       370        380        390        400        410        420 
QATCNVHKSA FNDWFSGHLN FQIEHHLFPT MPRHNYHKVA PLVQSLCAKH GIEYQSKPLL 
       430        440    
SAFADIIHSL KESGQLWLDA YLHQ         10         20         30         40         50         60 
MAPDPVAAET AAQGPTPRYF TWDEVAQRSG CEERWLVIDR KVYNISEFTR RHPGGSRVIS 
        70         80         90        100        110        120 
HYAGQDATDP FVAFHINKGL VKKYMNSLLI GELSPEQPSF EPTKNKELTD EFRELRATVE 
       130        140        150        160        170        180 
RMGLMKANHV FFLLYLLHIL LLDGAAWLTL WVFGTSFLPF LLCAVLLSAV QAQAGWLQHD 
       190        200        210        220        230        240 
FGHLSVFSTS KWNHLLHHFV IGHLKGAPAS WWNHMHFQHH AKPNCFRKDP DINMHPFFFA 
       250        260        270        280        290        300 
LGKILSVELG KQKKKYMPYN HQHKYFFLIG PPALLPLYFQ WYIFYFVIQR KKWVDLAWMI 
       310        320        330        340        350        360 
TFYVRFFLTY VPLLGLKAFL GLFFIVRFLE SNWFVWVTQM NHIPMHIDHD RNMDWVSTQL 
       370        380        390        400        410        420 
QATCNVHKSA FNDWFSGHLN FQIEHHLFPT MPRHNYHKVA PLVQSLCAKH GIEYQSKPLL 
       430        440    
SAFADIIHSL KESGQLWLDA YLHQ



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Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...AYLHQ 444 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...AYLHQ 444 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt70343

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)