O60733: 85/88 kDa calcium-independent phospholipase A2

General Information

Protein names	- 85/88 kDa calcium-independent phospholipase A2 - CaI-PLA2 - 3.1.1.4 - Group VI phospholipase A2 - GVI PLA2 - Intracellular membrane-associated calcium-independent phospholipase A2 beta - iPLA2-beta - Patatin-like phospholipase domain-containing protein 9 - PNPLA9
Gene names	PLA2G6
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O60733

2 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform SH-iPLA2 of 85/88 kDa calcium-independent phospholipase A2 - Isoform Ankyrin-iPLA2-1 of 85/88 kDa calcium-independent phospholipase A2 - Isoform Ankyrin-iPLA2-2 of 85/88 kDa calcium-independent phospholipase A2

Sequence View

        10         20         30         40         50         60
MQFFGRLVNT FSGVTNLFSN PFRVKEVAVA DYTSSDRVRE EGQLILFQNT PNRTWDCVLV
        70         80         90        100        110        120
NPRNSQSGFR LFQLELEADA LVNFHQYSSQ LLPFYESSPQ VLHTEVLQHL TDLIRNHPSW
       130        140        150        160        170        180
SVAHLAVELG IRECFHHSRI ISCANCAENE EGCTPLHLAC RKGDGEILVE LVQYCHTQMD
       190        200        210        220        230        240
VTDYKGETVF HYAVQGDNSQ VLQLLGRNAV AGLNQVNNQG LTPLHLACQL GKQEMVRVLL
       250        260        270        280        290        300
LCNARCNIMG PNGYPIHSAM KFSQKGCAEM IISMDSSQIH SKDPRYGASP LHWAKNAEMA
       310        320        330        340        350        360
RMLLKRGCNV NSTSSAGNTA LHVAVMRNRF DCAIVLLTHG ANADARGEHG NTPLHLAMSK
       370        380        390        400        410        420
DNVEMIKALI VFGAEVDTPN DFGETPTFLA SKIGRLVTRK AILTLLRTVG AEYCFPPIHG
       430        440        450        460        470        480
VPAEQGSAAP HHPFSLERAQ PPPISLNNLE LQDLMHISRA RKPAFILGSM RDEKRTHDHL
       490        500        510        520        530        540
LCLDGGGVKG LIIIQLLIAI EKASGVATKD LFDWVAGTST GGILALAILH SKSMAYMRGM
       550        560        570        580        590        600
YFRMKDEVFR GSRPYESGPL EEFLKREFGE HTKMTDVRKP KVMLTGTLSD RQPAELHLFR
       610        620        630        640        650        660
NYDAPETVRE PRFNQNVNLR PPAQPSDQLV WRAARSSGAA PTYFRPNGRF LDGGLLANNP
       670        680        690        700        710        720
TLDAMTEIHE YNQDLIRKGQ ANKVKKLSIV VSLGTGRSPQ VPVTCVDVFR PSNPWELAKT
       730        740        750        760        770        780
VFGAKELGKM VVDCCTDPDG RAVDRARAWC EMVGIQYFRL NPQLGTDIML DEVSDTVLVN
       790        800
ALWETEVYIY EHREEFQKLI QLLLSP         10         20         30         40         50         60
MQFFGRLVNT FSGVTNLFSN PFRVKEVAVA DYTSSDRVRE EGQLILFQNT PNRTWDCVLV
        70         80         90        100        110        120
NPRNSQSGFR LFQLELEADA LVNFHQYSSQ LLPFYESSPQ VLHTEVLQHL TDLIRNHPSW
       130        140        150        160        170        180
SVAHLAVELG IRECFHHSRI ISCANCAENE EGCTPLHLAC RKGDGEILVE LVQYCHTQMD
       190        200        210        220        230        240
VTDYKGETVF HYAVQGDNSQ VLQLLGRNAV AGLNQVNNQG LTPLHLACQL GKQEMVRVLL
       250        260        270        280        290        300
LCNARCNIMG PNGYPIHSAM KFSQKGCAEM IISMDSSQIH SKDPRYGASP LHWAKNAEMA
       310        320        330        340        350        360
RMLLKRGCNV NSTSSAGNTA LHVAVMRNRF DCAIVLLTHG ANADARGEHG NTPLHLAMSK
       370        380        390        400        410        420
DNVEMIKALI VFGAEVDTPN DFGETPTFLA SKIGRLVTRK AILTLLRTVG AEYCFPPIHG
       430        440        450        460        470        480
VPAEQGSAAP HHPFSLERAQ PPPISLNNLE LQDLMHISRA RKPAFILGSM RDEKRTHDHL
       490        500        510        520        530        540
LCLDGGGVKG LIIIQLLIAI EKASGVATKD LFDWVAGTST GGILALAILH SKSMAYMRGM
       550        560        570        580        590        600
YFRMKDEVFR GSRPYESGPL EEFLKREFGE HTKMTDVRKP KVMLTGTLSD RQPAELHLFR
       610        620        630        640        650        660
NYDAPETVRE PRFNQNVNLR PPAQPSDQLV WRAARSSGAA PTYFRPNGRF LDGGLLANNP
       670        680        690        700        710        720
TLDAMTEIHE YNQDLIRKGQ ANKVKKLSIV VSLGTGRSPQ VPVTCVDVFR PSNPWELAKT
       730        740        750        760        770        780
VFGAKELGKM VVDCCTDPDG RAVDRARAWC EMVGIQYFRL NPQLGTDIML DEVSDTVLVN
       790        800
ALWETEVYIY EHREEFQKLI QLLLSP         10         20         30         40         50         60
MQFFGRLVNT FSGVTNLFSN PFRVKEVAVA DYTSSDRVRE EGQLILFQNT PNRTWDCVLV
        70         80         90        100        110        120
NPRNSQSGFR LFQLELEADA LVNFHQYSSQ LLPFYESSPQ VLHTEVLQHL TDLIRNHPSW
       130        140        150        160        170        180
SVAHLAVELG IRECFHHSRI ISCANCAENE EGCTPLHLAC RKGDGEILVE LVQYCHTQMD
       190        200        210        220        230        240
VTDYKGETVF HYAVQGDNSQ VLQLLGRNAV AGLNQVNNQG LTPLHLACQL GKQEMVRVLL
       250        260        270        280        290        300
LCNARCNIMG PNGYPIHSAM KFSQKGCAEM IISMDSSQIH SKDPRYGASP LHWAKNAEMA
       310        320        330        340        350        360
RMLLKRGCNV NSTSSAGNTA LHVAVMRNRF DCAIVLLTHG ANADARGEHG NTPLHLAMSK
       370        380        390        400        410        420
DNVEMIKALI VFGAEVDTPN DFGETPTFLA SKIGRLVTRK AILTLLRTVG AEYCFPPIHG
       430        440        450        460        470        480
VPAEQGSAAP HHPFSLERAQ PPPISLNNLE LQDLMHISRA RKPAFILGSM RDEKRTHDHL
       490        500        510        520        530        540
LCLDGGGVKG LIIIQLLIAI EKASGVATKD LFDWVAGTST GGILALAILH SKSMAYMRGM
       550        560        570        580        590        600
YFRMKDEVFR GSRPYESGPL EEFLKREFGE HTKMTDVRKP KVMLTGTLSD RQPAELHLFR
       610        620        630        640        650        660
NYDAPETVRE PRFNQNVNLR PPAQPSDQLV WRAARSSGAA PTYFRPNGRF LDGGLLANNP
       670        680        690        700        710        720
TLDAMTEIHE YNQDLIRKGQ ANKVKKLSIV VSLGTGRSPQ VPVTCVDVFR PSNPWELAKT
       730        740        750        760        770        780
VFGAKELGKM VVDCCTDPDG RAVDRARAWC EMVGIQYFRL NPQLGTDIML DEVSDTVLVN
       790        800
ALWETEVYIY EHREEFQKLI QLLLSP

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O60733-1-unknown	MQFFGR...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O60733-1-unknown	MQFFGR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85609
O60733-1-unknown	MQFFGR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85610
O60733-1-unknown	MQFFGR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85611
O60733-184-unknown	YKGETV...	184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1468
O60733-184-unknown	YKGETV...	184	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143083
O60733-184-unknown	YKGETV...	184	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146043
O60733-184-unknown	YKGETV...	184	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146044

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MDVTDY	183	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1468
...MDVTDY	183	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126302
...MDVTDY	183	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129342
...MDVTDY	183	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129343
...LLLSP	806	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LLLSP	806	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81227

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	183	VTDY.\|.YKGE	inferred from experiment	unknown	MEROPS	Kudo I	Atsumi G et al.:Fas-induced arachidonic acid re... (C14.003)	9593733,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)