O60927: E3 ubiquitin-protein ligase PPP1R11 {ECO:0000303|PubMed:27805901}

General Information

Protein names	- E3 ubiquitin-protein ligase PPP1R11 {ECO:0000303\|PubMed:27805901} - 2.3.2.27 - Hemochromatosis candidate gene V protein - HCG V - Protein phosphatase 1 regulatory subunit 11 - Protein phosphatase inhibitor 3
Gene names	PPP1R11
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O60927

4 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAEAGAGLSE TVTETTVTVT TEPENRSLTI KLRKRKPEKK VEWTSDTVDN EHMGRRSSKC
        70         80         90        100        110        120
CCIYEKPRAF GESSTESDEE EEEGCGHTHC VRGHRKGRRR ATLGPTPTTP PQPPDPSQPP

PGPMQH

Isoforms

Sequence View

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Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O60927-2-unknown	MAEAGA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60927-2-Acetylation	AEAGAG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60927-2-Acetylation	AEAGAG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O60927-2-Acetylation	AEAGAG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O60927-50-unknown	NEHMGR...	50		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1474
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000391581
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000414471
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000390548
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000401267
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000406410
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000383499
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000383498
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000383497
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000383496
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000383495
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000399222
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000412526
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000400589
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000406648
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000409066
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000411693
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000408173
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000416038
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000415651
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000399167
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000365964
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000365960
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000365956
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000365954
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000365949
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000397132
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000390917
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000411976
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000396522
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000399723
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000392044
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000400763
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000404824
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000399965
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000392260
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000404779
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000398205
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000410429
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000403611
O60927-53-unknown	MGRRSS...	53		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000388044

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...SDTVDN	49	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1474
...GPMQH	126	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...GPMQH	126		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...GPMQH	126		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	49	TVDN.\|.NEHM	inferred from experiment	unknown	MEROPS	Lee EY	Huang HS et al.:Protein phosphatase-1 inhibitor... (C14.003)	18450750,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)