O60443: Gasdermin-E {ECO:0000305|PubMed:28459430}
Protein names | - Gasdermin-E {ECO:0000305|PubMed:28459430} - Inversely correlated with estrogen receptor expression 1 - ICERE-1 - Non-syndromic hearing impairment protein 5 {ECO:0000303|PubMed:9771715} - Gasdermin-E, N-terminal {ECO:0000303|PubMed:28459430} - GSDME-NT {ECO:0000303|PubMed:28459430} - Gasdermin-E, C-terminal {ECO:0000305|PubMed:28459430} - GSDME-CT {ECO:0000305|PubMed:28459430} |
---|---|
Gene names | DFNA5 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | O60443 |
4
N-termini
1
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MFAKATRNFL REVDADGDLI AVSNLNDSDK LQLLSLVTKK KRFWCWQRPK YQFLSLTLGD
70 80 90 100 110 120
VLIEDQFPSP VVVESDFVKY EGKFANHVSG TLETALGKVK LNLGGSSRVE SQSSFGTLRK
130 140 150 160 170 180
QEVDLQQLIR DSAERTINLR NPVLQQVLEG RNEVLCVLTQ KITTMQKCVI SEHMQVEEKC
190 200 210 220 230 240
GGIVGIQTKT VQVSATEDGN VTKDSNVVLE IPAATTIAYG VIELYVKLDG QFEFCLLRGK
250 260 270 280 290 300
QGGFENKKRI DSVYLDPLVF REFAFIDMPD AAHGISSQDG PLSVLKQATL LLERNFHPFA
310 320 330 340 350 360
ELPEPQQTAL SDIFQAVLFD DELLMVLEPV CDDLVSGLSP TVAVLGELKP RQQQDLVAFL
370 380 390 400 410 420
QLVGCSLQGG CPGPEDAGSK QLFMTAYFLV SALAEMPDSA AALLGTCCKL QIIPTLCHLL
430 440 450 460 470 480
RALSDDGVSD LEDPTLTPLK DTERFGIVQR LFASADISLE RLKSSVKAVI LKDSKVFPLL
490
LCITLNGLCA LGREHS
Isoforms
- Isoform 2 of Non-syndromic hearing impairment protein 5 - Isoform 3 of Non-syndromic hearing impairment protein 5 - Isoform 2 of Gasdermin-E - Isoform 3 of Gasdermin-ESequence View
10 20 30 40 50 60
MFAKATRNFL REVDADGDLI AVSNLNDSDK LQLLSLVTKK KRFWCWQRPK YQFLSLTLGD
70 80 90 100 110 120
VLIEDQFPSP VVVESDFVKY EGKFANHVSG TLETALGKVK LNLGGSSRVE SQSSFGTLRK
130 140 150 160 170 180
QEVDLQQLIR DSAERTINLR NPVLQQVLEG RNEVLCVLTQ KITTMQKCVI SEHMQVEEKC
190 200 210 220 230 240
GGIVGIQTKT VQVSATEDGN VTKDSNVVLE IPAATTIAYG VIELYVKLDG QFEFCLLRGK
250 260 270 280 290 300
QGGFENKKRI DSVYLDPLVF REFAFIDMPD AAHGISSQDG PLSVLKQATL LLERNFHPFA
310 320 330 340 350 360
ELPEPQQTAL SDIFQAVLFD DELLMVLEPV CDDLVSGLSP TVAVLGELKP RQQQDLVAFL
370 380 390 400 410 420
QLVGCSLQGG CPGPEDAGSK QLFMTAYFLV SALAEMPDSA AALLGTCCKL QIIPTLCHLL
430 440 450 460 470 480
RALSDDGVSD LEDPTLTPLK DTERFGIVQR LFASADISLE RLKSSVKAVI LKDSKVFPLL
490
LCITLNGLCA LGREHS
10 20 30 40 50 60
MFAKATRNFL REVDADGDLI AVSNLNDSDK LQLLSLVTKK KRFWCWQRPK YQFLSLTLGD
70 80 90 100 110 120
VLIEDQFPSP VVVESDFVKY EGKFANHVSG TLETALGKVK LNLGGSSRVE SQSSFGTLRK
130 140 150 160 170 180
QEVDLQQLIR DSAERTINLR NPVLQQVLEG RNEVLCVLTQ KITTMQKCVI SEHMQVEEKC
190 200 210 220 230 240
GGIVGIQTKT VQVSATEDGN VTKDSNVVLE IPAATTIAYG VIELYVKLDG QFEFCLLRGK
250 260 270 280 290 300
QGGFENKKRI DSVYLDPLVF REFAFIDMPD AAHGISSQDG PLSVLKQATL LLERNFHPFA
310 320 330 340 350 360
ELPEPQQTAL SDIFQAVLFD DELLMVLEPV CDDLVSGLSP TVAVLGELKP RQQQDLVAFL
370 380 390 400 410 420
QLVGCSLQGG CPGPEDAGSK QLFMTAYFLV SALAEMPDSA AALLGTCCKL QIIPTLCHLL
430 440 450 460 470 480
RALSDDGVSD LEDPTLTPLK DTERFGIVQR LFASADISLE RLKSSVKAVI LKDSKVFPLL
490
LCITLNGLCA LGREHS
10 20 30 40 50 60
MFAKATRNFL REVDADGDLI AVSNLNDSDK LQLLSLVTKK KRFWCWQRPK YQFLSLTLGD
70 80 90 100 110 120
VLIEDQFPSP VVVESDFVKY EGKFANHVSG TLETALGKVK LNLGGSSRVE SQSSFGTLRK
130 140 150 160 170 180
QEVDLQQLIR DSAERTINLR NPVLQQVLEG RNEVLCVLTQ KITTMQKCVI SEHMQVEEKC
190 200 210 220 230 240
GGIVGIQTKT VQVSATEDGN VTKDSNVVLE IPAATTIAYG VIELYVKLDG QFEFCLLRGK
250 260 270 280 290 300
QGGFENKKRI DSVYLDPLVF REFAFIDMPD AAHGISSQDG PLSVLKQATL LLERNFHPFA
310 320 330 340 350 360
ELPEPQQTAL SDIFQAVLFD DELLMVLEPV CDDLVSGLSP TVAVLGELKP RQQQDLVAFL
370 380 390 400 410 420
QLVGCSLQGG CPGPEDAGSK QLFMTAYFLV SALAEMPDSA AALLGTCCKL QIIPTLCHLL
430 440 450 460 470 480
RALSDDGVSD LEDPTLTPLK DTERFGIVQR LFASADISLE RLKSSVKAVI LKDSKVFPLL
490
LCITLNGLCA LGREHS
10 20 30 40 50 60
MFAKATRNFL REVDADGDLI AVSNLNDSDK LQLLSLVTKK KRFWCWQRPK YQFLSLTLGD
70 80 90 100 110 120
VLIEDQFPSP VVVESDFVKY EGKFANHVSG TLETALGKVK LNLGGSSRVE SQSSFGTLRK
130 140 150 160 170 180
QEVDLQQLIR DSAERTINLR NPVLQQVLEG RNEVLCVLTQ KITTMQKCVI SEHMQVEEKC
190 200 210 220 230 240
GGIVGIQTKT VQVSATEDGN VTKDSNVVLE IPAATTIAYG VIELYVKLDG QFEFCLLRGK
250 260 270 280 290 300
QGGFENKKRI DSVYLDPLVF REFAFIDMPD AAHGISSQDG PLSVLKQATL LLERNFHPFA
310 320 330 340 350 360
ELPEPQQTAL SDIFQAVLFD DELLMVLEPV CDDLVSGLSP TVAVLGELKP RQQQDLVAFL
370 380 390 400 410 420
QLVGCSLQGG CPGPEDAGSK QLFMTAYFLV SALAEMPDSA AALLGTCCKL QIIPTLCHLL
430 440 450 460 470 480
RALSDDGVSD LEDPTLTPLK DTERFGIVQR LFASADISLE RLKSSVKAVI LKDSKVFPLL
490
LCITLNGLCA LGREHS
Protein Neighborhood
Domains & Features
4 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
O60443-1-acetylation | MFAKAT... | 1 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
O60443-1-unknown | MFAKAT... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
O60443-165-unknown | MQKCVI... | 165 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt72662 | |||
O60443-396-unknown | MPDSAA... | 396 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt72661 | |||
O60443-396-unknown | MPDSAA... | 396 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt107806 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...GREHS | 496 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...GREHS | 496 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt68279 | |||
...GREHS | 496 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt68280 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|