TopFIND 4.0

O60443: Gasdermin-E {ECO:0000305|PubMed:28459430}

General Information

Protein names
- Gasdermin-E {ECO:0000305|PubMed:28459430}
- Inversely correlated with estrogen receptor expression 1
- ICERE-1
- Non-syndromic hearing impairment protein 5 {ECO:0000303|PubMed:9771715}
- Gasdermin-E, N-terminal {ECO:0000303|PubMed:28459430}
- GSDME-NT {ECO:0000303|PubMed:28459430}
- Gasdermin-E, C-terminal {ECO:0000305|PubMed:28459430}
- GSDME-CT {ECO:0000305|PubMed:28459430}
Gene names DFNA5
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID O60443

4

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MFAKATRNFL REVDADGDLI AVSNLNDSDK LQLLSLVTKK KRFWCWQRPK YQFLSLTLGD 
        70         80         90        100        110        120 
VLIEDQFPSP VVVESDFVKY EGKFANHVSG TLETALGKVK LNLGGSSRVE SQSSFGTLRK 
       130        140        150        160        170        180 
QEVDLQQLIR DSAERTINLR NPVLQQVLEG RNEVLCVLTQ KITTMQKCVI SEHMQVEEKC 
       190        200        210        220        230        240 
GGIVGIQTKT VQVSATEDGN VTKDSNVVLE IPAATTIAYG VIELYVKLDG QFEFCLLRGK 
       250        260        270        280        290        300 
QGGFENKKRI DSVYLDPLVF REFAFIDMPD AAHGISSQDG PLSVLKQATL LLERNFHPFA 
       310        320        330        340        350        360 
ELPEPQQTAL SDIFQAVLFD DELLMVLEPV CDDLVSGLSP TVAVLGELKP RQQQDLVAFL 
       370        380        390        400        410        420 
QLVGCSLQGG CPGPEDAGSK QLFMTAYFLV SALAEMPDSA AALLGTCCKL QIIPTLCHLL 
       430        440        450        460        470        480 
RALSDDGVSD LEDPTLTPLK DTERFGIVQR LFASADISLE RLKSSVKAVI LKDSKVFPLL 
       490    
LCITLNGLCA LGREHS

Isoforms

- Isoform 2 of Non-syndromic hearing impairment protein 5 - Isoform 3 of Non-syndromic hearing impairment protein 5 - Isoform 2 of Gasdermin-E - Isoform 3 of Gasdermin-E

Sequence View

        10         20         30         40         50         60 
MFAKATRNFL REVDADGDLI AVSNLNDSDK LQLLSLVTKK KRFWCWQRPK YQFLSLTLGD 
        70         80         90        100        110        120 
VLIEDQFPSP VVVESDFVKY EGKFANHVSG TLETALGKVK LNLGGSSRVE SQSSFGTLRK 
       130        140        150        160        170        180 
QEVDLQQLIR DSAERTINLR NPVLQQVLEG RNEVLCVLTQ KITTMQKCVI SEHMQVEEKC 
       190        200        210        220        230        240 
GGIVGIQTKT VQVSATEDGN VTKDSNVVLE IPAATTIAYG VIELYVKLDG QFEFCLLRGK 
       250        260        270        280        290        300 
QGGFENKKRI DSVYLDPLVF REFAFIDMPD AAHGISSQDG PLSVLKQATL LLERNFHPFA 
       310        320        330        340        350        360 
ELPEPQQTAL SDIFQAVLFD DELLMVLEPV CDDLVSGLSP TVAVLGELKP RQQQDLVAFL 
       370        380        390        400        410        420 
QLVGCSLQGG CPGPEDAGSK QLFMTAYFLV SALAEMPDSA AALLGTCCKL QIIPTLCHLL 
       430        440        450        460        470        480 
RALSDDGVSD LEDPTLTPLK DTERFGIVQR LFASADISLE RLKSSVKAVI LKDSKVFPLL 
       490    
LCITLNGLCA LGREHS         10         20         30         40         50         60 
MFAKATRNFL REVDADGDLI AVSNLNDSDK LQLLSLVTKK KRFWCWQRPK YQFLSLTLGD 
        70         80         90        100        110        120 
VLIEDQFPSP VVVESDFVKY EGKFANHVSG TLETALGKVK LNLGGSSRVE SQSSFGTLRK 
       130        140        150        160        170        180 
QEVDLQQLIR DSAERTINLR NPVLQQVLEG RNEVLCVLTQ KITTMQKCVI SEHMQVEEKC 
       190        200        210        220        230        240 
GGIVGIQTKT VQVSATEDGN VTKDSNVVLE IPAATTIAYG VIELYVKLDG QFEFCLLRGK 
       250        260        270        280        290        300 
QGGFENKKRI DSVYLDPLVF REFAFIDMPD AAHGISSQDG PLSVLKQATL LLERNFHPFA 
       310        320        330        340        350        360 
ELPEPQQTAL SDIFQAVLFD DELLMVLEPV CDDLVSGLSP TVAVLGELKP RQQQDLVAFL 
       370        380        390        400        410        420 
QLVGCSLQGG CPGPEDAGSK QLFMTAYFLV SALAEMPDSA AALLGTCCKL QIIPTLCHLL 
       430        440        450        460        470        480 
RALSDDGVSD LEDPTLTPLK DTERFGIVQR LFASADISLE RLKSSVKAVI LKDSKVFPLL 
       490    
LCITLNGLCA LGREHS         10         20         30         40         50         60 
MFAKATRNFL REVDADGDLI AVSNLNDSDK LQLLSLVTKK KRFWCWQRPK YQFLSLTLGD 
        70         80         90        100        110        120 
VLIEDQFPSP VVVESDFVKY EGKFANHVSG TLETALGKVK LNLGGSSRVE SQSSFGTLRK 
       130        140        150        160        170        180 
QEVDLQQLIR DSAERTINLR NPVLQQVLEG RNEVLCVLTQ KITTMQKCVI SEHMQVEEKC 
       190        200        210        220        230        240 
GGIVGIQTKT VQVSATEDGN VTKDSNVVLE IPAATTIAYG VIELYVKLDG QFEFCLLRGK 
       250        260        270        280        290        300 
QGGFENKKRI DSVYLDPLVF REFAFIDMPD AAHGISSQDG PLSVLKQATL LLERNFHPFA 
       310        320        330        340        350        360 
ELPEPQQTAL SDIFQAVLFD DELLMVLEPV CDDLVSGLSP TVAVLGELKP RQQQDLVAFL 
       370        380        390        400        410        420 
QLVGCSLQGG CPGPEDAGSK QLFMTAYFLV SALAEMPDSA AALLGTCCKL QIIPTLCHLL 
       430        440        450        460        470        480 
RALSDDGVSD LEDPTLTPLK DTERFGIVQR LFASADISLE RLKSSVKAVI LKDSKVFPLL 
       490    
LCITLNGLCA LGREHS         10         20         30         40         50         60 
MFAKATRNFL REVDADGDLI AVSNLNDSDK LQLLSLVTKK KRFWCWQRPK YQFLSLTLGD 
        70         80         90        100        110        120 
VLIEDQFPSP VVVESDFVKY EGKFANHVSG TLETALGKVK LNLGGSSRVE SQSSFGTLRK 
       130        140        150        160        170        180 
QEVDLQQLIR DSAERTINLR NPVLQQVLEG RNEVLCVLTQ KITTMQKCVI SEHMQVEEKC 
       190        200        210        220        230        240 
GGIVGIQTKT VQVSATEDGN VTKDSNVVLE IPAATTIAYG VIELYVKLDG QFEFCLLRGK 
       250        260        270        280        290        300 
QGGFENKKRI DSVYLDPLVF REFAFIDMPD AAHGISSQDG PLSVLKQATL LLERNFHPFA 
       310        320        330        340        350        360 
ELPEPQQTAL SDIFQAVLFD DELLMVLEPV CDDLVSGLSP TVAVLGELKP RQQQDLVAFL 
       370        380        390        400        410        420 
QLVGCSLQGG CPGPEDAGSK QLFMTAYFLV SALAEMPDSA AALLGTCCKL QIIPTLCHLL 
       430        440        450        460        470        480 
RALSDDGVSD LEDPTLTPLK DTERFGIVQR LFASADISLE RLKSSVKAVI LKDSKVFPLL 
       490    
LCITLNGLCA LGREHS



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

4 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)