O75469: Nuclear receptor subfamily 1 group I member 2

General Information

Protein names	- Nuclear receptor subfamily 1 group I member 2 - Orphan nuclear receptor PAR1 - Orphan nuclear receptor PXR - Pregnane X receptor - Steroid and xenobiotic receptor - SXR
Gene names	NR1I2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75469

2 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 1B of Nuclear receptor subfamily 1 group I member 2 - Isoform 1C of Nuclear receptor subfamily 1 group I member 2 - Isoform 2A of Nuclear receptor subfamily 1 group I member 2 - Isoform 2B of Nuclear receptor subfamily 1 group I member 2 - Isoform 2C of Nuclear receptor subfamily 1 group I member 2 - Isoform 3 of Nuclear receptor subfamily 1 group I member 2

Sequence View

        10         20         30         40         50         60
MEVRPKESWN HADFVHCEDT ESVPGKPSVN ADEEVGGPQI CRVCGDKATG YHFNVMTCEG
        70         80         90        100        110        120
CKGFFRRAMK RNARLRCPFR KGACEITRKT RRQCQACRLR KCLESGMKKE MIMSDEAVEE
       130        140        150        160        170        180
RRALIKRKKS ERTGTQPLGV QGLTEEQRMM IRELMDAQMK TFDTTFSHFK NFRLPGVLSS
       190        200        210        220        230        240
GCELPESLQA PSREEAAKWS QVRKDLCSLK VSLQLRGEDG SVWNYKPPAD SGGKEIFSLL
       250        260        270        280        290        300
PHMADMSTYM FKGIISFAKV ISYFRDLPIE DQISLLKGAA FELCQLRFNT VFNAETGTWE
       310        320        330        340        350        360
CGRLSYCLED TAGGFQQLLL EPMLKFHYML KKLQLHEEEY VLMQAISLFS PDRPGVLQHR
       370        380        390        400        410        420
VVDQLQEQFA ITLKSYIECN RPQPAHRFLF LKIMAMLTEL RSINAQHTQR LLRIQDIHPF
       430
ATPLMQELFG ITGS         10         20         30         40         50         60
MEVRPKESWN HADFVHCEDT ESVPGKPSVN ADEEVGGPQI CRVCGDKATG YHFNVMTCEG
        70         80         90        100        110        120
CKGFFRRAMK RNARLRCPFR KGACEITRKT RRQCQACRLR KCLESGMKKE MIMSDEAVEE
       130        140        150        160        170        180
RRALIKRKKS ERTGTQPLGV QGLTEEQRMM IRELMDAQMK TFDTTFSHFK NFRLPGVLSS
       190        200        210        220        230        240
GCELPESLQA PSREEAAKWS QVRKDLCSLK VSLQLRGEDG SVWNYKPPAD SGGKEIFSLL
       250        260        270        280        290        300
PHMADMSTYM FKGIISFAKV ISYFRDLPIE DQISLLKGAA FELCQLRFNT VFNAETGTWE
       310        320        330        340        350        360
CGRLSYCLED TAGGFQQLLL EPMLKFHYML KKLQLHEEEY VLMQAISLFS PDRPGVLQHR
       370        380        390        400        410        420
VVDQLQEQFA ITLKSYIECN RPQPAHRFLF LKIMAMLTEL RSINAQHTQR LLRIQDIHPF
       430
ATPLMQELFG ITGS         10         20         30         40         50         60
MEVRPKESWN HADFVHCEDT ESVPGKPSVN ADEEVGGPQI CRVCGDKATG YHFNVMTCEG
        70         80         90        100        110        120
CKGFFRRAMK RNARLRCPFR KGACEITRKT RRQCQACRLR KCLESGMKKE MIMSDEAVEE
       130        140        150        160        170        180
RRALIKRKKS ERTGTQPLGV QGLTEEQRMM IRELMDAQMK TFDTTFSHFK NFRLPGVLSS
       190        200        210        220        230        240
GCELPESLQA PSREEAAKWS QVRKDLCSLK VSLQLRGEDG SVWNYKPPAD SGGKEIFSLL
       250        260        270        280        290        300
PHMADMSTYM FKGIISFAKV ISYFRDLPIE DQISLLKGAA FELCQLRFNT VFNAETGTWE
       310        320        330        340        350        360
CGRLSYCLED TAGGFQQLLL EPMLKFHYML KKLQLHEEEY VLMQAISLFS PDRPGVLQHR
       370        380        390        400        410        420
VVDQLQEQFA ITLKSYIECN RPQPAHRFLF LKIMAMLTEL RSINAQHTQR LLRIQDIHPF
       430
ATPLMQELFG ITGS         10         20         30         40         50         60
MEVRPKESWN HADFVHCEDT ESVPGKPSVN ADEEVGGPQI CRVCGDKATG YHFNVMTCEG
        70         80         90        100        110        120
CKGFFRRAMK RNARLRCPFR KGACEITRKT RRQCQACRLR KCLESGMKKE MIMSDEAVEE
       130        140        150        160        170        180
RRALIKRKKS ERTGTQPLGV QGLTEEQRMM IRELMDAQMK TFDTTFSHFK NFRLPGVLSS
       190        200        210        220        230        240
GCELPESLQA PSREEAAKWS QVRKDLCSLK VSLQLRGEDG SVWNYKPPAD SGGKEIFSLL
       250        260        270        280        290        300
PHMADMSTYM FKGIISFAKV ISYFRDLPIE DQISLLKGAA FELCQLRFNT VFNAETGTWE
       310        320        330        340        350        360
CGRLSYCLED TAGGFQQLLL EPMLKFHYML KKLQLHEEEY VLMQAISLFS PDRPGVLQHR
       370        380        390        400        410        420
VVDQLQEQFA ITLKSYIECN RPQPAHRFLF LKIMAMLTEL RSINAQHTQR LLRIQDIHPF
       430
ATPLMQELFG ITGS         10         20         30         40         50         60
MEVRPKESWN HADFVHCEDT ESVPGKPSVN ADEEVGGPQI CRVCGDKATG YHFNVMTCEG
        70         80         90        100        110        120
CKGFFRRAMK RNARLRCPFR KGACEITRKT RRQCQACRLR KCLESGMKKE MIMSDEAVEE
       130        140        150        160        170        180
RRALIKRKKS ERTGTQPLGV QGLTEEQRMM IRELMDAQMK TFDTTFSHFK NFRLPGVLSS
       190        200        210        220        230        240
GCELPESLQA PSREEAAKWS QVRKDLCSLK VSLQLRGEDG SVWNYKPPAD SGGKEIFSLL
       250        260        270        280        290        300
PHMADMSTYM FKGIISFAKV ISYFRDLPIE DQISLLKGAA FELCQLRFNT VFNAETGTWE
       310        320        330        340        350        360
CGRLSYCLED TAGGFQQLLL EPMLKFHYML KKLQLHEEEY VLMQAISLFS PDRPGVLQHR
       370        380        390        400        410        420
VVDQLQEQFA ITLKSYIECN RPQPAHRFLF LKIMAMLTEL RSINAQHTQR LLRIQDIHPF
       430
ATPLMQELFG ITGS         10         20         30         40         50         60
MEVRPKESWN HADFVHCEDT ESVPGKPSVN ADEEVGGPQI CRVCGDKATG YHFNVMTCEG
        70         80         90        100        110        120
CKGFFRRAMK RNARLRCPFR KGACEITRKT RRQCQACRLR KCLESGMKKE MIMSDEAVEE
       130        140        150        160        170        180
RRALIKRKKS ERTGTQPLGV QGLTEEQRMM IRELMDAQMK TFDTTFSHFK NFRLPGVLSS
       190        200        210        220        230        240
GCELPESLQA PSREEAAKWS QVRKDLCSLK VSLQLRGEDG SVWNYKPPAD SGGKEIFSLL
       250        260        270        280        290        300
PHMADMSTYM FKGIISFAKV ISYFRDLPIE DQISLLKGAA FELCQLRFNT VFNAETGTWE
       310        320        330        340        350        360
CGRLSYCLED TAGGFQQLLL EPMLKFHYML KKLQLHEEEY VLMQAISLFS PDRPGVLQHR
       370        380        390        400        410        420
VVDQLQEQFA ITLKSYIECN RPQPAHRFLF LKIMAMLTEL RSINAQHTQR LLRIQDIHPF
       430
ATPLMQELFG ITGS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O75469-1-unknown	MEVRPK...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O75469-1-unknown	MEVRPK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83189
O75469-56-unknown	MTCEGC...	56	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83187
O75469-56-unknown	MTCEGC...	56	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83190
O75469-56-unknown	MTCEGC...	56	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109394
O75469-56-unknown	MTCEGC...	56	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109393
O75469-56-unknown	MTCEGC...	56	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109395
O75469-56-unknown	MTCEGC...	56	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt109392

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GITGS	434	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GITGS	434	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78808
...GITGS	434	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78805
...GITGS	434	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78807
...GITGS	434	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78809
...GITGS	434	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78806
...GITGS	434	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78810

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)