O88351: Inhibitor of nuclear factor kappa-B kinase subunit beta

General Information

Protein names	- Inhibitor of nuclear factor kappa-B kinase subunit beta - I-kappa-B-kinase beta - IKK-B - IKK-beta - IkBKB - 2.7.11.10 - I-kappa-B kinase 2 - IKK2 - Nuclear factor NF-kappa-B inhibitor kinase beta - NFKBIKB
Gene names	Ikbkb
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	O88351

3 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSWSPSLPTQ TCGAWEMKER LGTGGFGNVI RWHNQATGEQ IAIKQCRQEL SPKNRNRWCL
        70         80         90        100        110        120
EIQIMRRLNH PNVVAARDVP EGMQNLAPND LPLLAMEYCQ GGDLRRYLNQ FENCCGLREG
       130        140        150        160        170        180
AVLTLLSDIA SALRYLHENR IIHRDLKPEN IVLQQGEKRL IHKIIDLGYA KELDQGSLCT
       190        200        210        220        230        240
SFVGTLQYLA PELLEQQKYT VTVDYWSFGT LAFECITGFR PFLPNWQPVQ WHSKVRQKSE
       250        260        270        280        290        300
VDIVVSEDLN GAVKFSSSLP FPNNLNSVLA ERLEKWLQLM LMWHPRQRGT DPQYGPNGCF
       310        320        330        340        350        360
RALDDILNLK LVHVLNMVTG TVHTYPVTED ESLQSLKTRI QENTGILETD QELLQKAGLV
       370        380        390        400        410        420
LLPDKPATQC ISDSKTNEGL TLDMDLVFLL DNSKINYETQ ITPRPPPESV SCILQEPKRN
       430        440        450        460        470        480
LSFFQLRKVW GQVWHSIQTL KEDCNRLQQG QRAAMMSLLR NNSCLSKMKN AMASTAQQLK
       490        500        510        520        530        540
AKLDFFKTSI QIDLEKYKEQ TEFGITSDKL LLAWREMEQA VEQCGRENDV KHLVERMMAL
       550        560        570        580        590        600
QTDIVDLQRS PMGRKQGGTL DDLEEQAREL YRKLREKPRD QRTEGDSQEM VRLLLQAIQS
       610        620        630        640        650        660
FEKKVRVIYT QLSKTVVCKQ KALELLPKVE EVVSLMNEDE RTVVRLQEKR QKELWNLLKI
       670        680        690        700        710        720
ACSKVRGPVS GSPDSMNVSR LSHPGQLMSQ PSSACDSLPE SDKKSEELVA EAHALCSRLE
       730        740        750
SALQDTVKEQ DRSFTTLDWS WLQMEDEERC SLEQACD

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O88351-1-unknown	MSWSPS...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O88351-413-unknown	ILQEPK...	413	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29579
O88351-709-unknown	VAEAHA...	709	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000120049

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RDLKPE	148	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000120916
...ESVSCI	412	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29579
...EQACD	757	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	412	VSCI.\|.ILQE	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> IKKB_MOUSE @412

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)