O75030: Microphthalmia-associated transcription factor

General Information

Protein names	- Microphthalmia-associated transcription factor - Class E basic helix-loop-helix protein 32 - bHLHe32
Gene names	MITF
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75030

2 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform A2 of Microphthalmia-associated transcription factor - Isoform B1 of Microphthalmia-associated transcription factor - Isoform B2 of Microphthalmia-associated transcription factor - Isoform C1 of Microphthalmia-associated transcription factor - Isoform C2 of Microphthalmia-associated transcription factor - Isoform H1 of Microphthalmia-associated transcription factor - Isoform H2 of Microphthalmia-associated transcription factor - Isoform M1 of Microphthalmia-associated transcription factor - Isoform M2 of Microphthalmia-associated transcription factor - Isoform Mdel of Microphthalmia-associated transcription factor - Isoform 12 of Microphthalmia-associated transcription factor

Sequence View

        10         20         30         40         50         60
MQSESGIVPD FEVGEEFHEE PKTYYELKSQ PLKSSSSAEH PGASKPPISS SSMTSRILLR
        70         80         90        100        110        120
QQLMREQMQE QERREQQQKL QAAQFMQQRV PVSQTPAINV SVPTTLPSAT QVPMEVLKVQ
       130        140        150        160        170        180
THLENPTKYH IQQAQRQQVK QYLSTTLANK HANQVLSLPC PNQPGDHVMP PVPGSSAPNS
       190        200        210        220        230        240
PMAMLTLNSN CEKEGFYKFE EQNRAESECP GMNTHSRASC MQMDDVIDDI ISLESSYNEE
       250        260        270        280        290        300
ILGLMDPALQ MANTLPVSGN LIDLYGNQGL PPPGLTISNS CPANLPNIKR ELTACIFPTE
       310        320        330        340        350        360
SEARALAKER QKKDNHNLIE RRRRFNINDR IKELGTLIPK SNDPDMRWNK GTILKASVDY
       370        380        390        400        410        420
IRKLQREQQR AKELENRQKK LEHANRHLLL RIQELEMQAR AHGLSLIPST GLCSPDLVNR
       430        440        450        460        470        480
IIKQEPVLEN CSQDLLQHHA DLTCTTTLDL TDGTITFNNN LGTGTEANQA YSVPTKMGSK
       490        500        510        520
LEDILMDDTL SPVGVTDPLL SSVSPGASKT SSRRSSMSME ETEHTC         10         20         30         40         50         60
MQSESGIVPD FEVGEEFHEE PKTYYELKSQ PLKSSSSAEH PGASKPPISS SSMTSRILLR
        70         80         90        100        110        120
QQLMREQMQE QERREQQQKL QAAQFMQQRV PVSQTPAINV SVPTTLPSAT QVPMEVLKVQ
       130        140        150        160        170        180
THLENPTKYH IQQAQRQQVK QYLSTTLANK HANQVLSLPC PNQPGDHVMP PVPGSSAPNS
       190        200        210        220        230        240
PMAMLTLNSN CEKEGFYKFE EQNRAESECP GMNTHSRASC MQMDDVIDDI ISLESSYNEE
       250        260        270        280        290        300
ILGLMDPALQ MANTLPVSGN LIDLYGNQGL PPPGLTISNS CPANLPNIKR ELTACIFPTE
       310        320        330        340        350        360
SEARALAKER QKKDNHNLIE RRRRFNINDR IKELGTLIPK SNDPDMRWNK GTILKASVDY
       370        380        390        400        410        420
IRKLQREQQR AKELENRQKK LEHANRHLLL RIQELEMQAR AHGLSLIPST GLCSPDLVNR
       430        440        450        460        470        480
IIKQEPVLEN CSQDLLQHHA DLTCTTTLDL TDGTITFNNN LGTGTEANQA YSVPTKMGSK
       490        500        510        520
LEDILMDDTL SPVGVTDPLL SSVSPGASKT SSRRSSMSME ETEHTC         10         20         30         40         50         60
MQSESGIVPD FEVGEEFHEE PKTYYELKSQ PLKSSSSAEH PGASKPPISS SSMTSRILLR
        70         80         90        100        110        120
QQLMREQMQE QERREQQQKL QAAQFMQQRV PVSQTPAINV SVPTTLPSAT QVPMEVLKVQ
       130        140        150        160        170        180
THLENPTKYH IQQAQRQQVK QYLSTTLANK HANQVLSLPC PNQPGDHVMP PVPGSSAPNS
       190        200        210        220        230        240
PMAMLTLNSN CEKEGFYKFE EQNRAESECP GMNTHSRASC MQMDDVIDDI ISLESSYNEE
       250        260        270        280        290        300
ILGLMDPALQ MANTLPVSGN LIDLYGNQGL PPPGLTISNS CPANLPNIKR ELTACIFPTE
       310        320        330        340        350        360
SEARALAKER QKKDNHNLIE RRRRFNINDR IKELGTLIPK SNDPDMRWNK GTILKASVDY
       370        380        390        400        410        420
IRKLQREQQR AKELENRQKK LEHANRHLLL RIQELEMQAR AHGLSLIPST GLCSPDLVNR
       430        440        450        460        470        480
IIKQEPVLEN CSQDLLQHHA DLTCTTTLDL TDGTITFNNN LGTGTEANQA YSVPTKMGSK
       490        500        510        520
LEDILMDDTL SPVGVTDPLL SSVSPGASKT SSRRSSMSME ETEHTC         10         20         30         40         50         60
MQSESGIVPD FEVGEEFHEE PKTYYELKSQ PLKSSSSAEH PGASKPPISS SSMTSRILLR
        70         80         90        100        110        120
QQLMREQMQE QERREQQQKL QAAQFMQQRV PVSQTPAINV SVPTTLPSAT QVPMEVLKVQ
       130        140        150        160        170        180
THLENPTKYH IQQAQRQQVK QYLSTTLANK HANQVLSLPC PNQPGDHVMP PVPGSSAPNS
       190        200        210        220        230        240
PMAMLTLNSN CEKEGFYKFE EQNRAESECP GMNTHSRASC MQMDDVIDDI ISLESSYNEE
       250        260        270        280        290        300
ILGLMDPALQ MANTLPVSGN LIDLYGNQGL PPPGLTISNS CPANLPNIKR ELTACIFPTE
       310        320        330        340        350        360
SEARALAKER QKKDNHNLIE RRRRFNINDR IKELGTLIPK SNDPDMRWNK GTILKASVDY
       370        380        390        400        410        420
IRKLQREQQR AKELENRQKK LEHANRHLLL RIQELEMQAR AHGLSLIPST GLCSPDLVNR
       430        440        450        460        470        480
IIKQEPVLEN CSQDLLQHHA DLTCTTTLDL TDGTITFNNN LGTGTEANQA YSVPTKMGSK
       490        500        510        520
LEDILMDDTL SPVGVTDPLL SSVSPGASKT SSRRSSMSME ETEHTC         10         20         30         40         50         60
MQSESGIVPD FEVGEEFHEE PKTYYELKSQ PLKSSSSAEH PGASKPPISS SSMTSRILLR
        70         80         90        100        110        120
QQLMREQMQE QERREQQQKL QAAQFMQQRV PVSQTPAINV SVPTTLPSAT QVPMEVLKVQ
       130        140        150        160        170        180
THLENPTKYH IQQAQRQQVK QYLSTTLANK HANQVLSLPC PNQPGDHVMP PVPGSSAPNS
       190        200        210        220        230        240
PMAMLTLNSN CEKEGFYKFE EQNRAESECP GMNTHSRASC MQMDDVIDDI ISLESSYNEE
       250        260        270        280        290        300
ILGLMDPALQ MANTLPVSGN LIDLYGNQGL PPPGLTISNS CPANLPNIKR ELTACIFPTE
       310        320        330        340        350        360
SEARALAKER QKKDNHNLIE RRRRFNINDR IKELGTLIPK SNDPDMRWNK GTILKASVDY
       370        380        390        400        410        420
IRKLQREQQR AKELENRQKK LEHANRHLLL RIQELEMQAR AHGLSLIPST GLCSPDLVNR
       430        440        450        460        470        480
IIKQEPVLEN CSQDLLQHHA DLTCTTTLDL TDGTITFNNN LGTGTEANQA YSVPTKMGSK
       490        500        510        520
LEDILMDDTL SPVGVTDPLL SSVSPGASKT SSRRSSMSME ETEHTC         10         20         30         40         50         60
MQSESGIVPD FEVGEEFHEE PKTYYELKSQ PLKSSSSAEH PGASKPPISS SSMTSRILLR
        70         80         90        100        110        120
QQLMREQMQE QERREQQQKL QAAQFMQQRV PVSQTPAINV SVPTTLPSAT QVPMEVLKVQ
       130        140        150        160        170        180
THLENPTKYH IQQAQRQQVK QYLSTTLANK HANQVLSLPC PNQPGDHVMP PVPGSSAPNS
       190        200        210        220        230        240
PMAMLTLNSN CEKEGFYKFE EQNRAESECP GMNTHSRASC MQMDDVIDDI ISLESSYNEE
       250        260        270        280        290        300
ILGLMDPALQ MANTLPVSGN LIDLYGNQGL PPPGLTISNS CPANLPNIKR ELTACIFPTE
       310        320        330        340        350        360
SEARALAKER QKKDNHNLIE RRRRFNINDR IKELGTLIPK SNDPDMRWNK GTILKASVDY
       370        380        390        400        410        420
IRKLQREQQR AKELENRQKK LEHANRHLLL RIQELEMQAR AHGLSLIPST GLCSPDLVNR
       430        440        450        460        470        480
IIKQEPVLEN CSQDLLQHHA DLTCTTTLDL TDGTITFNNN LGTGTEANQA YSVPTKMGSK
       490        500        510        520
LEDILMDDTL SPVGVTDPLL SSVSPGASKT SSRRSSMSME ETEHTC         10         20         30         40         50         60
MQSESGIVPD FEVGEEFHEE PKTYYELKSQ PLKSSSSAEH PGASKPPISS SSMTSRILLR
        70         80         90        100        110        120
QQLMREQMQE QERREQQQKL QAAQFMQQRV PVSQTPAINV SVPTTLPSAT QVPMEVLKVQ
       130        140        150        160        170        180
THLENPTKYH IQQAQRQQVK QYLSTTLANK HANQVLSLPC PNQPGDHVMP PVPGSSAPNS
       190        200        210        220        230        240
PMAMLTLNSN CEKEGFYKFE EQNRAESECP GMNTHSRASC MQMDDVIDDI ISLESSYNEE
       250        260        270        280        290        300
ILGLMDPALQ MANTLPVSGN LIDLYGNQGL PPPGLTISNS CPANLPNIKR ELTACIFPTE
       310        320        330        340        350        360
SEARALAKER QKKDNHNLIE RRRRFNINDR IKELGTLIPK SNDPDMRWNK GTILKASVDY
       370        380        390        400        410        420
IRKLQREQQR AKELENRQKK LEHANRHLLL RIQELEMQAR AHGLSLIPST GLCSPDLVNR
       430        440        450        460        470        480
IIKQEPVLEN CSQDLLQHHA DLTCTTTLDL TDGTITFNNN LGTGTEANQA YSVPTKMGSK
       490        500        510        520
LEDILMDDTL SPVGVTDPLL SSVSPGASKT SSRRSSMSME ETEHTC         10         20         30         40         50         60
MQSESGIVPD FEVGEEFHEE PKTYYELKSQ PLKSSSSAEH PGASKPPISS SSMTSRILLR
        70         80         90        100        110        120
QQLMREQMQE QERREQQQKL QAAQFMQQRV PVSQTPAINV SVPTTLPSAT QVPMEVLKVQ
       130        140        150        160        170        180
THLENPTKYH IQQAQRQQVK QYLSTTLANK HANQVLSLPC PNQPGDHVMP PVPGSSAPNS
       190        200        210        220        230        240
PMAMLTLNSN CEKEGFYKFE EQNRAESECP GMNTHSRASC MQMDDVIDDI ISLESSYNEE
       250        260        270        280        290        300
ILGLMDPALQ MANTLPVSGN LIDLYGNQGL PPPGLTISNS CPANLPNIKR ELTACIFPTE
       310        320        330        340        350        360
SEARALAKER QKKDNHNLIE RRRRFNINDR IKELGTLIPK SNDPDMRWNK GTILKASVDY
       370        380        390        400        410        420
IRKLQREQQR AKELENRQKK LEHANRHLLL RIQELEMQAR AHGLSLIPST GLCSPDLVNR
       430        440        450        460        470        480
IIKQEPVLEN CSQDLLQHHA DLTCTTTLDL TDGTITFNNN LGTGTEANQA YSVPTKMGSK
       490        500        510        520
LEDILMDDTL SPVGVTDPLL SSVSPGASKT SSRRSSMSME ETEHTC         10         20         30         40         50         60
MQSESGIVPD FEVGEEFHEE PKTYYELKSQ PLKSSSSAEH PGASKPPISS SSMTSRILLR
        70         80         90        100        110        120
QQLMREQMQE QERREQQQKL QAAQFMQQRV PVSQTPAINV SVPTTLPSAT QVPMEVLKVQ
       130        140        150        160        170        180
THLENPTKYH IQQAQRQQVK QYLSTTLANK HANQVLSLPC PNQPGDHVMP PVPGSSAPNS
       190        200        210        220        230        240
PMAMLTLNSN CEKEGFYKFE EQNRAESECP GMNTHSRASC MQMDDVIDDI ISLESSYNEE
       250        260        270        280        290        300
ILGLMDPALQ MANTLPVSGN LIDLYGNQGL PPPGLTISNS CPANLPNIKR ELTACIFPTE
       310        320        330        340        350        360
SEARALAKER QKKDNHNLIE RRRRFNINDR IKELGTLIPK SNDPDMRWNK GTILKASVDY
       370        380        390        400        410        420
IRKLQREQQR AKELENRQKK LEHANRHLLL RIQELEMQAR AHGLSLIPST GLCSPDLVNR
       430        440        450        460        470        480
IIKQEPVLEN CSQDLLQHHA DLTCTTTLDL TDGTITFNNN LGTGTEANQA YSVPTKMGSK
       490        500        510        520
LEDILMDDTL SPVGVTDPLL SSVSPGASKT SSRRSSMSME ETEHTC         10         20         30         40         50         60
MQSESGIVPD FEVGEEFHEE PKTYYELKSQ PLKSSSSAEH PGASKPPISS SSMTSRILLR
        70         80         90        100        110        120
QQLMREQMQE QERREQQQKL QAAQFMQQRV PVSQTPAINV SVPTTLPSAT QVPMEVLKVQ
       130        140        150        160        170        180
THLENPTKYH IQQAQRQQVK QYLSTTLANK HANQVLSLPC PNQPGDHVMP PVPGSSAPNS
       190        200        210        220        230        240
PMAMLTLNSN CEKEGFYKFE EQNRAESECP GMNTHSRASC MQMDDVIDDI ISLESSYNEE
       250        260        270        280        290        300
ILGLMDPALQ MANTLPVSGN LIDLYGNQGL PPPGLTISNS CPANLPNIKR ELTACIFPTE
       310        320        330        340        350        360
SEARALAKER QKKDNHNLIE RRRRFNINDR IKELGTLIPK SNDPDMRWNK GTILKASVDY
       370        380        390        400        410        420
IRKLQREQQR AKELENRQKK LEHANRHLLL RIQELEMQAR AHGLSLIPST GLCSPDLVNR
       430        440        450        460        470        480
IIKQEPVLEN CSQDLLQHHA DLTCTTTLDL TDGTITFNNN LGTGTEANQA YSVPTKMGSK
       490        500        510        520
LEDILMDDTL SPVGVTDPLL SSVSPGASKT SSRRSSMSME ETEHTC         10         20         30         40         50         60
MQSESGIVPD FEVGEEFHEE PKTYYELKSQ PLKSSSSAEH PGASKPPISS SSMTSRILLR
        70         80         90        100        110        120
QQLMREQMQE QERREQQQKL QAAQFMQQRV PVSQTPAINV SVPTTLPSAT QVPMEVLKVQ
       130        140        150        160        170        180
THLENPTKYH IQQAQRQQVK QYLSTTLANK HANQVLSLPC PNQPGDHVMP PVPGSSAPNS
       190        200        210        220        230        240
PMAMLTLNSN CEKEGFYKFE EQNRAESECP GMNTHSRASC MQMDDVIDDI ISLESSYNEE
       250        260        270        280        290        300
ILGLMDPALQ MANTLPVSGN LIDLYGNQGL PPPGLTISNS CPANLPNIKR ELTACIFPTE
       310        320        330        340        350        360
SEARALAKER QKKDNHNLIE RRRRFNINDR IKELGTLIPK SNDPDMRWNK GTILKASVDY
       370        380        390        400        410        420
IRKLQREQQR AKELENRQKK LEHANRHLLL RIQELEMQAR AHGLSLIPST GLCSPDLVNR
       430        440        450        460        470        480
IIKQEPVLEN CSQDLLQHHA DLTCTTTLDL TDGTITFNNN LGTGTEANQA YSVPTKMGSK
       490        500        510        520
LEDILMDDTL SPVGVTDPLL SSVSPGASKT SSRRSSMSME ETEHTC

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O75030-1-unknown	MQSESG...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O75030-1-unknown	MQSESG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81170
O75030-346-unknown	MRWNKG...	346	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1475
O75030-346-unknown	MRWNKG...	346	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148044
O75030-346-unknown	MRWNKG...	346	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150230
O75030-346-unknown	MRWNKG...	346	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150370
O75030-346-unknown	MRWNKG...	346	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150418
O75030-346-unknown	MRWNKG...	346	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150537
O75030-346-unknown	MRWNKG...	346	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150711
O75030-346-unknown	MRWNKG...	346	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150744
O75030-346-unknown	MRWNKG...	346	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150851

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SNDPDM	345	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1475
...SNDPDM	345	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131407
...SNDPDM	345	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133624
...SNDPDM	345	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133767
...SNDPDM	345	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133814
...SNDPDM	345	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133933
...SNDPDM	345	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134109
...SNDPDM	345	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134143
...SNDPDM	345	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134252
...TEHTC	526	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TEHTC	526	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76795
...TEHTC	526	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76790
...TEHTC	526	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76789
...TEHTC	526	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76794
...TEHTC	526	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76793
...TEHTC	526	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76792
...TEHTC	526	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76788
...TEHTC	526	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76791

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	345	DPDM.\|.MRWN	inferred from experiment	unknown	MEROPS	Bertolotto C	Larribere L et al.:The cleavage of microphthalmia-... (C14.003)	16140982,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)