TopFIND 4.0

O76090: Bestrophin-1

General Information

Protein names
- Bestrophin-1
- TU15B
- Vitelliform macular dystrophy protein 2
Gene names BEST1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID O76090

4

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MTITYTSQVA NARLGSFSRL LLCWRGSIYK LLYGEFLIFL LCYYIIRFIY RLALTEEQQL 
        70         80         90        100        110        120 
MFEKLTLYCD SYIQLIPISF VLGFYVTLVV TRWWNQYENL PWPDRLMSLV SGFVEGKDEQ 
       130        140        150        160        170        180 
GRLLRRTLIR YANLGNVLIL RSVSTAVYKR FPSAQHLVQA GFMTPAEHKQ LEKLSLPHNM 
       190        200        210        220        230        240 
FWVPWVWFAN LSMKAWLGGR IRDPILLQSL LNEMNTLRTQ CGHLYAYDWI SIPLVYTQVV 
       250        260        270        280        290        300 
TVAVYSFFLT CLVGRQFLNP AKAYPGHELD LVVPVFTFLQ FFFYVGWLKV AEQLINPFGE 
       310        320        330        340        350        360 
DDDDFETNWI VDRNLQVSLL AVDEMHQDLP RMEPDMYWNK PEPQPPYTAA SAQFRRASFM 
       370        380        390        400        410        420 
GSTFNISLNK EEMEFQPNQE DEEDAHAGII GRFLGLQSHD HHPPRANSRT KLLWPKRESL 
       430        440        450        460        470        480 
LHEGLPKNHK AAKQNVRGQE DNKAWKLKAV DAFKSAPLYQ RPGYYSAPQT PLSPTPMFFP 
       490        500        510        520        530        540 
LEPSAPSKLH SVTGIDTKDK SLKTVSSGAK KSFELLSESD GALMEHPEVS QVRRKTVEFN 
       550        560        570        580    
LTDMPEIPEN HLKEPLEQSP TNIHTTLKDH MDPYWALENR DEAHS

Isoforms

- Isoform 3 of Bestrophin-1 - Isoform 4 of Bestrophin-1

Sequence View

        10         20         30         40         50         60 
MTITYTSQVA NARLGSFSRL LLCWRGSIYK LLYGEFLIFL LCYYIIRFIY RLALTEEQQL 
        70         80         90        100        110        120 
MFEKLTLYCD SYIQLIPISF VLGFYVTLVV TRWWNQYENL PWPDRLMSLV SGFVEGKDEQ 
       130        140        150        160        170        180 
GRLLRRTLIR YANLGNVLIL RSVSTAVYKR FPSAQHLVQA GFMTPAEHKQ LEKLSLPHNM 
       190        200        210        220        230        240 
FWVPWVWFAN LSMKAWLGGR IRDPILLQSL LNEMNTLRTQ CGHLYAYDWI SIPLVYTQVV 
       250        260        270        280        290        300 
TVAVYSFFLT CLVGRQFLNP AKAYPGHELD LVVPVFTFLQ FFFYVGWLKV AEQLINPFGE 
       310        320        330        340        350        360 
DDDDFETNWI VDRNLQVSLL AVDEMHQDLP RMEPDMYWNK PEPQPPYTAA SAQFRRASFM 
       370        380        390        400        410        420 
GSTFNISLNK EEMEFQPNQE DEEDAHAGII GRFLGLQSHD HHPPRANSRT KLLWPKRESL 
       430        440        450        460        470        480 
LHEGLPKNHK AAKQNVRGQE DNKAWKLKAV DAFKSAPLYQ RPGYYSAPQT PLSPTPMFFP 
       490        500        510        520        530        540 
LEPSAPSKLH SVTGIDTKDK SLKTVSSGAK KSFELLSESD GALMEHPEVS QVRRKTVEFN 
       550        560        570        580    
LTDMPEIPEN HLKEPLEQSP TNIHTTLKDH MDPYWALENR DEAHS         10         20         30         40         50         60 
MTITYTSQVA NARLGSFSRL LLCWRGSIYK LLYGEFLIFL LCYYIIRFIY RLALTEEQQL 
        70         80         90        100        110        120 
MFEKLTLYCD SYIQLIPISF VLGFYVTLVV TRWWNQYENL PWPDRLMSLV SGFVEGKDEQ 
       130        140        150        160        170        180 
GRLLRRTLIR YANLGNVLIL RSVSTAVYKR FPSAQHLVQA GFMTPAEHKQ LEKLSLPHNM 
       190        200        210        220        230        240 
FWVPWVWFAN LSMKAWLGGR IRDPILLQSL LNEMNTLRTQ CGHLYAYDWI SIPLVYTQVV 
       250        260        270        280        290        300 
TVAVYSFFLT CLVGRQFLNP AKAYPGHELD LVVPVFTFLQ FFFYVGWLKV AEQLINPFGE 
       310        320        330        340        350        360 
DDDDFETNWI VDRNLQVSLL AVDEMHQDLP RMEPDMYWNK PEPQPPYTAA SAQFRRASFM 
       370        380        390        400        410        420 
GSTFNISLNK EEMEFQPNQE DEEDAHAGII GRFLGLQSHD HHPPRANSRT KLLWPKRESL 
       430        440        450        460        470        480 
LHEGLPKNHK AAKQNVRGQE DNKAWKLKAV DAFKSAPLYQ RPGYYSAPQT PLSPTPMFFP 
       490        500        510        520        530        540 
LEPSAPSKLH SVTGIDTKDK SLKTVSSGAK KSFELLSESD GALMEHPEVS QVRRKTVEFN 
       550        560        570        580    
LTDMPEIPEN HLKEPLEQSP TNIHTTLKDH MDPYWALENR DEAHS



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

4 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...DEAHS 585 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...DEAHS 585 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt64003

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)