TopFIND 4.0

O70276: Retinoid isomerohydrolase

General Information

Protein names
- Retinoid isomerohydrolase
- 3.1.1.64 {ECO:0000250|UniProtKB:Q28175}
- All-trans-retinyl-palmitate hydrolase
- Lutein isomerase
- Meso-zeaxanthin isomerase
- 5.3.3.22 {ECO:0000250|UniProtKB:Q16518}
- Retinal pigment epithelium-specific 65 kDa protein
- Retinol isomerase
Gene names Rpe65
Organism Rattus norvegicus
Protease Family
Protease ID
Chromosome location
UniProt ID O70276

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MSIQIEHPAG GYKKLFETVE ELSTPLTAHV TGRIPLWLTG SLLRCGPGLF EVGSEPFYHL 
        70         80         90        100        110        120 
FDGQALLHKF DFKEGHVTYY RRFIRTDAYV RAMTEKRIVI TEFGTCAFPD PCKNIFSRFF 
       130        140        150        160        170        180 
SYFRGVEITD NALVNIYPVG EDYYACTETN FITKINPETL ETIKQVDLCN YVSVNGATAH 
       190        200        210        220        230        240 
PHIESDGTVY NIGNCFGKNF TVAYNIIKIP PLKADKEDPI NKSEVVVQFP CSDRFKPSYV 
       250        260        270        280        290        300 
HSFGLTPNYI VFVETPVKIN LFKFLSSWSL WGANYMDCFE SNESMGVWLH VADKKRRKYF 
       310        320        330        340        350        360 
NNKYRTSPFN LFHHINTYED NGFLIVDLCC WKGFEFVYNY LYLANLRENW EEVKRNAMKA 
       370        380        390        400        410        420 
PQPEVRRYVL PLTIDKADTG RNLVTLPHTT ATAILCSDET IWLEPEVLFS GPRQAFEFPQ 
       430        440        450        460        470        480 
INYQKCGGKP YTYAYGLGLN HFVPDKLCKL NVKTKEIWMW QEPDSYPSEP IFVSQPDALE 
       490        500        510        520        530    
EDDGVVLSVV VSPGAGQKPA YLLVLNAKDL SEIARAEVET NIPVTFHGLF KKP

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    O70276-2-unknown MSIQIE... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    O70276-2-Acetylation SIQIEH... 2 acetylation- inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...LFKKP 533 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)