TopFIND 4.0

O76062: Delta(14)-sterol reductase

General Information

Protein names
- Delta(14)-sterol reductase
- Delta-14-SR
- 1.3.1.70 {ECO:0000250|UniProtKB:Q8WMV1}
- 3-beta-hydroxysterol Delta (14)-reductase {ECO:0000303|PubMed:16784888}
- Another new gene 1 protein
- C-14 sterol reductase
- C14SR {ECO:0000303|PubMed:16784888}
- Putative sterol reductase SR-1
- Sterol C14-reductase
- Transmembrane 7 superfamily member 2
Gene names TM7SF2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID O76062

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAPTQGPRAP LEFGGPLGAA ALLLLLPATM FHLLLAARSG PARLLGPPAS LPGLEVLWSP 
        70         80         90        100        110        120 
RALLLWLAWL GLQAALYLLP ARKVAEGQEL KDKSRLRYPI NGFQALVLTA LLVGLGMSAG 
       130        140        150        160        170        180 
LPLGALPEML LPLAFVATLT AFIFSLFLYM KAQVAPVSAL APGGNSGNPI YDFFLGRELN 
       190        200        210        220        230        240 
PRICFFDFKY FCELRPGLIG WVLINLALLM KEAELRGSPS LAMWLVNGFQ LLYVGDALWH 
       250        260        270        280        290        300 
EEAVLTTMDI THDGFGFMLA FGDMAWVPFT YSLQAQFLLH HPQPLGLPMA SVICLINATG 
       310        320        330        340        350        360 
YYIFRGANSQ KNTFRKNPSD PRVAGLETIS TATGRKLLVS GWWGMVRHPN YLGDLIMALA 
       370        380        390        400        410    
WSLPCGVSHL LPYFYLLYFT ALLVHREARD ERQCLQKYGL AWQEYCRRVP YRIMPYIY

Isoforms

- Isoform 2 of Delta(14)-sterol reductase - Isoform 2 of Delta(14)-sterol reductase TM7SF2

Sequence View

        10         20         30         40         50         60 
MAPTQGPRAP LEFGGPLGAA ALLLLLPATM FHLLLAARSG PARLLGPPAS LPGLEVLWSP 
        70         80         90        100        110        120 
RALLLWLAWL GLQAALYLLP ARKVAEGQEL KDKSRLRYPI NGFQALVLTA LLVGLGMSAG 
       130        140        150        160        170        180 
LPLGALPEML LPLAFVATLT AFIFSLFLYM KAQVAPVSAL APGGNSGNPI YDFFLGRELN 
       190        200        210        220        230        240 
PRICFFDFKY FCELRPGLIG WVLINLALLM KEAELRGSPS LAMWLVNGFQ LLYVGDALWH 
       250        260        270        280        290        300 
EEAVLTTMDI THDGFGFMLA FGDMAWVPFT YSLQAQFLLH HPQPLGLPMA SVICLINATG 
       310        320        330        340        350        360 
YYIFRGANSQ KNTFRKNPSD PRVAGLETIS TATGRKLLVS GWWGMVRHPN YLGDLIMALA 
       370        380        390        400        410    
WSLPCGVSHL LPYFYLLYFT ALLVHREARD ERQCLQKYGL AWQEYCRRVP YRIMPYIY         10         20         30         40         50         60 
MAPTQGPRAP LEFGGPLGAA ALLLLLPATM FHLLLAARSG PARLLGPPAS LPGLEVLWSP 
        70         80         90        100        110        120 
RALLLWLAWL GLQAALYLLP ARKVAEGQEL KDKSRLRYPI NGFQALVLTA LLVGLGMSAG 
       130        140        150        160        170        180 
LPLGALPEML LPLAFVATLT AFIFSLFLYM KAQVAPVSAL APGGNSGNPI YDFFLGRELN 
       190        200        210        220        230        240 
PRICFFDFKY FCELRPGLIG WVLINLALLM KEAELRGSPS LAMWLVNGFQ LLYVGDALWH 
       250        260        270        280        290        300 
EEAVLTTMDI THDGFGFMLA FGDMAWVPFT YSLQAQFLLH HPQPLGLPMA SVICLINATG 
       310        320        330        340        350        360 
YYIFRGANSQ KNTFRKNPSD PRVAGLETIS TATGRKLLVS GWWGMVRHPN YLGDLIMALA 
       370        380        390        400        410    
WSLPCGVSHL LPYFYLLYFT ALLVHREARD ERQCLQKYGL AWQEYCRRVP YRIMPYIY



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


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Protease Assignment Confidence:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    O76062-1-unknown MAPTQG... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    O76062-1-unknown MAPTQG... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt74125

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...MPYIY 418 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...MPYIY 418 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt69743

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)