O70157: DNA topoisomerase 3-alpha

General Information

Protein names	- DNA topoisomerase 3-alpha - 5.6.2.2 {ECO:0000255\|PROSITE-ProRule:PRU10131} - DNA topoisomerase III alpha
Gene names	Top3a
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	O70157

2 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MIFPVTLLAF QWHRRPGGRA LSRAAMEVAF RGVRKVLCVA EKNDAAKGIA DLLSNGRMRR
        70         80         90        100        110        120
KEGLSKFNKI YEFDYHLYGQ NVTMIMTSVS GHLLAHDFQM QFRKWQSCNP LVLFEAEIEK
       130        140        150        160        170        180
YCPENFIDIK KTLERETHHC QALVIWTDCD REGENIGFEI IHVCKAVKPN LRVLRARFSE
       190        200        210        220        230        240
ITPHAVRTAC ENLTEPDQRV SDAVDVRQEL DLRIGAAFTR FQTLRLQRIF PEVLAEQLIS
       250        260        270        280        290        300
YGSCQFPTLG FVVERFKAIQ AFVPEVFHKI KVTHDHKDGT VEFNWKRYRL FNHTACLVLY
       310        320        330        340        350        360
QLCMEDPMAT VVEVRSKPKS KWRPQALDTV ELEKLASRKL RINAKETMRI AEKLYTQGYI
       370        380        390        400        410        420
SYPRTETNIF PKDLNLVALV EQQTVDPHWG AFAQTILERG GPTPRNGSKS DQAHPPIHPT
       430        440        450        460        470        480
KYTSGLQGDD RRLYEFIVRH FLACCSQDAQ GQETTVEIDI AQERFVAHGL IILARNYLDV
       490        500        510        520        530        540
YPYDHWSDKL LPVYEQGSHF QPSTVEMVDG ETSPPQLLTE ADLIALMEKH GIGTDATHAE
       550        560        570        580        590        600
HIETIKARMY VGLTSDKRFL PGHLGMGLVE GYDSMGYEMS KPDLRAELEA DLKLICEGKK
       610        620        630        640        650        660
DKFQVLRQQV QKYKQVFIEA VAKAKKLDEA LSQYLGERTE MAQQEEIYPA MPEPVRKCPQ
       670        680        690        700        710        720
CNKDMVLKTK KSGGFYLSCM GFPECRSAVW FPDSVLEASR DNSVCSVCQP PPVYRLKLKF
       730        740        750        760        770        780
KRGSLPPAMP LEFVGCIGGC DETLKEIFGL RFPRALPRAS QPSGHLQASQ ALNRMDSSQH
       790        800        810        820        830        840
NLSQPLVNRH TRPSKTVAQA LLPPTTAGES NSVTCNCGRE AVLLTVRKQG PNQGRHFYKC
       850        860        870        880        890        900
SNGDCNFFLW ADSSHSTGGG TPTSASGPPG SSVGCPSSVG SHMDGFGSLG SDSDGGTPCL
       910        920        930        940        950        960
CGQPAVTRTV QKDGPNKGRQ FHTCAKPREQ QCGFFQWVDE NVAPGSFAAP AWPGGRGKAQ
       970        980        990       1000
RPEAASKRPR AGSSDAGSTV KKPRKCSLCH QPGHTRTFCP QNR

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O70157-1-unknown	MIFPVT...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O70157-26-unknown	MEVAFR...	26	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000113057
O70157-26-unknown	MEVAFR...	26	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000113653
O70157-26-unknown	MEVAFR...	26	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000115727

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...FIDIKK	130	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSMUSP00000115727
	...CPQNR	1003	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)