O75914: Serine/threonine-protein kinase PAK 3

General Information

Protein names	- Serine/threonine-protein kinase PAK 3 - 2.7.11.1 - Beta-PAK - Oligophrenin-3 - p21-activated kinase 3 - PAK-3
Gene names	PAK3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75914

2 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Serine/threonine-protein kinase PAK 3 - Isoform 3 of Serine/threonine-protein kinase PAK 3 - Isoform 4 of Serine/threonine-protein kinase PAK 3

Sequence View

        10         20         30         40         50         60
MSDGLDNEEK PPAPPLRMNS NNRDSSALNH SSKPLPMAPE EKNKKARLRS IFPGGGDKTN
        70         80         90        100        110        120
KKKEKERPEI SLPSDFEHTI HVGFDAVTGE FTPDLYGSQM CPGKLPEGIP EQWARLLQTS
       130        140        150        160        170        180
NITKLEQKKN PQAVLDVLKF YDSKETVNNQ KYMSFTSGDK SAHGYIAAHP SSTKTASEPP
       190        200        210        220        230        240
LAPPVSEEED EEEEEEEDEN EPPPVIAPRP EHTKSIYTRS VVESIASPAV PNKEVTPPSA
       250        260        270        280        290        300
ENANSSTLYR NTDRQRKKSK MTDEEILEKL RSIVSVGDPK KKYTRFEKIG QGASGTVYTA
       310        320        330        340        350        360
LDIATGQEVA IKQMNLQQQP KKELIINEIL VMRENKNPNI VNYLDSYLVG DELWVVMEYL
       370        380        390        400        410        420
AGGSLTDVVT ETCMDEGQIA AVCRECLQAL DFLHSNQVIH RDIKSDNILL GMDGSVKLTD
       430        440        450        460        470        480
FGFCAQITPE QSKRSTMVGT PYWMAPEVVT RKAYGPKVDI WSLGIMAIEM VEGEPPYLNE
       490        500        510        520        530        540
NPLRALYLIA TNGTPELQNP ERLSAVFRDF LNRCLEMDVD RRGSAKELLQ HPFLKLAKPL
       550
SSLTPLIIAA KEAIKNSSR         10         20         30         40         50         60
MSDGLDNEEK PPAPPLRMNS NNRDSSALNH SSKPLPMAPE EKNKKARLRS IFPGGGDKTN
        70         80         90        100        110        120
KKKEKERPEI SLPSDFEHTI HVGFDAVTGE FTPDLYGSQM CPGKLPEGIP EQWARLLQTS
       130        140        150        160        170        180
NITKLEQKKN PQAVLDVLKF YDSKETVNNQ KYMSFTSGDK SAHGYIAAHP SSTKTASEPP
       190        200        210        220        230        240
LAPPVSEEED EEEEEEEDEN EPPPVIAPRP EHTKSIYTRS VVESIASPAV PNKEVTPPSA
       250        260        270        280        290        300
ENANSSTLYR NTDRQRKKSK MTDEEILEKL RSIVSVGDPK KKYTRFEKIG QGASGTVYTA
       310        320        330        340        350        360
LDIATGQEVA IKQMNLQQQP KKELIINEIL VMRENKNPNI VNYLDSYLVG DELWVVMEYL
       370        380        390        400        410        420
AGGSLTDVVT ETCMDEGQIA AVCRECLQAL DFLHSNQVIH RDIKSDNILL GMDGSVKLTD
       430        440        450        460        470        480
FGFCAQITPE QSKRSTMVGT PYWMAPEVVT RKAYGPKVDI WSLGIMAIEM VEGEPPYLNE
       490        500        510        520        530        540
NPLRALYLIA TNGTPELQNP ERLSAVFRDF LNRCLEMDVD RRGSAKELLQ HPFLKLAKPL
       550
SSLTPLIIAA KEAIKNSSR         10         20         30         40         50         60
MSDGLDNEEK PPAPPLRMNS NNRDSSALNH SSKPLPMAPE EKNKKARLRS IFPGGGDKTN
        70         80         90        100        110        120
KKKEKERPEI SLPSDFEHTI HVGFDAVTGE FTPDLYGSQM CPGKLPEGIP EQWARLLQTS
       130        140        150        160        170        180
NITKLEQKKN PQAVLDVLKF YDSKETVNNQ KYMSFTSGDK SAHGYIAAHP SSTKTASEPP
       190        200        210        220        230        240
LAPPVSEEED EEEEEEEDEN EPPPVIAPRP EHTKSIYTRS VVESIASPAV PNKEVTPPSA
       250        260        270        280        290        300
ENANSSTLYR NTDRQRKKSK MTDEEILEKL RSIVSVGDPK KKYTRFEKIG QGASGTVYTA
       310        320        330        340        350        360
LDIATGQEVA IKQMNLQQQP KKELIINEIL VMRENKNPNI VNYLDSYLVG DELWVVMEYL
       370        380        390        400        410        420
AGGSLTDVVT ETCMDEGQIA AVCRECLQAL DFLHSNQVIH RDIKSDNILL GMDGSVKLTD
       430        440        450        460        470        480
FGFCAQITPE QSKRSTMVGT PYWMAPEVVT RKAYGPKVDI WSLGIMAIEM VEGEPPYLNE
       490        500        510        520        530        540
NPLRALYLIA TNGTPELQNP ERLSAVFRDF LNRCLEMDVD RRGSAKELLQ HPFLKLAKPL
       550
SSLTPLIIAA KEAIKNSSR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O75914-1-unknown	MSDGLD...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75914-1-unknown	MSDGLD...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84174
O75914-1-unknown	MSDGLD...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84175
O75914-1-unknown	MSDGLD...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84176
O75914-2-acetylation	SDGLDN...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O75914-2-acetylation	SDGLDN...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt179016
O75914-2-acetylation	SDGLDN...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt179017
O75914-2-acetylation	SDGLDN...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt179018

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KNSSR	559	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KNSSR	559	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79792
...KNSSR	559	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79794
...KNSSR	559	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79793

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)