O60488: Long-chain-fatty-acid--CoA ligase 4

General Information

Protein names	- Long-chain-fatty-acid--CoA ligase 4 - 6.2.1.3 - Long-chain acyl-CoA synthetase 4 - LACS 4
Gene names	ACSL4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O60488

11 N-termini

7 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKLKLNVLTI ILLPVHLLIT IYSALIFIPW YFLTNAKKKN AMAKRIKAKP TSDKPGSPYR
        70         80         90        100        110        120
SVTHFDSLAV IDIPGADTLD KLFDHAVSKF GKKDSLGTRE ILSEENEMQP NGKVFKKLIL
       130        140        150        160        170        180
GNYKWMNYLE VNRRVNNFGS GLTALGLKPK NTIAIFCETR AEWMIAAQTC FKYNFPLVTL
       190        200        210        220        230        240
YATLGKEAVV HGLNESEASY LITSVELLES KLKTALLDIS CVKHIIYVDN KAINKAEYPE
       250        260        270        280        290        300
GFEIHSMQSV EELGSNPENL GIPPSRPTPS DMAIVMYTSG STGRPKGVMM HHSNLIAGMT
       310        320        330        340        350        360
GQCERIPGLG PKDTYIGYLP LAHVLELTAE ISCFTYGCRI GYSSPLTLSD QSSKIKKGSK
       370        380        390        400        410        420
GDCTVLKPTL MAAVPEIMDR IYKNVMSKVQ EMNYIQKTLF KIGYDYKLEQ IKKGYDAPLC
       430        440        450        460        470        480
NLLLFKKVKA LLGGNVRMML SGGAPLSPQT HRFMNVCFCC PIGQGYGLTE SCGAGTVTEV
       490        500        510        520        530        540
TDYTTGRVGA PLICCEIKLK DWQEGGYTIN DKPNPRGEIV IGGQNISMGY FKNEEKTAED
       550        560        570        580        590        600
YSVDENGQRW FCTGDIGEFH PDGCLQIIDR KKDLVKLQAG EYVSLGKVEA ALKNCPLIDN
       610        620        630        640        650        660
ICAFAKSDQS YVISFVVPNQ KRLTLLAQQK GVEGTWVDIC NNPAMEAEIL KEIREAANAM
       670        680        690        700        710
KLERFEIPIK VRLSPEPWTP ETGLVTDAFK LKRKELRNHY LKDIERMYGG K

Isoforms

- Isoform Short of Long-chain-fatty-acid--CoA ligase 4

Sequence View

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Protein Neighborhood

Domains & Features

11 N-termini - 7 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O60488-1-unknown	MKLKLN...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60488-42-unknown	MAKRIK...	42	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt66206
O60488-42-unknown	MAKRIK...	42	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000262835
O60488-42-unknown	MAKRIK...	42	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000424808
O60488-61-	SVTHFD...	61		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O60488-61-unknown	SVTHFD...	61	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177675
O60488-67-	SLAVID...	67		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O60488-67-unknown	SLAVID...	67	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177673
O60488-438-	MMLSGG...	438		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O60488-438-unknown	MMLSGG...	438	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177677
O60488-473-	GAGTVT...	473		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O60488-473-unknown	GAGTVT...	473	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177671
O60488-563-unknown	GCLQII...	563	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1112
O60488-563-unknown	GCLQII...	563	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153639

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PTSDKP	54	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000423077
...NYKWMN	126	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000421425
...NYKWMN	126	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154703
...KWMNYL	128	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000425378
...KWMNYL	128	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154709
...GLTALG	145	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000425408
...GLTALG	145	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154906
...HGLNES	195	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000424808
...HGLNES	195	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155565
...EFHPDG	562	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1112
...EFHPDG	562	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137063
...MYGGK	711	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...MYGGK	711	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61824

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP1_HUMAN	562	HPDG.\|.GCLQ	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)