TopFIND 4.0

O81027: Hydroxymethylglutaryl-CoA lyase, mitochondrial

General Information

Protein names
- Hydroxymethylglutaryl-CoA lyase, mitochondrial
- HL
- HMG-CoA lyase
- 4.1.3.4
- 3-hydroxy-3-methylglutarate-CoA lyase
Gene names HMGCL
Organism Arabidopsis thaliana
Protease Family
Protease ID
Chromosome location
UniProt ID O81027

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MQWNGVRRAH SIWCKRLTNN THLHHPSIPV SHFFTMSSLE EPLSFDKLPS MSTMDRIQRF 
        70         80         90        100        110        120 
SSGACRPRDD VGMGHRWIEG RDCTTSNSCI DDDKSFAKES FPWRRHTRKL SEGEHMFRNI 
       130        140        150        160        170        180 
SFAGRTSTVS GTLRESKSFK EQKYSTFSNE NGTSHISNKI SKGIPKFVKI VEVGPRDGLQ 
       190        200        210        220        230        240 
NEKNIVPTSV KVELIQRLVS SGLPVVEATS FVSPKWVPQL ADAKDVMDAV NTLDGARLPV 
       250        260        270        280        290        300 
LTPNLKGFQA AVSAGAKEVA IFASASESFS LSNINCTIEE SLLRYRVVAT AAKEHSVPVR 
       310        320        330        340        350        360 
GYVSCVVGCP VEGPVLPSKV AYVVKELYDM GCFEISLGDT IGIGTPGSVV PMLEAVMAVV 
       370        380        390        400        410        420 
PADKLAVHFH DTYGQALANI LVSLQMGISI VDSSIAGLGG CPYAKGASGN VATEDVVYML 
       430        440        450        460    
NGLGVHTNVD LGKLIAAGDF ISKHLGRPNG SKAAVALNRR ITADASKI

Isoforms

- Isoform 2 of Hydroxymethylglutaryl-CoA lyase, mitochondrial

Sequence View

        10         20         30         40         50         60 
MQWNGVRRAH SIWCKRLTNN THLHHPSIPV SHFFTMSSLE EPLSFDKLPS MSTMDRIQRF 
        70         80         90        100        110        120 
SSGACRPRDD VGMGHRWIEG RDCTTSNSCI DDDKSFAKES FPWRRHTRKL SEGEHMFRNI 
       130        140        150        160        170        180 
SFAGRTSTVS GTLRESKSFK EQKYSTFSNE NGTSHISNKI SKGIPKFVKI VEVGPRDGLQ 
       190        200        210        220        230        240 
NEKNIVPTSV KVELIQRLVS SGLPVVEATS FVSPKWVPQL ADAKDVMDAV NTLDGARLPV 
       250        260        270        280        290        300 
LTPNLKGFQA AVSAGAKEVA IFASASESFS LSNINCTIEE SLLRYRVVAT AAKEHSVPVR 
       310        320        330        340        350        360 
GYVSCVVGCP VEGPVLPSKV AYVVKELYDM GCFEISLGDT IGIGTPGSVV PMLEAVMAVV 
       370        380        390        400        410        420 
PADKLAVHFH DTYGQALANI LVSLQMGISI VDSSIAGLGG CPYAKGASGN VATEDVVYML 
       430        440        450        460    
NGLGVHTNVD LGKLIAAGDF ISKHLGRPNG SKAAVALNRR ITADASKI



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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    O81027-1-unknown MQWNGV... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    O81027-36-unknown MSSLEE... 36 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt77094

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...DASKI 468 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...DASKI 468 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt72712

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)