TopFIND 4.0

O75928: E3 SUMO-protein ligase PIAS2

General Information

Protein names
- E3 SUMO-protein ligase PIAS2
- 2.3.2.-
- Androgen receptor-interacting protein 3
- ARIP3
- DAB2-interacting protein
- DIP
- E3 SUMO-protein transferase PIAS2 {ECO:0000305}
- Msx-interacting zinc finger protein
- Miz1
- PIAS-NY protein
- Protein inhibitor of activated STAT x
- Protein inhibitor of activated STAT2
Gene names PIAS2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID O75928

1

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MADFEELRNM VSSFRVSELQ VLLGFAGRNK SGRKHDLLMR ALHLLKSGCS PAVQIKIREL 
        70         80         90        100        110        120 
YRRRYPRTLE GLSDLSTIKS SVFSLDGGSS PVEPDLAVAG IHSLPSTSVT PHSPSSPVGS 
       130        140        150        160        170        180 
VLLQDTKPTF EMQQPSPPIP PVHPDVQLKN LPFYDVLDVL IKPTSLVQSS IQRFQEKFFI 
       190        200        210        220        230        240 
FALTPQQVRE ICISRDFLPG GRRDYTVQVQ LRLCLAETSC PQEDNYPNSL CIKVNGKLFP 
       250        260        270        280        290        300 
LPGYAPPPKN GIEQKRPGRP LNITSLVRLS SAVPNQISIS WASEIGKNYS MSVYLVRQLT 
       310        320        330        340        350        360 
SAMLLQRLKM KGIRNPDHSR ALIKEKLTAD PDSEIATTSL RVSLMCPLGK MRLTIPCRAV 
       370        380        390        400        410        420 
TCTHLQCFDA ALYLQMNEKK PTWICPVCDK KAAYESLILD GLFMEILNDC SDVDEIKFQE 
       430        440        450        460        470        480 
DGSWCPMRPK KEAMKVSSQP CTKIESSSVL SKPCSVTVAS EASKKKVDVI DLTIESSSDE 
       490        500        510        520        530        540 
EEDPPAKRKC IFMSETQSSP TKGVLMYQPS SVRVPSVTSV DPAAIPPSLT DYSVPFHHTP 
       550        560        570        580        590        600 
ISSMSSDLPG LDFLSLIPVD PQYCPPMFLD SLTSPLTASS TSVTTTSSHE SSTHVSSSSS 
       610        620    
RSETGVITSS GSNIPDIISL D

Isoforms

- Isoform PIAS2-alpha of E3 SUMO-protein ligase PIAS2 - Isoform 3 of E3 SUMO-protein ligase PIAS2

Sequence View

        10         20         30         40         50         60 
MADFEELRNM VSSFRVSELQ VLLGFAGRNK SGRKHDLLMR ALHLLKSGCS PAVQIKIREL 
        70         80         90        100        110        120 
YRRRYPRTLE GLSDLSTIKS SVFSLDGGSS PVEPDLAVAG IHSLPSTSVT PHSPSSPVGS 
       130        140        150        160        170        180 
VLLQDTKPTF EMQQPSPPIP PVHPDVQLKN LPFYDVLDVL IKPTSLVQSS IQRFQEKFFI 
       190        200        210        220        230        240 
FALTPQQVRE ICISRDFLPG GRRDYTVQVQ LRLCLAETSC PQEDNYPNSL CIKVNGKLFP 
       250        260        270        280        290        300 
LPGYAPPPKN GIEQKRPGRP LNITSLVRLS SAVPNQISIS WASEIGKNYS MSVYLVRQLT 
       310        320        330        340        350        360 
SAMLLQRLKM KGIRNPDHSR ALIKEKLTAD PDSEIATTSL RVSLMCPLGK MRLTIPCRAV 
       370        380        390        400        410        420 
TCTHLQCFDA ALYLQMNEKK PTWICPVCDK KAAYESLILD GLFMEILNDC SDVDEIKFQE 
       430        440        450        460        470        480 
DGSWCPMRPK KEAMKVSSQP CTKIESSSVL SKPCSVTVAS EASKKKVDVI DLTIESSSDE 
       490        500        510        520        530        540 
EEDPPAKRKC IFMSETQSSP TKGVLMYQPS SVRVPSVTSV DPAAIPPSLT DYSVPFHHTP 
       550        560        570        580        590        600 
ISSMSSDLPG LDFLSLIPVD PQYCPPMFLD SLTSPLTASS TSVTTTSSHE SSTHVSSSSS 
       610        620    
RSETGVITSS GSNIPDIISL D         10         20         30         40         50         60 
MADFEELRNM VSSFRVSELQ VLLGFAGRNK SGRKHDLLMR ALHLLKSGCS PAVQIKIREL 
        70         80         90        100        110        120 
YRRRYPRTLE GLSDLSTIKS SVFSLDGGSS PVEPDLAVAG IHSLPSTSVT PHSPSSPVGS 
       130        140        150        160        170        180 
VLLQDTKPTF EMQQPSPPIP PVHPDVQLKN LPFYDVLDVL IKPTSLVQSS IQRFQEKFFI 
       190        200        210        220        230        240 
FALTPQQVRE ICISRDFLPG GRRDYTVQVQ LRLCLAETSC PQEDNYPNSL CIKVNGKLFP 
       250        260        270        280        290        300 
LPGYAPPPKN GIEQKRPGRP LNITSLVRLS SAVPNQISIS WASEIGKNYS MSVYLVRQLT 
       310        320        330        340        350        360 
SAMLLQRLKM KGIRNPDHSR ALIKEKLTAD PDSEIATTSL RVSLMCPLGK MRLTIPCRAV 
       370        380        390        400        410        420 
TCTHLQCFDA ALYLQMNEKK PTWICPVCDK KAAYESLILD GLFMEILNDC SDVDEIKFQE 
       430        440        450        460        470        480 
DGSWCPMRPK KEAMKVSSQP CTKIESSSVL SKPCSVTVAS EASKKKVDVI DLTIESSSDE 
       490        500        510        520        530        540 
EEDPPAKRKC IFMSETQSSP TKGVLMYQPS SVRVPSVTSV DPAAIPPSLT DYSVPFHHTP 
       550        560        570        580        590        600 
ISSMSSDLPG LDFLSLIPVD PQYCPPMFLD SLTSPLTASS TSVTTTSSHE SSTHVSSSSS 
       610        620    
RSETGVITSS GSNIPDIISL D



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    O75928-1-unknown MADFEE... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    O75928-1-unknown MADFEE... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt85154

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)