TopFIND 4.0

O88623: Ubiquitin carboxyl-terminal hydrolase 2

General Information

Protein names
- Ubiquitin carboxyl-terminal hydrolase 2
- 3.4.19.12
- 41 kDa ubiquitin-specific protease
- Deubiquitinating enzyme 2
- Ubiquitin thioesterase 2
- Ubiquitin-specific-processing protease 2
Gene names Usp2
Organism Mus musculus
Protease Family
Protease ID C19.013
Chromosome location
UniProt ID O88623

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MSQLSSTLKR YTESSRYTDA PYAKPGYGTY TPSSYGANLA ASFLEKEKLG FKPVSPTSFL 
        70         80         90        100        110        120 
PRPRTYGPSS ILDCDRGRPL LRSDIIGSSK RSESQTRGNE RPSGSGLNGG SGFSYGVSSN 
       130        140        150        160        170        180 
SLSYLPMNAR DQGVTLSQKK SNSQSDLARD FSSLRTSDGY RTSEGFRIDP GNLGRSPMLA 
       190        200        210        220        230        240 
RTRKELCALQ GLYQAASRSE YLTDYLENYG RKGSAPQVLT QAPPPSRVPE VLSPTYRPSG 
       250        260        270        280        290        300 
RYTLWEKSKG QASGPSRSSS PGRDTMNSKS AQGLAGLRNL GNTCFMNSIL QCLSNTRELR 
       310        320        330        340        350        360 
DYCLQRLYMR DLGHTSSAHT ALMEEFAKLI QTIWTSSPND VVSPSEFKTQ IQRYAPRFMG 
       370        380        390        400        410        420 
YNQQDAQEFL RFLLDGLHNE VNRVAARPKA SPETLDHLPD EEKGRQMWRK YLEREDSRIG 
       430        440        450        460        470        480 
DLFVGQLKSS LTCTDCGYCS TVFDPFWDLS LPIAKRGYPE VTLMDCMRLF TKEDILDGDE 
       490        500        510        520        530        540 
KPTCCRCRAR KRCIKKFSVQ RFPKILVLHL KRFSESRIRT SKLTTFVNFP LRDLDLREFA 
       550        560        570        580        590        600 
SENTNHAVYN LYAVSNHSGT TMGGHYTAYC RSPVTGEWHT FNDSSVTPMS SSQVRTSDAY 
       610    
LLFYELASPP SRM

Isoforms

- Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 2 - Isoform 3 of Ubiquitin carboxyl-terminal hydrolase 2 - Isoform 4 of Ubiquitin carboxyl-terminal hydrolase 2

Sequence View

        10         20         30         40         50         60 
MSQLSSTLKR YTESSRYTDA PYAKPGYGTY TPSSYGANLA ASFLEKEKLG FKPVSPTSFL 
        70         80         90        100        110        120 
PRPRTYGPSS ILDCDRGRPL LRSDIIGSSK RSESQTRGNE RPSGSGLNGG SGFSYGVSSN 
       130        140        150        160        170        180 
SLSYLPMNAR DQGVTLSQKK SNSQSDLARD FSSLRTSDGY RTSEGFRIDP GNLGRSPMLA 
       190        200        210        220        230        240 
RTRKELCALQ GLYQAASRSE YLTDYLENYG RKGSAPQVLT QAPPPSRVPE VLSPTYRPSG 
       250        260        270        280        290        300 
RYTLWEKSKG QASGPSRSSS PGRDTMNSKS AQGLAGLRNL GNTCFMNSIL QCLSNTRELR 
       310        320        330        340        350        360 
DYCLQRLYMR DLGHTSSAHT ALMEEFAKLI QTIWTSSPND VVSPSEFKTQ IQRYAPRFMG 
       370        380        390        400        410        420 
YNQQDAQEFL RFLLDGLHNE VNRVAARPKA SPETLDHLPD EEKGRQMWRK YLEREDSRIG 
       430        440        450        460        470        480 
DLFVGQLKSS LTCTDCGYCS TVFDPFWDLS LPIAKRGYPE VTLMDCMRLF TKEDILDGDE 
       490        500        510        520        530        540 
KPTCCRCRAR KRCIKKFSVQ RFPKILVLHL KRFSESRIRT SKLTTFVNFP LRDLDLREFA 
       550        560        570        580        590        600 
SENTNHAVYN LYAVSNHSGT TMGGHYTAYC RSPVTGEWHT FNDSSVTPMS SSQVRTSDAY 
       610    
LLFYELASPP SRM         10         20         30         40         50         60 
MSQLSSTLKR YTESSRYTDA PYAKPGYGTY TPSSYGANLA ASFLEKEKLG FKPVSPTSFL 
        70         80         90        100        110        120 
PRPRTYGPSS ILDCDRGRPL LRSDIIGSSK RSESQTRGNE RPSGSGLNGG SGFSYGVSSN 
       130        140        150        160        170        180 
SLSYLPMNAR DQGVTLSQKK SNSQSDLARD FSSLRTSDGY RTSEGFRIDP GNLGRSPMLA 
       190        200        210        220        230        240 
RTRKELCALQ GLYQAASRSE YLTDYLENYG RKGSAPQVLT QAPPPSRVPE VLSPTYRPSG 
       250        260        270        280        290        300 
RYTLWEKSKG QASGPSRSSS PGRDTMNSKS AQGLAGLRNL GNTCFMNSIL QCLSNTRELR 
       310        320        330        340        350        360 
DYCLQRLYMR DLGHTSSAHT ALMEEFAKLI QTIWTSSPND VVSPSEFKTQ IQRYAPRFMG 
       370        380        390        400        410        420 
YNQQDAQEFL RFLLDGLHNE VNRVAARPKA SPETLDHLPD EEKGRQMWRK YLEREDSRIG 
       430        440        450        460        470        480 
DLFVGQLKSS LTCTDCGYCS TVFDPFWDLS LPIAKRGYPE VTLMDCMRLF TKEDILDGDE 
       490        500        510        520        530        540 
KPTCCRCRAR KRCIKKFSVQ RFPKILVLHL KRFSESRIRT SKLTTFVNFP LRDLDLREFA 
       550        560        570        580        590        600 
SENTNHAVYN LYAVSNHSGT TMGGHYTAYC RSPVTGEWHT FNDSSVTPMS SSQVRTSDAY 
       610    
LLFYELASPP SRM         10         20         30         40         50         60 
MSQLSSTLKR YTESSRYTDA PYAKPGYGTY TPSSYGANLA ASFLEKEKLG FKPVSPTSFL 
        70         80         90        100        110        120 
PRPRTYGPSS ILDCDRGRPL LRSDIIGSSK RSESQTRGNE RPSGSGLNGG SGFSYGVSSN 
       130        140        150        160        170        180 
SLSYLPMNAR DQGVTLSQKK SNSQSDLARD FSSLRTSDGY RTSEGFRIDP GNLGRSPMLA 
       190        200        210        220        230        240 
RTRKELCALQ GLYQAASRSE YLTDYLENYG RKGSAPQVLT QAPPPSRVPE VLSPTYRPSG 
       250        260        270        280        290        300 
RYTLWEKSKG QASGPSRSSS PGRDTMNSKS AQGLAGLRNL GNTCFMNSIL QCLSNTRELR 
       310        320        330        340        350        360 
DYCLQRLYMR DLGHTSSAHT ALMEEFAKLI QTIWTSSPND VVSPSEFKTQ IQRYAPRFMG 
       370        380        390        400        410        420 
YNQQDAQEFL RFLLDGLHNE VNRVAARPKA SPETLDHLPD EEKGRQMWRK YLEREDSRIG 
       430        440        450        460        470        480 
DLFVGQLKSS LTCTDCGYCS TVFDPFWDLS LPIAKRGYPE VTLMDCMRLF TKEDILDGDE 
       490        500        510        520        530        540 
KPTCCRCRAR KRCIKKFSVQ RFPKILVLHL KRFSESRIRT SKLTTFVNFP LRDLDLREFA 
       550        560        570        580        590        600 
SENTNHAVYN LYAVSNHSGT TMGGHYTAYC RSPVTGEWHT FNDSSVTPMS SSQVRTSDAY 
       610    
LLFYELASPP SRM



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Evidence Codes:


Methodology:


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Biological System:


Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    O88623-1-unknown MSQLSS... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    O88623-1-unknown MSQLSS... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt93677

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)