TopFIND 4.0

O75298: Reticulon-2

General Information

Protein names
- Reticulon-2
- Neuroendocrine-specific protein-like 1
- NSP-like protein 1
- Neuroendocrine-specific protein-like I
- NSP-like protein I
- NSPLI
Gene names RTN2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID O75298

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MGQVLPVFAH CKEAPSTASS TPDSTEGGND DSDFRELHTA REFSEEDEEE TTSQDWGTPR 
        70         80         90        100        110        120 
ELTFSYIAFD GVVGSGGRRD STARRPRPQG RSVSEPRDQH PQPSLGDSLE SIPSLSQSPE 
       130        140        150        160        170        180 
PGRRGDPDTA PPSERPLEDL RLRLDHLGWV ARGTGSGEDS STSSSTPLED EEPQEPNRLE 
       190        200        210        220        230        240 
TGEAGEELDL RLRLAQPSSP EVLTPQLSPG SGTPQAGTPS PSRSRDSNSG PEEPLLEEEE 
       250        260        270        280        290        300 
KQWGPLEREP VRGQCLDSTD QLEFTVEPRL LGTAMEWLKT SLLLAVYKTV PILELSPPLW 
       310        320        330        340        350        360 
TAIGWVQRGP TPPTPVLRVL LKWAKSPRSS GVPSLSLGAD MGSKVADLLY WKDTRTSGVV 
       370        380        390        400        410        420 
FTGLMVSLLC LLHFSIVSVA AHLALLLLCG TISLRVYRKV LQAVHRGDGA NPFQAYLDVD 
       430        440        450        460        470        480 
LTLTREQTER LSHQITSRVV SAATQLRHFF LVEDLVDSLK LALLFYILTF VGAIFNGLTL 
       490        500        510        520        530        540 
LILGVIGLFT IPLLYRQHQA QIDQYVGLVT NQLSHIKAKI RAKIPGTGAL ASAAAAVSGS 
   
KAKAE

Isoforms

- Isoform RTN2-B of Reticulon-2 - Isoform RTN2-C of Reticulon-2

Sequence View

        10         20         30         40         50         60 
MGQVLPVFAH CKEAPSTASS TPDSTEGGND DSDFRELHTA REFSEEDEEE TTSQDWGTPR 
        70         80         90        100        110        120 
ELTFSYIAFD GVVGSGGRRD STARRPRPQG RSVSEPRDQH PQPSLGDSLE SIPSLSQSPE 
       130        140        150        160        170        180 
PGRRGDPDTA PPSERPLEDL RLRLDHLGWV ARGTGSGEDS STSSSTPLED EEPQEPNRLE 
       190        200        210        220        230        240 
TGEAGEELDL RLRLAQPSSP EVLTPQLSPG SGTPQAGTPS PSRSRDSNSG PEEPLLEEEE 
       250        260        270        280        290        300 
KQWGPLEREP VRGQCLDSTD QLEFTVEPRL LGTAMEWLKT SLLLAVYKTV PILELSPPLW 
       310        320        330        340        350        360 
TAIGWVQRGP TPPTPVLRVL LKWAKSPRSS GVPSLSLGAD MGSKVADLLY WKDTRTSGVV 
       370        380        390        400        410        420 
FTGLMVSLLC LLHFSIVSVA AHLALLLLCG TISLRVYRKV LQAVHRGDGA NPFQAYLDVD 
       430        440        450        460        470        480 
LTLTREQTER LSHQITSRVV SAATQLRHFF LVEDLVDSLK LALLFYILTF VGAIFNGLTL 
       490        500        510        520        530        540 
LILGVIGLFT IPLLYRQHQA QIDQYVGLVT NQLSHIKAKI RAKIPGTGAL ASAAAAVSGS 
   
KAKAE         10         20         30         40         50         60 
MGQVLPVFAH CKEAPSTASS TPDSTEGGND DSDFRELHTA REFSEEDEEE TTSQDWGTPR 
        70         80         90        100        110        120 
ELTFSYIAFD GVVGSGGRRD STARRPRPQG RSVSEPRDQH PQPSLGDSLE SIPSLSQSPE 
       130        140        150        160        170        180 
PGRRGDPDTA PPSERPLEDL RLRLDHLGWV ARGTGSGEDS STSSSTPLED EEPQEPNRLE 
       190        200        210        220        230        240 
TGEAGEELDL RLRLAQPSSP EVLTPQLSPG SGTPQAGTPS PSRSRDSNSG PEEPLLEEEE 
       250        260        270        280        290        300 
KQWGPLEREP VRGQCLDSTD QLEFTVEPRL LGTAMEWLKT SLLLAVYKTV PILELSPPLW 
       310        320        330        340        350        360 
TAIGWVQRGP TPPTPVLRVL LKWAKSPRSS GVPSLSLGAD MGSKVADLLY WKDTRTSGVV 
       370        380        390        400        410        420 
FTGLMVSLLC LLHFSIVSVA AHLALLLLCG TISLRVYRKV LQAVHRGDGA NPFQAYLDVD 
       430        440        450        460        470        480 
LTLTREQTER LSHQITSRVV SAATQLRHFF LVEDLVDSLK LALLFYILTF VGAIFNGLTL 
       490        500        510        520        530        540 
LILGVIGLFT IPLLYRQHQA QIDQYVGLVT NQLSHIKAKI RAKIPGTGAL ASAAAAVSGS 
   
KAKAE



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    O75298-1-unknown MGQVLP... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    O75298-1-unknown MGQVLP... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt88337
    O75298-341-unknown MGSKVA... 341 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt88338
    O75298-341-unknown MGSKVA... 341 inferred from electronic annotation unknown TISdb inferred from TISdb

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)