TopFIND 4.0

O60565: Gremlin-1

General Information

Protein names
- Gremlin-1
- Cell proliferation-inducing gene 2 protein
- Cysteine knot superfamily 1, BMP antagonist 1
- DAN domain family member 2
- Down-regulated in Mos-transformed cells protein
- Increased in high glucose protein 2 {ECO:0000303|PubMed:10744662}
- IHG-2 {ECO:0000303|PubMed:10744662}
Gene names GREM1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID O60565

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MSRTAYTVGA LLLLLGTLLP AAEGKKKGSQ GAIPPPDKAQ HNDSEQTQSP QQPGSRNRGR 
        70         80         90        100        110        120 
GQGRGTAMPG EEVLESSQEA LHVTERKYLK RDWCKTQPLK QTIHEEGCNS RTIINRFCYG 
       130        140        150        160        170        180 
QCNSFYIPRH IRKEEGSFQS CSFCKPKKFT TMMVTLNCPE LQPPTKKKRV TRVKQCRCIS 
   
IDLD

Isoforms

- Isoform 2 of Gremlin-1

Sequence View

        10         20         30         40         50         60 
MSRTAYTVGA LLLLLGTLLP AAEGKKKGSQ GAIPPPDKAQ HNDSEQTQSP QQPGSRNRGR 
        70         80         90        100        110        120 
GQGRGTAMPG EEVLESSQEA LHVTERKYLK RDWCKTQPLK QTIHEEGCNS RTIINRFCYG 
       130        140        150        160        170        180 
QCNSFYIPRH IRKEEGSFQS CSFCKPKKFT TMMVTLNCPE LQPPTKKKRV TRVKQCRCIS 
   
IDLD



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Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    O60565-1-unknown MSRTAY... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt76421
    O60565-25-unknown KKKGSQ... 25 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...SIDLD 184 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...SIDLD 184 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt72039

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)