TopFIND 4.0

O60825: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

General Information

Protein names
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
- 6PF-2-K/Fru-2,6-P2ase 2
- PFK/FBPase 2
- 6PF-2-K/Fru-2,6-P2ase heart-type isozyme
- 6-phosphofructo-2-kinase
- 2.7.1.105
- Fructose-2,6-bisphosphatase
- 3.1.3.46
Gene names PFKFB2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID O60825

3

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MSGASSSEQN NNSYETKTPN LRMSEKKCSW ASYMTNSPTL IVMIGLPARG KTYVSKKLTR 
        70         80         90        100        110        120 
YLNWIGVPTK VFNLGVYRRE AVKSYKSYDF FRHDNEEAMK IRKQCALVAL EDVKAYLTEE 
       130        140        150        160        170        180 
NGQIAVFDAT NTTRERRDMI LNFAEQNSFK VFFVESVCDD PDVIAANILE VKVSSPDYPE 
       190        200        210        220        230        240 
RNRENVMEDF LKRIECYKVT YRPLDPDNYD KDLSFIKVIN VGQRFLVNRV QDYIQSKIVY 
       250        260        270        280        290        300 
YLMNIHVQPR TIYLCRHGES EFNLLGKIGG DSGLSVRGKQ FAQALRKFLE EQEITDLKVW 
       310        320        330        340        350        360 
TSQLKRTIQT AESLGVPYEQ WKILNEIDAG VCEEMTYAEI EKRYPEEFAL RDQEKYLYRY 
       370        380        390        400        410        420 
PGGESYQDLV QRLEPVIMEL ERQGNVLVIS HQAVMRCLLA YFLDKGADEL PYLRCPLHTI 
       430        440        450        460        470        480 
FKLTPVAYGC KVETIKLNVE AVNTHRDKPT NNFPKNQTPV RMRRNSFTPL SSSNTIRRPR 
       490        500    
NYSVGSRPLK PLSPLRAQDM QEGAD

Isoforms

- Isoform 2 of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

Sequence View

        10         20         30         40         50         60 
MSGASSSEQN NNSYETKTPN LRMSEKKCSW ASYMTNSPTL IVMIGLPARG KTYVSKKLTR 
        70         80         90        100        110        120 
YLNWIGVPTK VFNLGVYRRE AVKSYKSYDF FRHDNEEAMK IRKQCALVAL EDVKAYLTEE 
       130        140        150        160        170        180 
NGQIAVFDAT NTTRERRDMI LNFAEQNSFK VFFVESVCDD PDVIAANILE VKVSSPDYPE 
       190        200        210        220        230        240 
RNRENVMEDF LKRIECYKVT YRPLDPDNYD KDLSFIKVIN VGQRFLVNRV QDYIQSKIVY 
       250        260        270        280        290        300 
YLMNIHVQPR TIYLCRHGES EFNLLGKIGG DSGLSVRGKQ FAQALRKFLE EQEITDLKVW 
       310        320        330        340        350        360 
TSQLKRTIQT AESLGVPYEQ WKILNEIDAG VCEEMTYAEI EKRYPEEFAL RDQEKYLYRY 
       370        380        390        400        410        420 
PGGESYQDLV QRLEPVIMEL ERQGNVLVIS HQAVMRCLLA YFLDKGADEL PYLRCPLHTI 
       430        440        450        460        470        480 
FKLTPVAYGC KVETIKLNVE AVNTHRDKPT NNFPKNQTPV RMRRNSFTPL SSSNTIRRPR 
       490        500    
NYSVGSRPLK PLSPLRAQDM QEGAD



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Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...QEGAD 505 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)