O88597: Beclin-1

General Information

Protein names	- Beclin-1 - Coiled-coil myosin-like BCL2-interacting protein - Beclin-1-C 35 kDa {ECO:0000303\|PubMed:21364619} - Beclin-1-C 37 kDa {ECO:0000303\|PubMed:21364619}
Gene names	Becn1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	O88597

2 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEGSKASSST MQVSFVCQRC SQPLKLDTSF KILDRVTIQE LTAPLLTTAQ AKPGETQEEE
        70         80         90        100        110        120
ANSGEEPFIE TRQDGVSRRF IPPARMMSTE SANSFTLIGE ASDGGTMENL SRRLKVTGDL
       130        140        150        160        170        180
FDIMSGQTDV DHPLCEECTD TLLDQLDTQL NVTENECQNY KRCLEILEQM NEDDSEQLQR
       190        200        210        220        230        240
ELKELALEEE RLIQELEDVE KNRKVVAENL EKVQAEAERL DQEEAQYQRE YSEFKRQQLE
       250        260        270        280        290        300
LDDELKSVEN QVRYAQIQLD KLKKTNVFNA TFHIWHSGQF GTINNFRLGR LPSVPVEWNE
       310        320        330        340        350        360
INAAWGQTVL LLHALANKMG LKFQRYRLVP YGNHSYLESL TDKSKELPLY CSGGLRFFWD
       370        380        390        400        410        420
NKFDHAMVAF LDCVQQFKEE VEKGETRFCL PYRMDVEKGK IEDTGGSGGS YSIKTQFNSE
       430        440
EQWTKALKFM LTNLKWGLAW VSSQFYNK

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

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Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

2 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O88597-1-Acetylation	MEGSKA...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O88597-98-unknown	IGEASD...	98		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29591

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NSFTLI	97	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29591
...TMENLS	110	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000122412
...YRLVPY	330	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000116580
...QFYNK	448	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	97	FTLI.\|.IGEA	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> BECN1_MOUSE @97

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)