O60476: Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

General Information

Protein names	- Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB - 3.2.1.113 {ECO:0000250\|UniProtKB:P32906} - Mannosidase alpha class 1A member 2 - Processing alpha-1,2-mannosidase IB - Alpha-1,2-mannosidase IB
Gene names	MAN1A2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O60476

3 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTTPALLPLS GRRIPPLNLG PPSFPHHRAT LRLSEKFILL LILSAFITLC FGAFFFLPDS
        70         80         90        100        110        120
SKHKRFDLGL EDVLIPHVDA GKGAKNPGVF LIHGPDEHRH REEEERLRNK IRADHEKALE
       130        140        150        160        170        180
EAKEKLRKSR EEIRAEIQTE KNKVVQEMKI KENKPLPPVP IPNLVGIRGG DPEDNDIREK
       190        200        210        220        230        240
REKIKEMMKH AWDNYRTYGW GHNELRPIAR KGHSPNIFGS SQMGATIVDA LDTLYIMGLH
       250        260        270        280        290        300
DEFLDGQRWI EDNLDFSVNS EVSVFEVNIR FIGGLLAAYY LSGEEIFKIK AVQLAEKLLP
       310        320        330        340        350        360
AFNTPTGIPW AMVNLKSGVG RNWGWASAGS SILAEFGTLH MEFIHLSYLT GDLTYYKKVM
       370        380        390        400        410        420
HIRKLLQKMD RPNGLYPNYL NPRTGRWGQY HTSVGGLGDS FYEYLLKAWL MSDKTDHEAR
       430        440        450        460        470        480
KMYDDAIEAI EKHLIKKSRG GLTFIGEWKN GHLEKKMGHL ACFAGGMFAL GADGSRADKA
       490        500        510        520        530        540
GHYLELGAEI ARTCHESYDR TALKLGPESF KFDGAVEAVA VRQAEKYYIL RPEVIETYWY
       550        560        570        580        590        600
LWRFTHDPRY RQWGWEAALA IEKYCRVNGG FSGVKDVYSS TPTHDDVQQS FFLAETLKYL
       610        620        630        640
YLLFSGDDLL PLDHWVFNTE AHPLPVLHLA NTTLSGNPAV R

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O60476-2-unknown	MTTPAL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60476-2-Acetylation	TTPALL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60476-2-Acetylation	TTPALL...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
O60476-2-Acetylation	TTPALL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O60476-562-unknown	EKYCRV...	562		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000402416

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...NPAVR	641	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)