O60934: Nibrin

General Information

Protein names	- Nibrin - Cell cycle regulatory protein p95 - Nijmegen breakage syndrome protein 1
Gene names	NBN
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O60934

4 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MWKLLPAAGP AGGEPYRLLT GVEYVVGRKN CAILIENDQS ISRNHAVLTA NFSVTNLSQT
        70         80         90        100        110        120
DEIPVLTLKD NSKYGTFVNE EKMQNGFSRT LKSGDGITFG VFGSKFRIEY EPLVACSSCL
       130        140        150        160        170        180
DVSGKTALNQ AILQLGGFTV NNWTEECTHL VMVSVKVTIK TICALICGRP IVKPEYFTEF
       190        200        210        220        230        240
LKAVESKKQP PQIESFYPPL DEPSIGSKNV DLSGRQERKQ IFKGKTFIFL NAKQHKKLSS
       250        260        270        280        290        300
AVVFGGGEAR LITEENEEEH NFFLAPGTCV VDTGITNSQT LIPDCQKKWI QSIMDMLQRQ
       310        320        330        340        350        360
GLRPIPEAEI GLAVIFMTTK NYCDPQGHPS TGLKTTTPGP SLSQGVSVDE KLMPSAPVNT
       370        380        390        400        410        420
TTYVADTESE QADTWDLSER PKEIKVSKME QKFRMLSQDA PTVKESCKTS SNNNSMVSNT
       430        440        450        460        470        480
LAKMRIPNYQ LSPTKLPSIN KSKDRASQQQ QTNSIRNYFQ PSTKKRERDE ENQEMSSCKS
       490        500        510        520        530        540
ARIETSCSLL EQTQPATPSL WKNKEQHLSE NEPVDTNSDN NLFTDTDLKS IVKNSASKSH
       550        560        570        580        590        600
AAEKLRSNKK REMDDVAIED EVLEQLFKDT KPELEIDVKV QKQEEDVNVR KRPRMDIETN
       610        620        630        640        650        660
DTFSDEAVPE SSKISQENEI GKKRELKEDS LWSAKEISNN DKLQDDSEML PKKLLLTEFR
       670        680        690        700        710        720
SLVIKNSTSR NPSGINDDYG QLKNFKKFKK VTYPGAGKLP HIIGGSDLIA HHARKNTELE
       730        740        750
EWLRQEMEVQ NQHAKEESLA DDLFRYNPYL KRRR

Isoforms

Sequence View

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Evidence Codes:

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Evidence Names:

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O60934-1-acetylation	MWKLLP...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O60934-1-unknown	MWKLLP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60934-83-unknown	MQNGFS...	83		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000386924
O60934-83-unknown	MQNGFS...	83		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000428717
O60934-83-unknown	MQNGFS...	83		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000429971
O60934-488-	SLLEQT...	488			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PIVKPE	174	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000429971
...VVFGGG	246	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428717
...VFGGGE	247	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000430983
...LKRRR	754	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)